The DOI matches its Crossref record; 159 of the 159 references it cites were found in a registry or an index.
Epigenetic regulation of macrophages: from homeostasis maintenance to host defense
Open accessAbstract
Macrophages are crucial members of the innate immune response and important regulators. The differentiation and activation of macrophages require the timely regulation of gene expression, which depends on the interaction of a variety of factors, including transcription factors and epigenetic modifications. Epigenetic changes also give macrophages the ability to switch rapidly between cellular programs, indicating the ability of epigenetic mechanisms to affect phenotype plasticity. In this review, we focus on key epigenetic events associated with macrophage fate, highlighting events related to the maintenance of tissue homeostasis, responses to different stimuli and the formation of innate immune memory. Further understanding of the epigenetic regulation of macrophages will be helpful for maintaining tissue integrity, preventing chronic inflammatory diseases and developing therapies to enhance host defense.
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1 retracted
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“In addition, macrophages are major producers of cytokines, which are implicated in the pathogenesis of inflammatory disease, and are strategically placed to orchestrate both innate immune responses and adaptive immune responses.(4,5) Macrophages display high heterogeneity, not only in their inherent terminal different…”
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Cited by
Epigenetic modulation of antitumor immunity for improved cancer immunotherapy
Dai, E., Zhu, Z., Wahed, S., Qu, Z., Storkus, W. J., & Guo, Z. S. (2021) · Molecular Cancer · doi:10.1186/s12943-021-01464-x · Cited by 328
Functional inference of gene regulation using single-cell multi-omics
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The Potential Role of Cytokines and Growth Factors in the Pathogenesis of Alzheimer’s Disease
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Ricci, A., Gallorini, M., Feghali, N., Sampò, S., Cataldi, A., & Zara, S. (2023) · Molecules · doi:10.3390/molecules28031222 · Cited by 30
Miyazaki, H., Wannakul, T., Yang, S., Yang, D., Karasawa, A., Shishido, A., Cao, R., Yamamoto, Y., Kagawa, Y., Kobayashi, S., et al. (2025) · Journal of Immunology Research · doi:10.1155/jimr/6987981 · Cited by 9
“Recent studies have highlighted epigenetic regulation as a potential mechanism underlying macrophage polarization [36].”
Metadata
- Authors
- Chen, S., Yang, J., Wei, Y., & Wei, X.
- Venue
- Cellular & Molecular Immunology
- Published
- 2019-10-29
- Volume
- 17
- Issue
- 1
- Pages
- 36-49
- ISSN
- 1672-7681 (ISSN-L)
- 2042-0226
- OpenAlex
- W2982346128
- Cited by
- 316
- References
- 159
- FWCI
- 9.24
- Type
- journal article
- Language
- en
- Open access
- hybrid
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