PDK1 regulation of mTOR and hypoxia-inducible factor 1 integrate metabolism and migration of CD8+ T cells

Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources

Huang, D. W., Sherman, B. T., & Lempicki, R. A. (2009) · Nature Protocols · doi:10.1038/nprot.2008.211 · Cited by 35,890 · see citing works

MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification

Cox, J., & Mann, M. (2008) · Nature Biotechnology · doi:10.1038/nbt.1511 · Cited by 14,855 · see citing works

Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists

Huang, D. W., Sherman, B. T., & Lempicki, R. A. (2009) · Nucleic Acids Research · doi:10.1093/nar/gkn923 · Cited by 14,108 · see citing works

Prolonged Rapamycin Treatment Inhibits mTORC2 Assembly and Akt/PKB

Sarbassov, D. D., Ali, S. M., Sengupta, S., Sheen, J.-H., Hsu, P. P., Bagley, A. F., Markhard, A. L., & Sabatini, D. M. (2006) · Molecular Cell · doi:10.1016/j.molcel.2006.03.029 · Cited by 2,659 · see citing works

The transcription factor Myc controls metabolic reprogramming upon T lymphocyte activation

Wang, R., Dillon, C. P., Shi, L. Z., Milasta, S., Carter, R., Finkelstein, D., McCormick, L. L., Fitzgerald, P., Chi, H., Munger, J., et al. (2011) · Immunity · doi:10.1016/j.immuni.2011.09.021 · Cited by 2,140 · cited 4× · see citing works

HIF1α–dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Treg cells

Shi, L. Z., Wang, R., Huang, G., Vogel, P., Neale, G., Green, D. R., & Chi, H. (2011) · Journal of Experimental Medicine · doi:10.1084/jem.20110278 · Cited by 1,803 · see citing works

mTOR regulates memory CD8 T-cell differentiation

Araki, K., Turner, A. P., Shaffer, V. O., Gangappa, S., Keller, S. A., Bachmann, M. F., Larsen, C. P., & Ahmed, R. (2009) · Nature · doi:10.1038/nature08155 · Cited by 1,575 · see citing works

HIF-1: upstream and downstream of cancer metabolism

Semenza, G. L. (2009) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2009.10.009 · Cited by 1,381 · see citing works

The kinase mTOR regulates the differentiation of helper T cells through the selective activation of signaling by mTORC1 and mTORC2

Delgoffe, G. M., Pollizzi, K. N., Waickman, A. T., Heikamp, E., Meyers, D. J., Horton, M. R., Xiao, B., Worley, P. F., & Powell, J. D. (2011) · Nature Immunology · doi:10.1038/ni.2005 · Cited by 1,111 · see citing works

Tolerance induction in double specific T-cell receptor transgenic mice varies with antigen

Pircher, H., Bürki, K., Lang, R., Hengartner, H., & Zinkernagel, R. M. (1989) · Nature · doi:10.1038/342559a0 · Cited by 1,019 · see citing works

Impaired B and T Cell Antigen Receptor Signaling in p110δ PI 3-Kinase Mutant Mice

Okkenhaug, K., Bilancio, A., Farjot, G., Priddle, H., Sancho, S., Peskett, E., Pearce, W. P., Meek, S. E., Salpekar, A., Waterfield, M. D., et al. (2002) · Science · doi:10.1126/science.1073560 · Cited by 948 · see citing works

Fuel feeds function: energy metabolism and the T-cell response

Fox, C. J., Hammerman, P. S., & Thompson, C. B. (2005) · Nature reviews. Immunology · doi:10.1038/nri1710 · Cited by 841 · see citing works

Interleukin-2 and Inflammation Induce Distinct Transcriptional Programs that Promote the Differentiation of Effector Cytolytic T Cells

Pipkin, M. E., Sacks, J. A., Cruz‐Guilloty, F., Lichtenheld, M. G., Bevan, M. J., & Rao, A. (2010) · Immunity · doi:10.1016/j.immuni.2009.11.012 · Cited by 799 · see citing works

Constitutive class I-restricted exogenous presentation of self antigens in vivo

Kurts, C., Heath, W., Carbone, F., Allison, J., Miller, J. F. A. P., & Kosaka, H. (1996) · Journal of Experimental Medicine · doi:10.1084/jem.184.3.923 · Cited by 730 · see citing works

Direct inhibition of the signaling functions of the mammalian target of rapamycin by the phosphoinositide 3‐kinase inhibitors, wortmannin and LY294002.

Brunn, G. J., Williams, J. M., Sabers, C. J., Wiederrecht, G., Lawrence, J. C., & Abraham, R. T. (1996) · The EMBO Journal · doi:10.1002/j.1460-2075.1996.tb00911.x · Cited by 723 · see citing works

The mTOR Kinase Determines Effector versus Memory CD8+ T Cell Fate by Regulating the Expression of Transcription Factors T-bet and Eomesodermin

Rao, R. R., Li, Q., Odunsi, K., & Shrikant, P. A. (2010) · Immunity · doi:10.1016/j.immuni.2009.10.010 · Cited by 656 · see citing works

Prolonged Interleukin-2Rα Expression on Virus-Specific CD8+ T Cells Favors Terminal-Effector Differentiation In Vivo

Kalia, V., Sarkar, S., Subramaniam, S., Haining, W. N., Smith, K. A., & Ahmed, R. (2010) · Immunity · doi:10.1016/j.immuni.2009.11.010 · Cited by 590 · see citing works

Foxo1 links homing and survival of naive T cells by regulating L-selectin, CCR7 and interleukin 7 receptor

