The DOI matches its Crossref record; 29 of the 29 references it cites were found in a registry or an index.
N6-methyladenosine METTL3 promotes cervical cancer tumorigenesis and Warburg effect through YTHDF1/HK2 modification
Open accessAbstract
N6-methyladenosine (m 6 A) serves as the most common and conserved internal transcriptional modification. However, the roles of m 6 A on cervical cancer (CC) tumorigenesis are still unclear. Here, results indicated that METTL3 was significantly upregulated in CC tissue and cells, which was closely correlated with the lymph node metastasis and poor prognosis of CC patients. MeRIP-Seq analysis revealed the m 6 A profiles in CC cells. Functionally, METTL3 promoted the proliferation and Warburg effect (aerobic glycolysis) of CC cells. Mechanistically, METTL3 targeted the 3’-Untranslated Region (3’-UTR) of hexokinase 2 (HK2) mRNA. Moreover, METTL3 recruited YTHDF1, a m 6 A reader, to enhance HK2 stability. These findings demonstrated that METTL3 enhanced the HK2 stability through YTHDF1-mediated m 6 A modification, thereby promoting the Warburg effect of CC, which might promote a novel insight for the CC treatment.
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1 retracted
Lin, X., Chai, G., Wu, Y., Li, J., Chen, F., Liu, J., Luo, G., Tauler, J., Du, J., Lin, S., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-09865-9 · Cited by 510
Self-citationRetractedUnderstanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation
Vander Heiden, M. G., Cantley, L. C., & Thompson, C. B. (2009) · Science · doi:10.1126/science.1160809 · Cited by 16,197
The role of m6A RNA methylation in human cancer
Chen, X.-Y., Zhang, J., & Zhu, J.-S. (2019) · Molecular Cancer · doi:10.1186/s12943-019-1033-z · Cited by 884
Wang, Q., Chen, C., Ding, Q., Zhao, Y., Wang, Z., Chen, J., Jiang, Z., Zhang, Y., Xu, G., Zhang, J., et al. (2020) · Gut · doi:10.1136/gutjnl-2019-319639 · Cited by 862
Self-citationMETTL3 facilitates tumor progression via an m6A-IGF2BP2-dependent mechanism in colorectal carcinoma
Li, T., Hu, P.-S., Zuo, Z., Lin, J.-F., Li, X., Wu, Q.-N., Chen, Z.-H., Zeng, Z.-L., Wang, F., Zheng, J., et al. (2019) · Molecular Cancer · doi:10.1186/s12943-019-1038-7 · Cited by 799
The Critical Role of RNA m6A Methylation in Cancer
Lan, Q., Liu, P. Y., Haase, J., Bell, J. L., Hüttelmaier, S., & Liu, T. (2019) · Cancer Research · doi:10.1158/0008-5472.can-18-2965 · Cited by 720
RNA N6-methyladenosine demethylase FTO promotes breast tumor progression through inhibiting BNIP3
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Self-citationSocial determinants of breast cancer risk, stage, and survival
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Cited by
The role of m6A RNA methylation in cancer metabolism
An, Y., & Duan, H. (2022) · Molecular Cancer · doi:10.1186/s12943-022-01500-4 · Cited by 871
Reading the m6A-encoded epitranscriptomic information in development and diseases
Chen, Y., Zhou, Z., Chen, Y., & Chen, D. (2024) · Cell & Bioscience · doi:10.1186/s13578-024-01293-7 · Cited by 24
Metadata
- Authors
- Wang, Q., Guo, X., Li, L., Gao, Z., Su, X., Ji, M., & Liu, J.
- Venue
- Cell Death & Disease
- Published
- 2020-10-24
- Volume
- 11
- Issue
- 10
- Pages
- 911-911
- ISSN
- 2041-4889 (ISSN-L)
- OpenAlex
- W3093757759
- Cited by
- 308
- References
- 29
- FWCI
- 11.41
- Type
- journal article
- Language
- en
- Open access
- gold
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- Wang, Q., Guo, X., Li, L., Gao, Z., Su, X., Ji, M., & Liu, J. (2020). N6-methyladenosine METTL3 promotes cervical cancer tumorigenesis and Warburg effect through YTHDF1/HK2 modification. Cell Death & Disease. https://doi.org/10.1038/s41419-020-03071-y
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