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Cited by 169T-cell and B-cell ImmunologyRNA and protein synthesis mechanismsMuscle metabolism and nutrition

Protein synthesis, degradation, and energy metabolism in T cell immunity

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Marchingo, Julia M., Cantrell, Doreen A.·2022·Cellular & Molecular Immunology
DOI 10.1038/s41423-021-00792-8PMC PMC8891282
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Abstract

T cell activation, proliferation, and differentiation into effector and memory states involve massive remodeling of T cell size and molecular content and create a massive increase in demand for energy and amino acids. Protein synthesis is an energy- and resource-demanding process; as such, changes in T cell energy production are intrinsically linked to proteome remodeling. In this review, we discuss how protein synthesis and degradation change over the course of a T cell immune response and the crosstalk between these processes and T cell energy metabolism. We highlight how the use of high-resolution mass spectrometry to analyze T cell proteomes can improve our understanding of how these processes are regulated.

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  • Levels of the translation repressor PDCD4 are significantly reduced in Tex cells both in vitro and in vivo.

    “Fourth, levels of the translation repressor PDCD4 (refs. 36,37) were significantly reduced in Tex cells both in vitro and in vivo”

    From Proteotoxic stress response drives T cell exhaustion and immune evasion (2025) · cites this paper as [37]

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Cited by

Sorted by citations

Authors
Marchingo, J. M., & Cantrell, D. A.
Affiliations
University of Dundee (GB)
Corresponding author
Cantrell, Doreen A.
ORCID
Venue
Cellular & Molecular Immunology
Publisher
Springer Science and Business Media LLC
Published
2022-01-04
Volume
19
Issue
3
Pages
303-315
ISSN
  • 1672-7681 (ISSN-L)
  • 2042-0226
DOI
10.1038/s41423-021-00792-8
PMC
PMC8891282
OpenAlex
W4205154917
Cited by
169
References
12
Citations by year
2026: 32 · 2025: 55 · 2024: 47 · 2023: 28 · 2022: 7
FWCI
3.59
Type
journal article
Language
en
Open access
Licence
Locations
  • Cellular and Molecular Immunology (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • Discovery Research Portal (University of Dundee) (submittedVersion, cc-by)
Funders
  • Wellcome Trust (205023/Z/16/Z)
  • Department of Health | National Health and Medical Research Council (APP1120748)
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
Keywords
T cell immunity, protein synthesis, protein degradation, T cell energy metabolism, proteome remodeling, T cell activation, T cell proliferation, amino acid metabolism
MeSH terms
Cell Differentiation, Energy Metabolism, Lymphocyte Activation, T-Lymphocytes, Proteome

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