Kerdiles, Y. M., Beisner, D. R., Tinoco, R., Dejean, A. S., Castrillón, D. H., DePinho, R. A., & Hedrick, S. Μ. (2009) · Nature Immunology · doi:10.1038/ni.1689 · Cited by 541 · see citing works

Runx3 and T-box proteins cooperate to establish the transcriptional program of effector CTLs

Cruz‐Guilloty, F., Pipkin, M. E., Djuretic, I. M., Levanon, D., Lotem, J., Lichtenheld, M. G., Groner, Y., & Rao, A. (2009) · The Journal of Experimental Medicine · doi:10.1084/jem.20081242 · Cited by 518 · see citing works

Glucose metabolism in lymphocytes is a regulated process with significant effects on immune cell function and survival

MacIver, N. J., Jacobs, S. R., Wieman, H. L., Wofford, J. A., Coloff, J. L., & Rathmell, J. C. (2008) · Journal of Leukocyte Biology · doi:10.1189/jlb.0108024 · Cited by 501 · see citing works

The Mammalian Target of Rapamycin: Linking T Cell Differentiation, Function, and Metabolism

Powell, J. D., & Delgoffe, G. M. (2010) · Immunity · doi:10.1016/j.immuni.2010.09.002 · Cited by 487 · see citing works

Mammalian Target of Rapamycin Protein Complex 2 Regulates Differentiation of Th1 and Th2 Cell Subsets via Distinct Signaling Pathways

Lee, K., Gudapati, P., Dragovic, S. M., Spencer, C. T., Joyce, S., Killeen, N. P., Magnuson, M. A., & Boothby, M. R. (2010) · Immunity · doi:10.1016/j.immuni.2010.06.002 · Cited by 464 · see citing works

Differential Effects of Physiologically Relevant Hypoxic Conditions on T Lymphocyte Development and Effector Functions

Caldwell, C. C., Kojima, H., Lukashev, D., Armstrong, J., Farber, M., Apasov, S. G., & Sitkovsky, M. V. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.167.11.6140 · Cited by 420 · see citing works

Phosphatidylinositol-3-OH kinase and nutrient-sensing mTOR pathways control T lymphocyte trafficking

Sinclair, L. V., Finlay, D. K., Feijóo, C. G., Cornish, G. H., Gray, A., Ager, A., Okkenhaug, K., Hagenbeek, T. J., Spits, H., & Cantrell, D. A. (2008) · Nature Immunology · doi:10.1038/ni.1603 · Cited by 391 · see citing works

Glucose deprivation inhibits multiple key gene expression events and effector functions in CD8⁺ T cells

Cham, C. M., Driessens, G., O'Keefe, J. P., & Gajewski, T. F. (2008) · European Journal of Immunology · doi:10.1002/eji.200838289 · Cited by 388 · see citing works

Glucose Availability Regulates IFN-γ Production and p70S6 Kinase Activation in CD8+ Effector T Cells

Cham, C. M., & Gajewski, T. F. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.8.4670 · Cited by 359 · see citing works

Cell surface labeling of glucose transporter isoform GLUT4 by bis-mannose photolabel. Correlation with stimulation of glucose transport in rat adipose cells by insulin and phorbol ester.

Holman, G. D., Kozka, I. J., CLARK, A. E., Flower, C. J., Saltis, J., Habberfield, A. D., Simpson, I. A., & Cushman, S. W. (1990) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)44734-x · Cited by 329 · see citing works

Protein Kinase B Controls Transcriptional Programs that Direct Cytotoxic T Cell Fate but Is Dispensable for T Cell Metabolism

Macintyre, A. N., Finlay, D. K., Preston, G., Sinclair, L. V., Waugh, C. M., Tamas, P., Feijóo, C. G., Okkenhaug, K., & Cantrell, D. A. (2011) · Immunity · doi:10.1016/j.immuni.2011.01.012 · Cited by 274 · see citing works

Deficiency of PDK1 in cardiac muscle results in heart failure and increased sensitivity to hypoxia

Mora, A., Davies, A. M., Bertrand, L., Sharif, I., Budas, G. R., Jovanović, A., Mouton, V., Kahn, C. R., Lucocq, J. M., Gray, G. A., et al. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg469 · Cited by 194 · see citing works

FOXO1 Regulates L-Selectin and a Network of Human T Cell Homing Molecules Downstream of Phosphatidylinositol 3-Kinase

Fabre, S., Carrette, F., Chen, J., Lang, V., Sémichon, M., Denoyelle, C., Lazar, V., Cagnard, N., Dubart‐Kupperschmitt, A., Mangeney, M., et al. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.181.5.2980 · Cited by 187 · see citing works

Phosphoproteomic analysis reveals an intrinsic pathway for the regulation of histone deacetylase 7 that controls the function of cytotoxic T lymphocytes

Navarro, M. N., Goebel, J., Feijoo‐Carnero, C., MORRICE, N. A., & Cantrell, D. A. (2011) · Nature Immunology · doi:10.1038/ni.2008 · Cited by 106 · see citing works

Phosphoinositide (3,4,5)-Triphosphate Binding to Phosphoinositide-Dependent Kinase 1 Regulates a Protein Kinase B/Akt Signaling Threshold That Dictates T-Cell Migration, Not Proliferation

Waugh, C. M., Sinclair, L. V., Finlay, D. K., Bayascas, J. R., & Cantrell, D. A. (2009) · Molecular and Cellular Biology · doi:10.1128/mcb.00585-09 · Cited by 77 · see citing works

Energy metabolism and T-cell-mediated cytolysis. I. Synergism between inhibitors of respiration and glycolysis.

