The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Polarized actin and VE-cadherin dynamics regulate junctional remodelling and cell migration during sprouting angiogenesis
Open accessAbstract
VEGFR-2/Notch signalling regulates angiogenesis in part by driving the remodelling of endothelial cell junctions and by inducing cell migration. Here, we show that VEGF-induced polarized cell elongation increases cell perimeter and decreases the relative VE-cadherin concentration at junctions, triggering polarized formation of actin-driven junction-associated intermittent lamellipodia (JAIL) under control of the WASP/WAVE/ARP2/3 complex. JAIL allow formation of new VE-cadherin adhesion sites that are critical for cell migration and monolayer integrity. Whereas at the leading edge of the cell, large JAIL drive cell migration with supportive contraction, lateral junctions show small JAIL that allow relative cell movement. VEGFR-2 activation initiates cell elongation through dephosphorylation of junctional myosin light chain II, which leads to a local loss of tension to induce JAIL-mediated junctional remodelling. These events require both microtubules and polarized Rac activity. Together, we propose a model where polarized JAIL formation drives directed cell migration and junctional remodelling during sprouting angiogenesis.
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Cites
VEGF guides angiogenic sprouting utilizing endothelial tip cell filopodia
Gerhardt, H., Golding, M., Fruttiger, M., Ruhrberg, C., Lundkvist, A., Abramsson, A., Jeltsch, M., Mitchell, C., Alitalo, K., Shima, D., et al. (2003) · The Journal of Cell Biology · doi:10.1083/jcb.200302047 · Cited by 2,894
Integrin β1 controls VE-cadherin localization and blood vessel stability
Yamamoto, H., Ehling, M., Kato, K., Kanai, K., van Lessen, M., Frye, M., Zeuschner, D., Nakayama, M., Vestweber, D., & Adams, R. H. (2015) · Nature Communications · doi:10.1038/ncomms7429 · Cited by 229
Self-citation
Cited by
Passing the Vascular Barrier: Endothelial Signaling Processes Controlling Extravasation
Wettschureck, N., Strilic, B., & Offermanns, S. (2019) · Physiological Reviews · doi:10.1152/physrev.00037.2018 · Cited by 286
Vion, A.-C., Perovic, T., Petit, C., Hollfinger, I., Bartels-Klein, E., Frampton, E., Gordon, E., Claesson-Welsh, L., & Gerhardt, H. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2020.623769 · Cited by 103
Matrix stiffness modulates tip cell formation through the p-PXN-Rac1-YAP signaling axis
Guo, Y., Mei, F., Huang, Y., Ma, S., Wei, Y., Zhang, X., Xu, M., He, Y., Heng, B. C., Chen, L., et al. (2022) · Bioactive Materials · doi:10.1016/j.bioactmat.2021.05.033 · Cited by 74
Chau, T. C. Y., Keyser, M. S., Da Silva, J. A., Morris, E. K., Yordanov, T. E., Duscyz, K. P., Paterson, S., Yap, A. S., Hogan, B. M., & Lagendijk, A. K. (2022) · Development · doi:10.1242/dev.200454 · Cited by 18
Metadata
- Authors
- Cao, J., Ehling, M., März, S., Seebach, J., Tarbashevich, K., Sixta, T., Pitulescu, M. E., Werner, A.-C., Flach, B., Montanez, E., Raz, E., Adams, R. H., & Schnittler, H.
- Venue
- Nature Communications
- Published
- 2017-12-20
- Volume
- 8
- Issue
- 1
- Pages
- 2210-2210
- ISSN
- 2041-1723 (ISSN-L)
- OpenAlex
- W2771811810
- Cited by
- 173
- References
- 2
- FWCI
- 5.05
- Type
- journal article
- Language
- en
- Open access
- gold
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- CoChat. (2026). Citation check: Polarized actin and VE-cadherin dynamics regulate junctional remodelling and cell migration during sprouting angiogenesis. https://app.cochat.ai/papers/10.1038/s41467-017-02373-8
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- Cao, J., Ehling, M., März, S., Seebach, J., Tarbashevich, K., Sixta, T., Pitulescu, M. E., Werner, A.-C., Flach, B., Montanez, E., Raz, E., Adams, R. H., & Schnittler, H. (2017). Polarized actin and VE-cadherin dynamics regulate junctional remodelling and cell migration during sprouting angiogenesis. Nature Communications. https://doi.org/10.1038/s41467-017-02373-8
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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