The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Landscape of submitochondrial protein distribution
Open accessAbstract
The mitochondrial proteome comprises ~1000 (yeast)–1500 (human) different proteins, which are distributed into four different subcompartments. The sublocalization of these proteins within the organelle in most cases remains poorly defined. Here we describe an integrated approach combining stable isotope labeling, various protein enrichment and extraction strategies and quantitative mass spectrometry to produce a quantitative map of submitochondrial protein distribution in S. cerevisiae. This quantitative landscape enables a proteome-wide classification of 986 proteins into soluble, peripheral, and integral mitochondrial membrane proteins, and the assignment of 818 proteins into the four subcompartments: outer membrane, inner membrane, intermembrane space, or matrix. We also identified 206 proteins that were not previously annotated as localized to mitochondria. Furthermore, the protease Prd1, misannotated as intermembrane space protein, could be re-assigned and characterized as a presequence peptide degrading enzyme in the matrix.
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Cox, J., & Mann, M. (2008) · Nature Biotechnology · doi:10.1038/nbt.1511 · Cited by 14,855
Mass-spectrometric exploration of proteome structure and function
Aebersold, R., & Mann, M. (2016) · Nature · doi:10.1038/nature19949 · Cited by 2,334
Mitochondrial protein import: from proteomics to functional mechanisms
Schmidt, O., Pfanner, N., & Meisinger, C. (2010) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2959 · Cited by 717
Self-citationHung, V., Zou, P., Rhee, H.-W., Udeshi, N. D., Cracan, V., Svinkina, T., Carr, S. A., Mootha, V. K., & Ting, A. Y. (2014) · Molecular Cell · doi:10.1016/j.molcel.2014.06.003 · Cited by 517
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Pfanner, N., Warscheid, B., & Wiedemann, N. (2019) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-018-0092-0 · Cited by 1,028
Mitochondria at the crossroads of health and disease
Suomalainen, A., & Nunnari, J. (2024) · Cell · doi:10.1016/j.cell.2024.04.037 · Cited by 478
Quality control of the mitochondrion
Ng, M. Y. W., Wai, T., & Simonsen, A. (2021) · Developmental Cell · doi:10.1016/j.devcel.2021.02.009 · Cited by 445
Abuaita, B. H., Schultz, T. L., & O’Riordan, M. X. (2018) · Cell Host & Microbe · doi:10.1016/j.chom.2018.10.005 · Cited by 223
An integrative modelling approach to the mitochondrial cristae
(2025) · doi:10.1038/s42003-025-08381-5 · Cited by 21
Metadata
- Authors
- Vögtle, F.-N., Burkhart, J. M., Gonczarowska-Jorge, H., Kücükköse, C., Taskin, A. A., Kopczynski, D., Ahrends, R., Mossmann, D., Sickmann, A., Zahedi, R. P., & Meisinger, C.
- Venue
- Nature Communications
- Published
- 2017-08-18
- Volume
- 8
- Issue
- 1
- Pages
- 290-290
- ISSN
- 2041-1723 (ISSN-L)
- OpenAlex
- W2743319478
- Cited by
- 185
- References
- 4
- FWCI
- 7.80
- Type
- journal article
- Language
- en
- Open access
- gold
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- Vögtle, F.-N., Burkhart, J. M., Gonczarowska-Jorge, H., Kücükköse, C., Taskin, A. A., Kopczynski, D., Ahrends, R., Mossmann, D., Sickmann, A., Zahedi, R. P., & Meisinger, C. (2017). Landscape of submitochondrial protein distribution. Nature Communications. https://doi.org/10.1038/s41467-017-00359-0
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