MacDonald, H. R., & Koch, C. J. (1977) · The Journal of Experimental Medicine · doi:10.1084/jem.146.3.698 · Cited by 60 · see citing works

Targeted ablation of Arnt in mouse epidermis results in profound defects in desquamation and epidermal barrier function

Geng, S., Mezentsev, A., Kalachikov, S. M., Raith, K., Roop, D. R., & Panteleyev, A. A. (2006) · Journal of Cell Science · doi:10.1242/jcs.03282 · Cited by 48 · see citing works

Characterization of MRFAP1 Turnover and Interactions Downstream of the NEDD8 Pathway

Larance, M., Kirkwood, K. J., Xirodimas, D. P., Lundberg, E. K., Uhlén, M., & Lamond, A. I. (2011) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m111.014407 · Cited by 26 · see citing works

Hypoxic microenvironment in cancer: molecular mechanisms and therapeutic interventions

Chen, Z., Han, F., Du, Y., Shi, H., & Zhou, W. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01332-8 · Cited by 1,612 · see citing works

Phosphoenolpyruvate Is a Metabolic Checkpoint of Anti-tumor T Cell Responses

Ho, P.-C., Bihuniak, J. D., Macintyre, A. N., Staron, M., Liu, X., Amezquita, R., Tsui, Y.-C., Cui, G., Micevic, G., Perales, J. C., et al. (2015) · Cell · doi:10.1016/j.cell.2015.08.012 · Cited by 1,462 · see citing works

Distinct Signaling of Coreceptors Regulates Specific Metabolism Pathways and Impacts Memory Development in CAR T Cells

Kawalekar, O. U., O’Connor, R. S., Fraietta, J. A., Guo, L., McGettigan, S. E., Posey, A. D., Patel, P. R., Guedan, S., Scholler, J., Keith, B., et al. (2016) · Immunity · doi:10.1016/j.immuni.2016.01.021 · Cited by 1,234 · see citing works

Metabolic Instruction of Immunity

Buck, M. D., Sowell, R., Kaech, S. M., & Pearce, E. L. (2017) · Cell · doi:10.1016/j.cell.2017.04.004 · Cited by 1,232 · see citing works

T cell metabolism drives immunity

Buck, M. D., O’Sullivan, D., & Pearce, E. L. (2015) · The Journal of Experimental Medicine · doi:10.1084/jem.20151159 · Cited by 1,190 · see citing works

HIF transcription factors, inflammation, and immunity

Palazon, A., Goldrath, A. W., Nizet, V., & Johnson, R. S. (2014) · Immunity · doi:10.1016/j.immuni.2014.09.008 · Cited by 1,195 · see citing works

Signaling and Function of Interleukin-2 in T Lymphocytes

Ross, S. H., & Cantrell, D. A. (2018) · Annual Review of Immunology · doi:10.1146/annurev-immunol-042617-053352 · Cited by 979 · see citing works

Inhibiting glycolytic metabolism enhances CD8+ T cell memory and antitumor function

Sukumar, M., Liu, J., Ji, Y., Subramanian, M., Crompton, J. G., Yu, Z., Roychoudhuri, R., Palmer, D. C., Muranski, P., Karoly, E. D., et al. (2013) · Journal of Clinical Investigation · doi:10.1172/jci69589 · Cited by 952 · see citing works

Control of amino-acid transport by antigen receptors coordinates the metabolic reprogramming essential for T cell differentiation

Sinclair, L. V., Rolf, J., Emslie, E., Shi, Y.-B., Taylor, P. M., & Cantrell, D. A. (2013) · Nature Immunology · doi:10.1038/ni.2556 · Cited by 930 · see citing works

Metabolism of immune cells in cancer

Leone, R. D., & Powell, J. D. (2020) · Nature Reviews Cancer · doi:10.1038/s41568-020-0273-y · Cited by 877 · see citing works

Keeping It All Going—Complement Meets Metabolism

Kolev, M. V., & Kemper, C. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.00001 · Cited by 819 · see citing works

The role of HIF in immunity and inflammation

McGettrick, A. F., & O’Neill, L. A. J. (2020) · Cell Metabolism · doi:10.1016/j.cmet.2020.08.002 · Cited by 768 · see citing works

Dominant-activating germline mutations in the gene encoding the PI(3)K catalytic subunit p110δ result in T cell senescence and human immunodeficiency

Lucas, C. L., Kuehn, H. S., Zhao, F. R., Niemela, J. E., Deenick, E. K., Palendira, U., Avery, D. T., Moens, L., Cannons, J. L., Biancalana, M., et al. (2013) · Nature Immunology · doi:10.1038/ni.2771 · Cited by 677 · see citing works

Immune Landscape of Viral- and Carcinogen-Driven Head and Neck Cancer

Cillo, A. R., Kürten, C. H. L., Tabib, T., Qi, Z., Onkar, S., Wang, T., Liu, A., Duvvuri, U., Kim, S., Soose, R. J., et al. (2020) · Immunity · doi:10.1016/j.immuni.2019.11.014 · Cited by 654 · see citing works

Hypoxia-inducible factors enhance the effector responses of CD8(+) T cells to persistent antigen

Doedens, A. L., Phan, A. T., Stradner, M. H., Fujimoto, J. K., Nguyen, J. V., Yang, E., Johnson, R. S., & Goldrath, A. W. (2013) · Nature Immunology · doi:10.1038/ni.2714 · Cited by 660 · see citing works

Glycolysis – a key player in the inflammatory response

Soto‐Heredero, G., Heras, M. M. G. D. L., Gabandé‐Rodríguez, E., Oller, J., & Mittelbrunn, M. (2020) · FEBS Journal · doi:10.1111/febs.15327 · Cited by 645 · see citing works

mTORC1 signaling and the metabolic control of cell growth

Ben‐Sahra, I., & Manning, B. D. (2017) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2017.02.012 · Cited by 641 · see citing works

