Contribution of afferent renal nerve signals to acute and chronic blood pressure regulation in stroke-prone spontaneously hypertensive rats
Open accessAbstract
The activation of sympathetic nervous system plays a critical role in the development of hypertension. The input from afferent renal nerves may affect central sympathetic outflow; however, its contribution to the development of hypertension remains unclear. We investigated the role of afferent renal nerves in acute and chronic blood pressure regulation using normotensive Wistar-Kyoto rats (WKY) and stroke-prone spontaneously hypertensive rats (SHRSP). Acute chemical stimulation of afferent renal nerves elicited larger increases in blood pressure and renal sympathetic nerve activity in young 9-week-old SHRSP compared to WKY. Selective afferent renal denervation (ARDN) and conventional total renal denervation (TRDN) ablating both afferent and efferent nerves in young SHRSP revealed that only TRDN, but not ARDN, chronically attenuated blood pressure elevation. ARDN did not affect plasma renin activity or plasma angiotensin II levels, whereas TRDN decreased both. Neither TRDN nor ARDN affected central sympathetic outflow and systemic sympathetic activity determined by neuronal activity in the parvocellular region of hypothalamic paraventricular nucleus and rostral ventrolateral medulla and by plasma and urinary norepinephrine levels, respectively. Renal injury was not apparent in young SHRSP compared with WKY, suggesting that renal afferent input might not be activated in young SHRSP. In conclusion, the chronic input from afferent renal nerves does not contribute to the development of hypertension in SHRSP despite the increased blood pressure response to the acute stimulation of afferent renal nerves. Efferent renal nerves may be involved in the development of hypertension via activation of the renin-angiotensin system in SHRSP.
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The anti-hypertensive effects of afferent renal denervation are not universal; Dahl salt-sensitive rats and stroke-prone spontaneously hypertensive rats do not respond to afferent renal denervation but do respond to total renal denervation.
“The anti-hypertensive effects of ARDN are not ubiquitous and several models such as the Dahl salt-sensitive rat77 and the stroke-prone spontaneously hypertensive rat78 do not respond to this intervention but do show anti-hypertensive responses to TRDN77,78.”
From Renal nerves in physiology, pathophysiology and interoception (2025) · cites this paper as [78]
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Research works printed but not linked: 1
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Renal nerves in physiology, pathophysiology and interoception
Evans, L. C., Dayton, A., & Osborn, J. W. (2025) · Nature Reviews Nephrology · doi:10.1038/s41581-024-00893-3 · Cited by 46 · see citing works
- Authors
- Ikeda, S., Shinohara, K., Kashihara, S., Matsumoto, S., Yoshida, D., Nakashima, R., Ono, Y., Nishihara, M., Katsurada, K., & Tsutsui, H.
- Affiliations
- Kyushu University (JP)
- Jichi Medical University (JP)
- Corresponding author
- Shinohara, Keisuke
- ORCID
- Venue
- Hypertension Research
- Published
- 2022-11-11
- Volume
- 46
- Issue
- 1
- Pages
- 268-279
- ISSN
- 0916-9636 (ISSN-L)
- 1348-4214
- OpenAlex
- W4308834913
- Cited by
- 20
- References
- 43
- Citations by year
- 2026: 4 · 2025: 1 · 2024: 12 · 2023: 3
- FWCI
- 2.78
- Type
- journal article
- Language
- en
- Open access
- green
- hdl.handle.net
- Licence
- Locations
- Hypertension Research (publishedVersion)
- PubMed (publishedVersion)
- Kyushu University Institutional Repository (QIR) (Kyushu University) (submittedVersion, other-oa)
- Funders
- Pfizer
- AstraZeneca
- Kowa Company
- Boehringer Ingelheim Japan
- Otsuka Pharmaceutical
- Teijin Pharma
- Mitsubishi Tanabe Pharma Corporation
- Ono Pharmaceutical
- Novartis Pharma
- Pfizer Japan
- Bayer Yakuhin
- Japan Society for the Promotion of Science (21K16094, 21K08032)
- Daiichi Sankyo Europe
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Renin-Angiotensin System Studies
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
- Keywords
- renal afferent nerves, renal denervation, stroke-prone spontaneously hypertensive rats, hypertension, blood pressure regulation, renal sympathetic nerve activity, renin-angiotensin system, plasma renin activity, angiotensin II, central sympathetic outflow, paraventricular nucleus, rostral ventrolateral medulla, norepinephrine, kidney injury
- MeSH terms
- Animals, Blood Pressure, Hypertension, Kidney, Muscle Proteins, Rats, Inbred SHR, Rats, Inbred WKY, Sympathetic Nervous System, Stroke, Intracellular Signaling Peptides and Proteins, Rats
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