The DOI matches its Crossref record; 248 of the 248 references it cites were found in a registry or an index.
Immunotherapy for glioblastoma: current state, challenges, and future perspectives
Open accessAbstract
Glioblastoma (GBM) is an aggressive and lethal type of brain tumor in human adults. The standard of care offers minimal clinical benefit, and most GBM patients experience tumor recurrence after treatment. In recent years, significant advancements have been made in the development of novel immunotherapies or other therapeutic strategies that can overcome immunotherapy resistance in many advanced cancers. However, the benefit of immune-based treatments in GBM is limited because of the unique brain immune profiles, GBM cell heterogeneity, and immunosuppressive tumor microenvironment. In this review, we present a detailed overview of current immunotherapeutic strategies and discuss the challenges and potential molecular mechanisms underlying immunotherapy resistance in GBM. Furthermore, we provide an in-depth discussion regarding the strategies that can overcome immunotherapy resistance in GBM, which will likely require combination therapies.
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Cites
PD-1 and PD-L1 Immune Checkpoint Blockade to Treat Breast Cancer
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Self-citation
Cited by
Preclinical development of an mRNA-based multiepitope immunotherapeutic for glioblastoma
Lutz, J., Feist, R. K., Sonntag, T., Peguero-Sánchez, E., Wolter, K., Bick, R., Bauer, J., Walz, J. S., & Heidenreich, R. (2025) · Cancer Immunology, Immunotherapy · doi:10.1007/s00262-025-04178-x · Cited by 9
Metadata
- Authors
- Liu, Y., Zhou, F., Ali, H., Lathia, J. D., & Chen, P.
- Venue
- Cellular & Molecular Immunology
- Published
- 2024-10-15
- Volume
- 21
- Issue
- 12
- Pages
- 1354-1375
- ISSN
- 1672-7681 (ISSN-L)
- 2042-0226
- OpenAlex
- W4403432106
- Cited by
- 336
- References
- 248
- FWCI
- 78.17
- Type
- journal article
- Language
- en
- Open access
- hybrid
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