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The role of m6A RNA methylation in human cancer

Chen, Xiao-Yu, Zhang, Jing, Zhu, Jin-Shui·2019·Molecular Cancer
DOI 10.1186/s12943-019-1033-zPMC PMC6540575
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Fig. 1 Molecular composition of m6A RNA methylation. M6A methylation is a dynamic and reversible process coordinated by a series of methyltransferases (METTL3/14, WTAP, RBM15/15B, and KIAA1429, termed as “m6A writers”), demethylases (FTO and ALKBH5, “m6A erasers”) and identifiers (YTHDF1/2/3, YTHDC1, HNRNPA2B1, HNRNPC, eIF3, FMR1, and LRPPRC, “m6A. ‘Readers”)
Fig. 1 Molecular composition of m6A RNA methylation. M6A methylation is a dynamic and reversible process coordinated by a series of methyltransferases (METTL3/14, WTAP, RBM15/15B, and KIAA1429, termed as “m6A writers”), demethylases (FTO and ALKBH5, “m6A erasers”) and identifiers (YTHDF1/2/3, YTHDC1, HNRNPA2B1, HNRNPC, eIF3, FMR1, and LRPPRC, “m6A. ‘Readers”)CC BY · PubMed Central
Fig. 2 Regulatory Functions of m6A modification in RNA splicing, processing, translation and degradation. M6A RNA modification is involved in regulating the life cycle of RNA including RNA splicing (regulated by WTAP, FTO, ALKBH5 and YTHDC1), RNA processing (regulated by METTL3/14 and ALKBH5), RNA translation (regulated by METTL3, YTHDF1/3, eIF3 and FMR1) and RNA degradation (regulated by YTHDF2)
Fig. 2 Regulatory Functions of m6A modification in RNA splicing, processing, translation and degradation. M6A RNA modification is involved in regulating the life cycle of RNA including RNA splicing (regulated by WTAP, FTO, ALKBH5 and YTHDC1), RNA processing (regulated by METTL3/14 and ALKBH5), RNA translation (regulated by METTL3, YTHDF1/3, eIF3 and FMR1) and RNA degradation (regulated by YTHDF2)CC BY · PubMed Central
Fig. 3 The role of m6A RNA modification in human cancer. M6A RNA modification is associated with the tumorigenesis of multiple malignancies including AML, GBM, HCC, CRC, NPC, breast cancer, lung cancer, pancreatic cancer, bladder cancer and endometrial cancer
Fig. 3 The role of m6A RNA modification in human cancer. M6A RNA modification is associated with the tumorigenesis of multiple malignancies including AML, GBM, HCC, CRC, NPC, breast cancer, lung cancer, pancreatic cancer, bladder cancer and endometrial cancerCC BY · PubMed Central

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Metadata

Authors
Chen, X.-Y., Zhang, J., & Zhu, J.-S.
ORCID
Zhu, Jin-Shui
Venue
Molecular Cancer
Publisher
Springer Science and Business Media LLC
Published
2019-05-29
Volume
18
Issue
1
ISSN
1476-4598
DOI
10.1186/s12943-019-1033-z
PMC
PMC6540575
Cited by
884
References
11
Language
en
Licence
Funders
  • National Natural Science Foundation of China (81873143, 81573747)
  • Science and Technology Commission of Shanghai Municipality (17411966500)

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