Metabolic reprogramming of natural killer cells in obesity limits antitumor responses

Michelet, X., Dyck, L., Hogan, A. E., Loftus, R. M., Duquette, D., Wei, K., Beyaz, S., Tavakkoli, A., Foley, C., Donnelly, R., et al. (2018) · Nature Immunology · doi:10.1038/s41590-018-0251-7 · Cited by 624 · see citing works

Enhancing CD8+ T Cell Fatty Acid Catabolism within a Metabolically Challenging Tumor Microenvironment Increases the Efficacy of Melanoma Immunotherapy

Zhang, Y., Kurupati, R. K., Liu, L., Zhou, X., Zhang, G., Hudaihed, A., Filisio, F., Giles‐Davis, W., Xu, X., Karakousis, G. C., et al. (2017) · Cancer Cell · doi:10.1016/j.ccell.2017.08.004 · Cited by 614 · see citing works

The metabolic checkpoint kinase mTOR is essential for IL-15 signaling during the development and activation of NK cells

Marçais, A., Cherfils‐Vicini, J., Viant, C., Degouve, S., Viel, S., Fenis, A., Rabilloud, J., Mayol, K., Tavares, A., Bienvenu, J., et al. (2014) · Nature Immunology · doi:10.1038/ni.2936 · Cited by 611 · see citing works

Molecular regulation of effector and memory T cell differentiation

Chang, J. T., Wherry, E. J., & Goldrath, A. W. (2014) · Nature Immunology · doi:10.1038/ni.3031 · Cited by 578 · see citing works

Redox regulation of the immune response

Morris, G., Gevezova, M., Sarafian, V. S., & Maes, M. H. J. (2022) · Cellular and Molecular Immunology · doi:10.1038/s41423-022-00902-0 · Cited by 600 · see citing works

The Warburg effect then and now: From cancer to inflammatory diseases

Pålsson‐McDermott, E. M., & O'Neill, L. A. J. (2013) · BioEssays · doi:10.1002/bies.201300084 · Cited by 538 · see citing works

Metabolic modeling of single Th17 cells reveals regulators of autoimmunity

Wagner, A., Wang, C., Fessler, J., DeTomaso, D., Avila-Pacheco, J., Kaminski, J., Zaghouani, S., Christian, E., Thakore, P., Schellhaass, B., et al. (2021) · Cell · doi:10.1016/j.cell.2021.05.045 · Cited by 524 · see citing works

Glutamine-dependent α-ketoglutarate production regulates the balance between T helper 1 cell and regulatory T cell generation

Klysz, D., Tai, X., Robert, P. A., Craveiro, M., Cretenet, G., Oburoglu, L., Mongellaz, C., Floess, S., Fritz, V., Matias, M. I., et al. (2015) · Science Signaling · doi:10.1126/scisignal.aab2610 · Cited by 522 · see citing works

An HIF-1α/VEGF-A Axis in Cytotoxic T Cells Regulates Tumor Progression

Palazon, A., Tyrakis, P. A., Macias, D., Veliça, P., Rundqvist, H., Fitzpatrick, S., Vojnovic, N., Phan, A. T., Loman, N., Hedenfalk, I., et al. (2017) · Cancer Cell · doi:10.1016/j.ccell.2017.10.003 · Cited by 521 · see citing works

Eosinophils orchestrate cancer rejection by normalizing tumor vessels and enhancing infiltration of CD8+ T cells

Carretero, R., Sektioglu, I. M., Garbi, N., Salgado, O. C., Beckhove, P., & Hämmerling, G. J. (2015) · Nature Immunology · doi:10.1038/ni.3159 · Cited by 501 · see citing works

Redox regulation of immunometabolism

Muri, J., & Köpf, M. (2020) · Nature reviews. Immunology · doi:10.1038/s41577-020-00478-8 · Cited by 501 · see citing works

Rapid effector function of memory CD8+ T cells requires an immediate-early glycolytic switch

Gubser, P. M., Bantug, G. R., Razik, L., Fischer, M., Dimeloe, S., Höenger, G., Müller-Durovic, B., Jauch, A., & Hess, C. (2013) · Nature Immunology · doi:10.1038/ni.2687 · Cited by 487 · see citing works

mTORC1-Dependent Metabolic Reprogramming Is a Prerequisite for NK Cell Effector Function

Donnelly, R. P., Loftus, R. M., Keating, S. E., Liou, K. T., Biron, C. A., Gardiner, C. M., & Finlay, D. K. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1401558 · Cited by 480 · see citing works

Metabolic pathways in T cell activation and lineage differentiation

Almeida, L., Lochner, M., Berod, L., & Sparwasser, T. D. (2016) · Seminars in Immunology · doi:10.1016/j.smim.2016.10.009 · Cited by 475 · see citing works

Obesity, Inflammation, and Immune System in Osteoarthritis

Nedunchezhiyan, U., Varughese, I., Sun, A. R., Wu, X., Crawford, R., & Prasadam, I. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.907750 · Cited by 487 · see citing works

Autophagy enforces functional integrity of regulatory T cells by coupling environmental cues and metabolic homeostasis

Wei, J., Long, L., Yang, K., Guy, C., Shrestha, S., Chen, Z., Wu, C., Vogel, P., Neale, G., Green, D. R., et al. (2016) · Nature Immunology · doi:10.1038/ni.3365 · Cited by 470 · see citing works

Immunometabolism: Cellular Metabolism Turns Immune Regulator

Loftus, R. M., & Finlay, D. K. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.r115.693903 · Cited by 446 · see citing works

