A novel therapeutic anticancer property of raw garlic extract via injection but not ingestion
Open accessAbstract
Prior studies suggest a possibility that the anticancer property of garlic is more effective only when exposed directly to cancer cells than absorbed first by the normal epithelial cells of the gastrointestinal tract wall. We tested this possibility in two mouse models of highly aggressive malignancies that cannot yet be cured by conventional therapies: sarcoma 180- and EL4-induced lethal ascites. Daily oral gavages of raw garlic extract (RGE; equivalent to 100 mg wet weight) for 21 days failed to offer any meaningful effect in the mice with malignancies. However, the daily injection of the same amounts of the same materials for 21 days completely cured all the mice of cancer. This novel anticancer activity of RGE was present entirely in the size fraction of the molecules smaller than 3000 Dalton rather than the larger molecules and was completely partitioned into the organic phase rather than into the aqueous phase. One half of the anticancer activity was inactivated by heating at 100 °C for 10 min, suggesting that multiple components were concertedly involved. In a direct comparison, the RGE was significantly more effective in killing the cultured cancer cells in vitro than the extracts from other 21 raw vegetables and fruits. In cell culture, RGE killed a wide variety of different cancer cells regardless of species of origin and cell types. Cancer cells generally are well known to be defective in many common metabolic pathways present in their normal cell counterpart for processing normal nutrients. The metabolism of these otherwise normal nutrients could be stalled in the cancer cells and become cytotoxic. The most-effective way of treating cancer by RGE may be the direct injection instead of eating the cooked garlic.
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Raw garlic extract is the most effective and highly specific anticancer drug when compared with 33 raw vegetable extracts against different cancer cells without affecting non-cancerous cells.
“Raw garlic extract was found to be the most effective and highly specific anticancer drug when compared with 33 raw vegetable extracts against different cancer cells without affecting the non-cancerous cells [78].”
From Chemical Constituents and Pharmacological Activities of Garlic (Allium sativum L.): A Review (2020) · cites this paper as [78]
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- Authors
- Li, Z., Le, W., & Cui, Z.
- Affiliations
- Wake Forest University Health Sciences (US)
- Tongji University (CN)
- Corresponding author
- Cui, Zheng
- Venue
- Cell Death Discovery
- Published
- 2018-11-21
- Volume
- 4
- Issue
- 1
- Pages
- 108-108
- ISSN
- 2058-7716 (ISSN-L)
- PMC
- PMC6249268
- OpenAlex
- W2901975034
- Cited by
- 55
- References
- 35
- Citations by year
- 2026: 3 · 2025: 8 · 2024: 6 · 2023: 7 · 2022: 12 · 2021: 10 · 2020: 5 · 2019: 4
- FWCI
- 4.20
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Cell Death Discovery (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Funders
- Wake Forest University
- China Scholarship Council
- Topics
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Garlic and Onion Studies
- Physical Sciences › Chemistry › Organic Chemistry › Chemical synthesis and alkaloids
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics, phytochemicals, and oxidative stress
- Keywords
- anticancer activity, intravenous injection, oral administration, sarcoma 180, heat-sensitive compounds, tumor cell killing, dietary phytochemicals, cancer metabolism
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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