The DOI matches its Crossref record; 234 of the 234 references it cites were found in a registry or an index.
Programmed Cell Death Tunes Tumor Immunity
Open accessAbstract
The demise of cells in various ways enables the body to clear unwanted cells. Studies over the years revealed distinctive molecular mechanisms and functional consequences of several key cell death pathways. Currently, the most intensively investigated programmed cell death (PCD) includes apoptosis, necroptosis, pyroptosis, ferroptosis, PANoptosis, and autophagy, which has been discovered to play crucial roles in modulating the immunosuppressive tumor microenvironment (TME) and determining clinical outcomes of the cancer therapeutic approaches. PCD can play dual roles, either pro-tumor or anti-tumor, partly depending on the intracellular contents released during the process. PCD also regulates the enrichment of effector or regulatory immune cells, thus participating in fine-tuning the anti-tumor immunity in the TME. In this review, we focused primarily on apoptosis, necroptosis, pyroptosis, ferroptosis, PANoptosis, and autophagy, discussed the released molecular messengers participating in regulating their intricate crosstalk with the immune response in the TME, and explored the immunological consequence of PCD and its implications in future cancer therapy developments.
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Cites
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Metadata
- Authors
- Liu, J., Hong, M., Li, Y., Chen, D., Wu, Y., & Hu, Y.
- Venue
- Frontiers in Immunology
- Publisher
- Frontiers Media SA
- Published
- 2022-03-30
- Volume
- 13
- Pages
- 847345-847345
- ISSN
- 1664-3224 (ISSN-L)
- OpenAlex
- W4220936076
- Cited by
- 316
- References
- 234
- FWCI
- 20.30
- Type
- journal article
- Language
- en
- Open access
- gold
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- Liu, J., Hong, M., Li, Y., Chen, D., Wu, Y., & Hu, Y. (2022). Programmed Cell Death Tunes Tumor Immunity. Frontiers in Immunology. https://doi.org/10.3389/fimmu.2022.847345
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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