Signaling by the Phosphoinositide 3-Kinase Family in Immune Cells

Okkenhaug, K. (2013) · Annual Review of Immunology · doi:10.1146/annurev-immunol-032712-095946 · Cited by 446 · see citing works

Immunometabolism and natural killer cell responses

O’Brien, K., & Finlay, D. K. (2019) · Nature reviews. Immunology · doi:10.1038/s41577-019-0139-2 · Cited by 435 · see citing works

S-2-hydroxyglutarate regulates CD8(+) T-lymphocyte fate

Tyrakis, P. A., Palazon, A., Macias, D., Lee, K. L., Phan, A. T., Veliça, P., You, J., Chia, G. S., Sim, J., Doedens, A., et al. (2016) · Nature · doi:10.1038/nature20165 · Cited by 433 · see citing works

Regulation of inflammation by the antioxidant haem oxygenase 1

Campbell, N. K., Fitzgerald, H. K., & Dunne, A. (2021) · Nature reviews. Immunology · doi:10.1038/s41577-020-00491-x · Cited by 428 · see citing works

The transcription factor IRF4 is essential for TCR affinity–mediated metabolic programming and clonal expansion of T cells

Man, K., Miasari, M., Shi, W., Xin, A., Henstridge, D. C., Preston, S., Pellegrini, M., Belz, G. T., Smyth, G. K., Febbraio, M. A., et al. (2013) · Nature Immunology · doi:10.1038/ni.2710 · Cited by 407 · see citing works

Hypoxia: a key player in antitumor immune response. A Review in the Theme: Cellular Responses to Hypoxia

Noman, M. Z., Hasmim, M., Messai, Y., Terry, S., Kiéda, C., Janji, B., & Chouaı̈b, S. (2015) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00207.2015 · Cited by 405 · see citing works

Coupling Krebs cycle metabolites to signalling in immunity and cancer

Ryan, D. G., Murphy, M. P., Frezza, C., Prag, H. A., Chouchani, E. T., O’Neill, L. A., & Mills, E. L. (2018) · Nature Metabolism · doi:10.1038/s42255-018-0014-7 · Cited by 398 · see citing works

T Cell Exit from Quiescence and Differentiation into Th2 Cells Depend on Raptor-mTORC1-Mediated Metabolic Reprogramming

Yang, K., Shrestha, S., Zeng, H., Karmaus, P. W. F., Neale, G. A. M., Vogel, P., Guertin, D. A., Lamb, R. F., & Chi, H. (2013) · Immunity · doi:10.1016/j.immuni.2013.09.015 · Cited by 389 · see citing works

Mitochondrial Membrane Potential Identifies Cells with Enhanced Stemness for Cellular Therapy

Sukumar, M., Liu, J., Mehta, G. U., Patel, S. J., Roychoudhuri, R., Crompton, J. G., Klebanoff, C. A., Ji, Y., Li, P., Yu, Z., et al. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2015.11.002 · Cited by 391 · see citing works

The Transcription Factor FoxO1 Sustains Expression of the Inhibitory Receptor PD-1 and Survival of Antiviral CD8+ T Cells during Chronic Infection

Staron, M. M., Gray, S. M., Marshall, H. D., Parish, I. A., Chen, J. H., Perry, C. J., Cui, G., Li, M. O., & Kaech, S. M. (2014) · Immunity · doi:10.1016/j.immuni.2014.10.013 · Cited by 384 · see citing works

Amino acid-dependent cMyc expression is essential for NK cell metabolic and functional responses in mice

Loftus, R. M., Aßmann, N., Kedia-Mehta, N., O’Brien, K., Garcia, A., Gillespie, C. S., Hukelmann, J. L., Oefner, P. J., Lamond, A. I., Gardiner, C. M., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-04719-2 · Cited by 383 · see citing works

Integrating canonical and metabolic signalling programmes in the regulation of T cell responses

Pollizzi, K. N., & Powell, J. D. (2014) · Nature reviews. Immunology · doi:10.1038/nri3701 · Cited by 379 · see citing works

Hypoxic stress: obstacles and opportunities for innovative immunotherapy of cancer

Chouaı̈b, S., Noman, M. Z., Kosmatopoulos, K., & Curran, M. A. (2016) · Oncogene · doi:10.1038/onc.2016.225 · Cited by 366 · see citing works

PD1Hi CD8+ T cells correlate with exhausted signature and poor clinical outcome in hepatocellular carcinoma

Ma, J., Zheng, B., Goswami, S., Lu, M., Zhang, D., Cao, C., Li, T., Zhu, F., Ma, L., Zhang, Z., et al. (2019) · Journal for ImmunoTherapy of Cancer · doi:10.1186/s40425-019-0814-7 · Cited by 364 · see citing works

Glucose and glutamine fuel protein O-GlcNAcylation to control T cell self-renewal and malignancy

Swamy, M., Pathak, S., Grzes, K. M., Damerow, S., Sinclair, L. V., van Aalten, D. M. F., & Cantrell, D. A. (2016) · Nature Immunology · doi:10.1038/ni.3439 · Cited by 353 · see citing works

mTORC1 and mTORC2 Kinase Signaling and Glucose Metabolism Drive Follicular Helper T Cell Differentiation

Zeng, H., Cohen, S., Guy, C. S., Shrestha, S., Neale, G. A. M., Brown, S. A., Cloer, C., Kishton, R. J., Gao, X., Youngblood, B., et al. (2016) · Immunity · doi:10.1016/j.immuni.2016.08.017 · Cited by 347 · see citing works

