Chemokine-derived oncolytic peptide induces immunogenic cancer cell death and significantly suppresses tumor growth
Open accessPublished version of a preprint
Abstract
Chemokinostatin-1 (CKS1) is a 24-mer peptide originally discovered as an anti-angiogenic peptide derived from the CXCL1 chemokine. Here, we demonstrate that CKS1 acts not only as an anti-angiogenic peptide but also as an oncolytic peptide due to its structural and physical properties. CKS1 induced both necrotic and apoptotic cell death specifically in cancer cells while showing minimal toxicity in non-cancerous cells. Mechanistically, CKS1 disrupted the cell membrane of cancer cells quickly after treatment and activated the apoptotic pathway at later time points. Furthermore, immunogenic molecules were released from CKS1-treated cells, indicating that CKS1 induces immunogenic cell death. CKS1 effectively suppressed tumor growth in vivo. Collectively, these data demonstrate that CKS1 functions as an oncolytic peptide and has a therapeutic potential to treat cancer.
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Highly accurate protein structure prediction with AlphaFold
Jumper, J., Evans, R., Pritzel, A., Green, T., Figurnov, M., Ronneberger, O., Tunyasuvunakool, K., Bates, R., Žídek, A., Potapenko, A., et al. (2021) · Nature · doi:10.1038/s41586-021-03819-2 · Cited by 43,764 · see citing works
Molecular mechanisms of ATP secretion during immunogenic cell death
Martins, I., Wang, Y., Michaud, M., Ma, Y., Sukkurwala, A. Q., Shen, S., Kepp, O., Métivier, D., Galluzzi, L., Perfettini, J.-L., et al. (2014) · Cell Death & Differentiation · doi:10.1038/cdd.2013.75 · Cited by 563 · see citing works
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- Authors
- Furukawa, N., Yang, W., Chao, A. R., Patil, A., Mirando, A. C., Pandey, N. B., & Popel, A. S.
- Affiliations
- Johns Hopkins University (US)
- Corresponding author
- Furukawa, Natsuki
- Venue
- Cell Death Discovery
- Published
- 2024-04-02
- Volume
- 10
- Issue
- 1
- Pages
- 161-161
- ISSN
- 2058-7716 (ISSN-L)
- PMC
- PMC10987543
- OpenAlex
- W4393396983
- Cited by
- 10
- References
- 2
- Citations by year
- 2026: 4 · 2025: 4 · 2024: 2
- FWCI
- 1.36
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Cell Death Discovery (publishedVersion, cc-by)
- Research Square (acceptedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- PubMed Central (submittedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- U.S. Department of Health & Human Services | NIH | National Cancer Institute (R01CA138264, P30 CA006973)
- U.S. Department of Health & Human Services | National Institutes of Health (S10OD016374)
- Takenaka Scholarship Foundation
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
- Life Sciences › Immunology and Microbiology › Microbiology › Antimicrobial Peptides and Activities
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Chemical Synthesis and Analysis
- Keywords
- oncolytic peptide, immunogenic cell death, anti-angiogenic peptides, apoptosis, necrosis, cell membrane damage, tumor growth inhibition, cancer therapy
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