Cited by 1,875Receptor Mechanisms and SignalingProtein Kinase Regulation and GTPase SignalingProtein Structure and Dynamics

The Guanine Nucleotide-Binding Switch in Three Dimensions

Vetter, Ingrid R., Wittinghofer, Alfred·2001·Science

Abstract

Guanine nucleotide–binding proteins regulate a variety of processes, including sensual perception, protein synthesis, various transport processes, and cell growth and differentiation. They act as molecular switches and timers that cycle between inactive guanosine diphosphate (GDP)–bound and active guanosine triphosphate (GTP)–bound states. Recent structural studies show that the switch apparatus itself is a conserved fundamental module but that its regulators and effectors are quite diverse in their structures and modes of interaction. Here we will try to define some underlying principles.

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Crossref · 10.1126/science.1062023

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Authors
Vetter, I. R., & Wittinghofer, A.
Affiliations
Max Planck Institute of Molecular Physiology (DE)
Venue
Science
Published
2001-11-09
Volume
294
Issue
5545
Pages
1299-1304
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
OpenAlex
W2156571424
Cited by
1,875
References
69
Citations by year
2026: 58 · 2025: 63 · 2024: 102 · 2023: 69 · 2022: 83 · 2021: 78 · 2020: 95 · 2019: 80 · 2018: 72 · 2017: 78 · 2016: 76 · 2015: 82 · 2014: 71 · 2013: 89 · 2012: 87
FWCI
3.10
Type
journal article
Language
en
Open access
closed
Locations
  • Science (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Receptor Mechanisms and Signaling
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Structure and Dynamics
Keywords
G proteins, molecular switches, protein structure, G protein structure, signal transduction, protein structure-function relationship
MeSH terms
Allosteric Regulation, Binding Sites, Guanosine Diphosphate, Guanosine Triphosphate, Hydrolysis, Models, Molecular, Protein Conformation, Protein Structure, Tertiary, GTP-Binding Proteins, GTP Phosphohydrolases, Guanine Nucleotide Exchange Factors, GTPase-Activating Proteins, Guanine Nucleotide Dissociation Inhibitors

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