The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Photosynthesis-dependent H2O2 transfer from chloroplasts to nuclei provides a high-light signalling mechanism
Open accessAbstract
Chloroplasts communicate information by signalling to nuclei during acclimation to fluctuating light. Several potential operating signals originating from chloroplasts have been proposed, but none have been shown to move to nuclei to modulate gene expression. One proposed signal is hydrogen peroxide (H 2 O 2 ) produced by chloroplasts in a light-dependent manner. Using HyPer2, a genetically encoded fluorescent H 2 O 2 sensor, we show that in photosynthetic Nicotiana benthamiana epidermal cells, exposure to high light increases H 2 O 2 production in chloroplast stroma, cytosol and nuclei. Critically, over-expression of stromal ascorbate peroxidase (H 2 O 2 scavenger) or treatment with DCMU (photosynthesis inhibitor) attenuates nuclear H 2 O 2 accumulation and high light-responsive gene expression. Cytosolic ascorbate peroxidase over-expression has little effect on nuclear H 2 O 2 accumulation and high light-responsive gene expression. This is because the H 2 O 2 derives from a sub-population of chloroplasts closely associated with nuclei. Therefore, direct H 2 O 2 transfer from chloroplasts to nuclei, avoiding the cytosol, enables photosynthetic control over gene expression.
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Suetsugu, N., Higa, T., Gotoh, E., & Wada, M. (2016) · PLOS ONE · doi:10.1371/journal.pone.0157429 · Cited by 44
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Hydrogen peroxide metabolism and functions in plants
Smirnoff, N., & Arnaud, D. (2019) · New Phytologist · doi:10.1111/nph.15488 · Cited by 985
Self-citationReactive oxygen species, oxidative signaling and the regulation of photosynthesis
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Smirnoff, N. (2018) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2018.03.033 · Cited by 667
Self-citationWang, P., Liu, W., Han, C., Wang, S., Bai, M., & Song, C. (2024) · Journal of Integrative Plant Biology · doi:10.1111/jipb.13601 · Cited by 559
Metadata
- Authors
- Exposito-Rodriguez, M., Laissue, P. P., Yvon-Durocher, G., Smirnoff, N., & Mullineaux, P. M.
- Venue
- Nature Communications
- Published
- 2017-06-29
- Volume
- 8
- Issue
- 1
- Pages
- 49-49
- ISSN
- 2041-1723 (ISSN-L)
- OpenAlex
- W2714032413
- Cited by
- 380
- References
- 1
- FWCI
- 12.71
- Type
- journal article
- Language
- en
- Open access
- gold
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- Exposito-Rodriguez, M., Laissue, P. P., Yvon-Durocher, G., Smirnoff, N., & Mullineaux, P. M. (2017). Photosynthesis-dependent H2O2 transfer from chloroplasts to nuclei provides a high-light signalling mechanism. Nature Communications. https://doi.org/10.1038/s41467-017-00074-w
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