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Neutralization of Omicron XBB.1 by booster vaccination with BA.4/5 monovalent mRNA vaccine

Zhao, Hui, Zhang, Na-Na, Hannawi, Suad, Zhu, Ai-Ru, Xiong, Xiao-Chuan, Huang, Yi-Jiao, Yu, Dan-Dan, Chen, Can-Jie, Dai, Jun, Abuquta, Alaa, Ying, Bo, Zhao, Jin-Cun, Qin, Cheng-Feng·2024·Cell Discovery

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Crossref · 10.1038/s41421-023-00609-0

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Fig. 1 Neutralizing responses with the monovalent BA.4/5 mRNA vaccine booster. a Mutations in amino acids of the RBD of S protein edcoded by the monovalent BA.4/5 mRNA vaccine (ABO1020), ARCoV, XBB and XBB.1.9. The amino acid differences in variant sequences from those in BA.4/5 are highlighted. b 50% authentic virus neutralization titers against Omicron subvariants BA.5 and XBB after two-dose booster of ABO1020. The neutralizing antibody titers were assessed on day 0 before booster and day 28 after each booster (1st and 2nd boost), respectively. c 50% authentic virus neutralization titers against Omicron subvariants BA.5 and XBB.1.9 after a single booster of ABO1020. The neutralizing antibody titers were assessed on day 0 before booster and day 14 after booster, respectively. d 50% pseudovirus neutralization titers against prototype strain, Delta and Omicron subvariants BA.1, BA.2.12.1, BA.2.75.2, BA.4/5, BF.7, XBB.1.5, XBB.1.16 and BQ.1.1 after a single booster of ABO1020. Each dot represents a participant. Average antibody levels are represented by GMT values. The GMFI values in neutralizing titers before and after booster are shown. Statistical significance was determined using the unpaired t-test (b, c) or multiple unpaired t-tests (d) between before and after booster. The dashed horizontal line represents the lower limit of detection.
Fig. 1 Neutralizing responses with the monovalent BA.4/5 mRNA vaccine booster. a Mutations in amino acids of the RBD of S protein edcoded by the monovalent BA.4/5 mRNA vaccine (ABO1020), ARCoV, XBB and XBB.1.9. The amino acid differences in variant sequences from those in BA.4/5 are highlighted. b 50% authentic virus neutralization titers against Omicron subvariants BA.5 and XBB after two-dose booster of ABO1020. The neutralizing antibody titers were assessed on day 0 before booster and day 28 after each booster (1st and 2nd boost), respectively. c 50% authentic virus neutralization titers against Omicron subvariants BA.5 and XBB.1.9 after a single booster of ABO1020. The neutralizing antibody titers were assessed on day 0 before booster and day 14 after booster, respectively. d 50% pseudovirus neutralization titers against prototype strain, Delta and Omicron subvariants BA.1, BA.2.12.1, BA.2.75.2, BA.4/5, BF.7, XBB.1.5, XBB.1.16 and BQ.1.1 after a single booster of ABO1020. Each dot represents a participant. Average antibody levels are represented by GMT values. The GMFI values in neutralizing titers before and after booster are shown. Statistical significance was determined using the unpaired t-test (b, c) or multiple unpaired t-tests (d) between before and after booster. The dashed horizontal line represents the lower limit of detection.CC BY · PubMed Central

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Research works printed but not linked: 9

  1. Callaway, E. Nature 611, 213–214 (2022). · DOI
  2. Carabelli, A. M. et al. Nat. Rev. Microbiol. 21, 162–177 (2023).
  3. Cao, Y. et al. Nature 614, 521–529 (2023).
  4. Wang, Q. et al. Cell 186, 279–286 (2023). · DOI · Paper page
  5. Röltgen, K. et al. Cell 185, 1025–1040 (2022). · DOI
  6. Hannawi, S. et al. Clin. Transl. Med. 13, e1387 (2023). · DOI
  7. Wang, Z. et al. Emerg. Microbes Infect. 11, 829–840 (2022). · DOI
  8. Zou, J. et al. N. Engl. J. Med. 388, 854–857 (2023). · DOI
  9. Miller, J. et al. N. Engl. J. Med. 388, 662–664 (2023). · DOI

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Metadata

Authors
Zhao, H., Zhang, N.-N., Hannawi, S., Zhu, A.-R., Xiong, X.-C., Huang, Y.-J., Yu, D.-D., Chen, C.-J., Dai, J., Abuquta, A., Ying, B., Zhao, J.-C., & Qin, C.-F.
Venue
Cell Discovery
Published
2024-01-09
Volume
10
Issue
1
ISSN
2056-5968
Cited by
5
References
1
Language
en
Funders
National Natural Science Foundation of China (81925025)

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