Metabolic signaling in T cells

Shyer, J. A., Flavell, R. A., & Bailis, W. (2020) · Cell Research · doi:10.1038/s41422-020-0379-5 · Cited by 334 · see citing works

Warburg effect in colorectal cancer: the emerging roles in tumor microenvironment and therapeutic implications

Zhong, X., He, X., Wang, Y., Hu, Z., Huang, H., Zhao, S., Wei, P., & Li, D. (2022) · Journal of Hematology & Oncology · doi:10.1186/s13045-022-01358-5 · Cited by 340 · see citing works

Mitochondrial dysfunction promotes the transition of precursor to terminally exhausted T cells through HIF-1α-mediated glycolytic reprogramming

Wu, H., Zhao, X., Hochrein, S. M., Eckstein, M., Gubert, G. F., Knöpper, K., Mansilla, A. M., Öner, A., Doucet-Ladevèze, R., Schmitz, W., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-42634-3 · Cited by 334 · see citing works

Immunometabolic Interplay in the Tumor Microenvironment

Kaymak, I., Williams, K. S., Cantor, J. R., & Jones, R. G. (2020) · Cancer Cell · doi:10.1016/j.ccell.2020.09.004 · Cited by 330 · see citing works

Metabolic Reprogramming Supports IFN-γ Production by CD56bright NK Cells

Keating, S. E., Zaiatz-Bittencourt, V., Loftus, R. M., Keane, C., Brennan, K., Finlay, D. K., & Gardiner, C. M. (2016) · The Journal of Immunology · doi:10.4049/jimmunol.1501783 · Cited by 326 · see citing works

Metabolic regulation of inflammation

Gaber, T., Strehl, C., & Buttgereit, F. (2017) · Nature Reviews Rheumatology · doi:10.1038/nrrheum.2017.37 · Cited by 320 · see citing works

T cell metabolic fitness in antitumor immunity

Siska, P. J., & Rathmell, J. C. (2015) · Trends in Immunology · doi:10.1016/j.it.2015.02.007 · Cited by 315 · see citing works

Immunity, Hypoxia, and Metabolism–the Ménage à Trois of Cancer: Implications for Immunotherapy

Riera-Domingo, C., Audigé, A., Granja, S., Cheng, W.-C., Ho, P.-C., Baltazar, F., Stockmann, C., & Mazzone, M. (2020) · Physiological Reviews · doi:10.1152/physrev.00018.2019 · Cited by 310 · see citing works

Single-cell metabolic profiling of human cytotoxic T cells

Hartmann, F. J., Mrdjen, D., McCaffrey, E., Glass, D. R., Greenwald, N. F., Bharadwaj, A., Khair, Z., Verberk, S. G. S., Baranski, A., Baskar, R., et al. (2020) · Nature Biotechnology · doi:10.1038/s41587-020-0651-8 · Cited by 310 · see citing works

Targeting metabolism to regulate immune responses in autoimmunity and cancer

Patel, C. H., Leone, R. D., Horton, M. R., & Powell, J. D. (2019) · Nature Reviews Drug Discovery · doi:10.1038/s41573-019-0032-5 · Cited by 307 · see citing works

Linoleic acid potentiates CD8+ T cell metabolic fitness and antitumor immunity

Lauson, C. B. N., Tiberti, S., Corsetto, P. A., Conte, F., Tyagi, P., Machwirth, M., Ebert, S., Loffreda, A., Scheller, L., Sheta, D., et al. (2023) · Cell Metabolism · doi:10.1016/j.cmet.2023.02.013 · Cited by 294 · see citing works

Competition for nutrients and its role in controlling immune responses

Kedia-Mehta, N., & Finlay, D. K. (2019) · Nature Communications · doi:10.1038/s41467-019-10015-4 · Cited by 287 · see citing works

Metabolic control of regulatory T cell development and function

Zeng, H., & Chi, H. (2014) · Trends in Immunology · doi:10.1016/j.it.2014.08.003 · Cited by 275 · see citing works

mTORC 1 and mTORC 2 as regulators of cell metabolism in immunity

Linke, M., Fritsch, S. D., Sukhbaatar, N., Hengstschläger, M., & Weichhart, T. (2017) · FEBS Letters · doi:10.1002/1873-3468.12711 · Cited by 271 · see citing works

Distinct Metabolic Requirements of Exhausted and Functional Virus-Specific CD8 T Cells in the Same Host

Schurich, A., Pallett, L. J., Jajbhay, D., Wijngaarden, J. E., Otano, I., Gill, U. S., Hansi, N. K., Kennedy, P. T. F., Nastouli, E., Gilson, R. J. C., et al. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.06.078 · Cited by 258 · see citing works

Targeting T cell metabolism for therapy

O’Sullivan, D., & Pearce, E. L. (2015) · Trends in Immunology · doi:10.1016/j.it.2014.12.004 · Cited by 251 · see citing works

Signaling networks in immunometabolism

Saravia, J., Raynor, J. L., Chapman, N. M., Lim, S. A., & Chi, H. (2020) · Cell Research · doi:10.1038/s41422-020-0301-1 · Cited by 252 · see citing works

The cytotoxic T cell proteome and its shaping by the kinase mTOR

Hukelmann, J. L., Anderson, K. E., Sinclair, L. V., Grzes, K. M., Murillo, A. B., Hawkins, P. T., Stephens, L. R., Lamond, A. I., & Cantrell, D. A. (2016) · Nature Immunology · doi:10.1038/ni.3314 · Cited by 249 · see citing works

Potent and selective chemical probe of hypoxic signalling downstream of HIF-α hydroxylation via VHL inhibition

