Hedgehog signalling is involved in acquired resistance to KRASG12C inhibitors in lung cancer cells

Lee, Chaeyoung; Yi, Jawoon; Park, Jihwan; Ahn, Byungyong; Won, Young-Wook; Jeon, JiHeung; Lee, Byung Ju; Cho, Wha Ja; Park, Jeong Woo

doi:10.1038/s41419-024-06436-9

Hedgehog signalling is involved in acquired resistance to KRASG12C inhibitors in lung cancer cells

Although KRAS G12C inhibitors have shown promising activity in lung adenocarcinomas harbouring KRAS G12C , acquired resistance to these therapies eventually occurs in most patients. Re-expression of KRAS is thought to be one of the main causes of acquired resistance. However, the mechanism throug…