The DOI matches its Crossref record; 83 of the 83 references it cites were found in a registry or an index.
The therapeutic potential of mesenchymal stem cells for cardiovascular diseases
Open accessAbstract
Mesenchymal stem cells (MSCs) are derived from a wide range of sources and easily isolated and cultured. MSCs have the capacity for in vitro amplification and self-renewal, low immunogenicity and immunomodulatory properties, and under certain conditions, MSCs can be differentiated into a variety of cells. In the cardiovascular system, MSCs can protect the myocardium by reducing the level of inflammation, promoting the differentiation of myocardial cells around infarct areas and angiogenesis, increasing apoptosis resistance, and inhibiting fibrosis, which are ideal qualities for cardiovascular repair. Preclinical studies have shown that MSCs can be transplanted and improve cardiac repair, but challenges, such as their low rate of migration to the ischemic myocardium, low tissue retention, and low survival rate after transplantation, remain. This article reviews the potential and methods of MSC transplantation in the treatment of cardiovascular diseases (CVDs) and the challenges of the clinical use of MSCs.
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Cites
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Cited by
Yang, Y., Johnson, J., Troupes, C. D., Feldsott, E. A., Kraus, L., Megill, E., Bian, Z., Asangwe, N., Kino, T., Eaton, D. M., et al. (2023) · Redox Biology · doi:10.1016/j.redox.2023.102909 · Cited by 20
Metadata
- Authors
- Guo, Y., Yu, Y., Hu, S., Chen, Y., & Shen, Z.
- Venue
- Cell Death & Disease
- Published
- 2020-05-11
- Volume
- 11
- Issue
- 5
- Pages
- 349-349
- ISSN
- 2041-4889 (ISSN-L)
- OpenAlex
- W3022386151
- Cited by
- 298
- References
- 83
- FWCI
- 16.50
- Type
- journal article
- Language
- en
- Open access
- gold
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- Guo, Y., Yu, Y., Hu, S., Chen, Y., & Shen, Z. (2020). The therapeutic potential of mesenchymal stem cells for cardiovascular diseases. Cell Death & Disease. https://doi.org/10.1038/s41419-020-2542-9
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