Frost, J., Galdeano, C., Soares, P., Gadd, M. S., Grzes, K. M., Ellis, L. C. J., Epemolu, O., Shimamura, S., Bantscheff, M., Grandi, P., et al. (2016) · Nature Communications · doi:10.1038/ncomms13312 · Cited by 242 · see citing works

Tumor stroma: a complexity dictated by the hypoxic tumor microenvironment

Casazza, A., Conza, G. D., Wenes, M., Finisguerra, V., Deschoemaeker, S., & Mazzone, M. (2013) · Oncogene · doi:10.1038/onc.2013.121 · Cited by 243 · see citing works

Metabolism, Activity, and Targeting of D- and L-2-Hydroxyglutarates

Ye, D., Guan, K.-L., & Xiong, Y. (2018) · Trends in Cancer · doi:10.1016/j.trecan.2017.12.005 · Cited by 242 · see citing works

Heterogeneity in Cancer Metabolism: New Concepts in an Old Field

Gentric, G., Mieulet, V., & Mechta‐Grigoriou, F. (2016) · Antioxidants and Redox Signaling · doi:10.1089/ars.2016.6750 · Cited by 237 · see citing works

Inflammation and Hypoxia: HIF and PHD Isoform Selectivity

Watts, E., & Walmsley, S. R. (2018) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2018.10.006 · Cited by 236 · see citing works

Interferon Regulatory Factor 4 Sustains CD8+ T Cell Expansion and Effector Differentiation

Yao, S., Buzo, B. F. D., Pham, D., Jiang, L., Taparowsky, E. J., Kaplan, M. H., & Sun, J. (2013) · Immunity · doi:10.1016/j.immuni.2013.10.007 · Cited by 236 · see citing works

Asymmetric inheritance of mTORC1 kinase activity during division dictates CD8+ T cell differentiation

Pollizzi, K. N., Sun, I., Patel, C. H., Lo, Y.-C., Oh, M. H., Waickman, A. T., Tam, A. J., Blosser, R. L., Wen, J., Delgoffe, G. M., et al. (2016) · Nature Immunology · doi:10.1038/ni.3438 · Cited by 231 · see citing works

Influence of Inflammation in the Process of T Lymphocyte Differentiation: Proliferative, Metabolic, and Oxidative Changes

Moro‐García, M. A., Mayo, J. C., Sainz, R. M., & Alonso‐Arias, R. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00339 · Cited by 232 · see citing works

Quantitative analysis of T cell proteomes and environmental sensors during T cell differentiation

Howden, A. J. M., Hukelmann, J. L., Brenes, A., Spinelli, L., Sinclair, L. V., Lamond, A. I., & Cantrell, D. A. (2019) · Nature Immunology · doi:10.1038/s41590-019-0495-x · Cited by 231 · see citing works

Lactate dehydrogenase inhibition synergizes with IL-21 to promote CD8 + T cell stemness and antitumor immunity

Hermans, D., Gautam, S., García‐Cañaveras, J. C., Gromer, D. J., Mitra, S., Spolski, R. J., Li, P., Christensen, S. M., Nguyen, R., Lin, J., et al. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1920413117 · Cited by 230 · see citing works

Inhibition of AKT signaling uncouples T cell differentiation from expansion for receptor-engineered adoptive immunotherapy

Klebanoff, C. A., Crompton, J. G., Leonardi, A. J., Yamamoto, T. N., Chandran, S. S., Eil, R. L., Sukumar, M., Vodnala, S. K., Hu, J., Ji, Y., et al. (2017) · JCI Insight · doi:10.1172/jci.insight.95103 · Cited by 225 · see citing works

Antigen receptor control of methionine metabolism in T cells

Sinclair, L. V., Howden, A. J. M., Brenes, A. J., Spinelli, L., Hukelmann, J. L., Macintyre, A. N., Liu, X., Thomson, S., Taylor, P. M., Rathmell, J. C., et al. (2019) · eLife · doi:10.7554/elife.44210 · Cited by 222 · see citing works

Hypoxia-dependent regulation of inflammatory pathways in immune cells

Taylor, C. T., Doherty, G. A., Fallon, P. G., & Cummins, E. P. (2016) · Journal of Clinical Investigation · doi:10.1172/jci84433 · Cited by 217 · see citing works

mTOR activation is a biomarker and a central pathway to autoimmune disorders, cancer, obesity, and aging

Perl, A. (2015) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.12756 · Cited by 218 · see citing works

mTOR Regulation of Glycolytic Metabolism in T Cells

Salmond, R. J. (2018) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2018.00122 · Cited by 211 · see citing works

Direct Type I IFN but Not MDA5/TLR3 Activation of Dendritic Cells Is Required for Maturation and Metabolic Shift to Glycolysis after Poly IC Stimulation

Pantel, A. R., Teixeira, A., Haddad, E. K., Wood, E. G., Steinman, R. M., & Longhi, M. P. (2014) · PLoS Biology · doi:10.1371/journal.pbio.1001759 · Cited by 210 · see citing works

Regulation of Effector and Memory CD8 T Cell Differentiation by IL-2—A Balancing Act

Kalia, V., & Sarkar, S. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02987 · Cited by 209 · see citing works

Metabolic Barriers to T Cell Function in Tumors

Sugiura, A., & Rathmell, J. C. (2018) · The Journal of Immunology · doi:10.4049/jimmunol.1701041 · Cited by 208 · see citing works

Constitutive Glycolytic Metabolism Supports CD8+ T Cell Effector Memory Differentiation during Viral Infection

Phan, A. T., Doedens, A. L., Palazón, A., Tyrakis, P. A., Cheung, K. P., Johnson, R. S., & Goldrath, A. W. (2016) · Immunity · doi:10.1016/j.immuni.2016.10.017 · Cited by 201 · see citing works

