The DOI matches its Crossref record; 68 of the 68 references it cites were found in a registry or an index.
The caspase-3/GSDME signal pathway as a switch between apoptosis and pyroptosis in cancer
Open accessAbstract
Apoptosis has long been recognized as a mechanism that kills the cancer cells by cytotoxic drugs. In recent years, studies have proved that pyroptosis can also shrink tumors and inhibit cells proliferation. Both apoptosis and pyroptosis are caspase-dependent programmed cell death pathways. Cysteinyl aspartate specific proteinase-3 (Caspase-3) is a common key protein in the apoptosis and pyroptosis pathways, and when activated, the expression level of tumor suppressor gene Gasdermin E (GSDME) determines the mechanism of tumor cell death. When GSDME is highly expressed, the active caspase-3 cuts it and releases the N-terminal domain to punch holes in the cell membrane, resulting in cell swelling, rupture, and death. When the expression of GSDME is low, it will lead to the classical mechanism of tumor cell death, which is apoptosis. More interestingly, researchers have found that GSDME can also be located upstream of caspase-3, connecting extrinsic, and intrinsic apoptotic pathways. Then, promoting caspase-3 activation, and forming a self-amplifying feed-forward loop. GSDME-mediated pyroptosis is correlated with the side effects of chemotherapy and anti-tumor immunity. This article mainly reviews the caspase-3/GSDME signal pathway as a switch between apoptosis and pyroptosis in cancer, to provide new strategies and targets for cancer treatment.
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Cites
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Chemotherapy drugs induce pyroptosis through caspase-3 cleavage of a gasdermin
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Caspase Functions in Cell Death and Disease
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Gasdermin E suppresses tumour growth by activating anti-tumour immunity
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Granzyme A from cytotoxic lymphocytes cleaves GSDMB to trigger pyroptosis in target cells
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Cited by
A novel defined pyroptosis-related gene signature for predicting the prognosis of ovarian cancer
Ye, Y., Dai, Q., & Qi, H. (2021) · Cell Death Discovery · doi:10.1038/s41420-021-00451-x · Cited by 451
Programmed Cell Death Tunes Tumor Immunity
Liu, J., Hong, M., Li, Y., Chen, D., Wu, Y., & Hu, Y. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.847345 · Cited by 316
Self-citationCai, J., Yi, M., Tan, Y., Li, X., Li, G., Zeng, Z., Xiong, W., & Xiang, B. (2021) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-021-01995-7 · Cited by 215
Apoptin induces pyroptosis of colorectal cancer cells via the GSDME-dependent pathway
Liu, Z., Li, Y., Zhu, Y., Li, N., Li, W., Shang, C., Song, G., Li, S., Cong, J., Li, T., et al. (2022) · International Journal of Biological Sciences · doi:10.7150/ijbs.64350 · Cited by 93
Self-citationTian, D., Xing, Y., Gao, W., Zhang, H., Song, Y., Tian, Y., & Dai, Z. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.801422 · Cited by 52
Metadata
- Authors
- Jiang, M., Qi, L., Li, L., & Li, Y.
- Venue
- Cell Death Discovery
- Published
- 2020-10-28
- Volume
- 6
- Issue
- 1
- Pages
- 112-112
- ISSN
- 2058-7716 (ISSN-L)
- OpenAlex
- W3095202855
- Cited by
- 686
- References
- 68
- FWCI
- 19.78
- Type
- journal article
- Language
- en
- Open access
- gold
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