Hypoxia, Metabolism and Immune Cell Function

Krzywińska, E., & Stockmann, C. (2018) · Biomedicines · doi:10.3390/biomedicines6020056 · Cited by 207 · see citing works

Regulation of T cells by mTOR: the known knowns and the known unknowns

Pollizzi, K. N., & Powell, J. D. (2014) · Trends in Immunology · doi:10.1016/j.it.2014.11.005 · Cited by 196 · see citing works

mTOR signaling in the differentiation and function of regulatory and effector T cells

Zeng, H., & Chi, H. (2017) · Current Opinion in Immunology · doi:10.1016/j.coi.2017.04.005 · Cited by 194 · see citing works

Glutathione de novo synthesis but not recycling process coordinates with glutamine catabolism to control redox homeostasis and directs murine T cell differentiation

Lian, G., Gnanaprakasam, J. R., Wang, T., Wu, R., Chen, X., Liu, L., Shen, Y., Yang, M., Yang, J. J. J., Chen, Y., et al. (2018) · eLife · doi:10.7554/elife.36158 · Cited by 199 · see citing works

NFATc1 controls the cytotoxicity of CD8+ T cells

Klein‐Hessling, S., Muhammad, K., Klein, M., Pusch, T., Rudolf, R., Flöter, J., Qureischi, M., Beilhack, A., Vaeth, M., Kummerow, C., et al. (2017) · Nature Communications · doi:10.1038/s41467-017-00612-6 · Cited by 193 · see citing works

mTOR signaling at the crossroads of environmental signals and T‐cell fate decisions

Huang, H., Long, L., Zhou, P., Chapman, N. M., & Chi, H. (2020) · Immunological Reviews · doi:10.1111/imr.12845 · Cited by 193 · see citing works

Metabolism at the crossroads of inflammation and fibrosis in chronic kidney disease

Miguel, V., Shaw, I., & Kramann, R. (2024) · Nature Reviews Nephrology · doi:10.1038/s41581-024-00889-z · Cited by 206 · see citing works

Bcl-6 directly represses the gene program of the glycolysis pathway

Oestreich, K. J., Read, K. A., Gilbertson, S. E., Hough, K. P., McDonald, P. W., Krishnamoorthy, V., & Weinmann, A. S. (2014) · Nature Immunology · doi:10.1038/ni.2985 · Cited by 189 · see citing works

Glucose, glycolysis and lymphocyte responses

Donnelly, R. P., & Finlay, D. K. (2015) · Molecular Immunology · doi:10.1016/j.molimm.2015.07.034 · Cited by 181 · see citing works

Itk-mediated integration of T cell receptor and cytokine signaling regulates the balance between Th17 and regulatory T cells

Gómez‐Rodríguez, J., Wohlfert, E. A., Handon, R., Meylan, F., Wu, J. Z., Anderson, S. M., Kirby, M., Belkaid, Y., & Schwartzberg, P. L. (2014) · The Journal of Experimental Medicine · doi:10.1084/jem.20131459 · Cited by 182 · see citing works

Glucose represses dendritic cell-induced T cell responses

Lawless, S. J., Kedia-Mehta, N., Walls, J. F., McGarrigle, R., Convery, O., Sinclair, L. V., Navarro, M. N., Murray, J. T., & Finlay, D. K. (2017) · Nature Communications · doi:10.1038/ncomms15620 · Cited by 181 · see citing works

Functions of Thrombospondin-1 in the Tumor Microenvironment

Kaur, S., Bronson, S. M., Pal-Nath, D., Miller, T. W., Soto‐Pantoja, D. R., & Roberts, D. D. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22094570 · Cited by 177 · see citing works

Single cell tuning of Myc expression by antigen receptor signal strength and interleukin‐2 in T lymphocytes

Preston, G., Sinclair, L. V., Kaskar, A., Hukelmann, J. L., Navarro, M. N., Ferrero, I., MacDonald, H. R., Cowling, V. H., & Cantrell, D. A. (2015) · The EMBO Journal · doi:10.15252/embj.201490252 · Cited by 169 · see citing works

mTORC1 regulates CD8+ T-cell glucose metabolism and function independently of PI3K and PKB

Finlay, D. K. (2013) · Biochemical Society Transactions · doi:10.1042/bst20120359 · Cited by 22 · see citing works

Regulatory T Cell Migration Is Dependent on Glucokinase-Mediated Glycolysis

Kishore, M., Cheung, K. C.-P., Fu, H., Bonacina, F., Wang, G., Coe, D., Ward, E. J., Colamatteo, A., Jangani, M., Baragetti, A., et al. (2018) · Immunity · doi:10.1016/j.immuni.2018.03.034 · Cited by 46 · see citing works

Acylglycerol Kinase Maintains Metabolic State and Immune Responses of CD8+ T Cells

Hu, Z., Qu, G., Yu, X., Jiang, H., Teng, X.-L., Ding, L., Hu, Q., Guo, X., Zhou, Y., Wang, F., et al. (2019) · Cell Metabolism · doi:10.1016/j.cmet.2019.05.016 · Cited by 87 · see citing works

The energy sensitive kinase mTOR regulates T-bet mediated heritable type 1 effector cell fate of CD8 T cells (83.1)

Rao, R. R., & Shrikant, P. A. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.182.supp.83.1

Regulators of Glucose Metabolism in CD4+ and CD8+ T Cells

Palmer, C. S., Hussain, T., Duette, G., Weller, T. J., Ostrowski, M., Sada‐Ovalle, I., & Crowe, S. M. (2015) · International Reviews of Immunology · doi:10.3109/08830185.2015.1082178 · Cited by 78 · see citing works