VEGF guides angiogenic sprouting utilizing endothelial tip cell filopodia
Open accessAbstract
Vascular endothelial growth factor (VEGF-A) is a major regulator of blood vessel formation and function. It controls several processes in endothelial cells, such as proliferation, survival, and migration, but it is not known how these are coordinately regulated to result in more complex morphogenetic events, such as tubular sprouting, fusion, and network formation. We show here that VEGF-A controls angiogenic sprouting in the early postnatal retina by guiding filopodial extension from specialized endothelial cells situated at the tips of the vascular sprouts. The tip cells respond to VEGF-A only by guided migration; the proliferative response to VEGF-A occurs in the sprout stalks. These two cellular responses are both mediated by agonistic activity of VEGF-A on VEGF receptor 2. Whereas tip cell migration depends on a gradient of VEGF-A, proliferation is regulated by its concentration. Thus, vessel patterning during retinal angiogenesis depends on the balance between two different qualities of the extracellular VEGF-A distribution, which regulate distinct cellular responses in defined populations of endothelial cells.
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VEGF is a major regulator of sprouting angiogenesis.
“VEGF is a major regulator of sprouting angiogenesis (42).”
From The ominous triad of adipose tissue dysfunction: inflammation, fibrosis, and impaired angiogenesis. (2017) · cites this paper as [42]
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Blood Vessel-Targeted Therapy in Colorectal Cancer: Current Strategies and Future Perspectives
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- Authors
- Gerhardt, H., Golding, M., Fruttiger, M., Ruhrberg, C., Lundkvist, A., Abramsson, A., Jeltsch, M., Mitchell, C., Alitalo, K., Shima, D., & Betsholtz, C.
- Affiliations
- University of Gothenburg (SE)
- 2Endothelial Cell Biology Laboratory, Imperial Cancer Research Fund, London WC2A 3PX, UK
- University College London (GB)
- Ludwig Cancer Research (BE)
- University of Nottingham (GB)
- Corresponding author
- Betsholtz, Christer
- ORCID
- Venue
- The Journal of Cell Biology
- Publisher
- Rockefeller University Press
- Published
- 2003-06-16
- Volume
- 161
- Issue
- 6
- Pages
- 1163-1177
- ISSN
- 0021-9525 (ISSN-L)
- 1540-8140
- PMC
- PMC2172999
- OpenAlex
- W2112251383
- Cited by
- 2,894
- References
- 45
- Citations by year
- 2026: 76 · 2025: 91 · 2024: 145 · 2023: 111 · 2022: 147 · 2021: 154 · 2020: 168 · 2019: 172 · 2018: 134 · 2017: 148 · 2016: 142 · 2015: 161 · 2014: 146 · 2013: 145 · 2012: 171
- FWCI
- 19.00
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The Journal of Cell Biology (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion, cc-by-nc-sa)
- PubMed (publishedVersion)
- MDC Repository (Max-Delbrueck-Center for Molecular Medicine) (submittedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Funders
- Swedish Cancer Foundation
- Novo Nordisk
- Novo Nordisk Fonden
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Axon Guidance and Neuronal Signaling
- Health Sciences › Medicine › Oncology › Lymphatic System and Diseases
- Keywords
- VEGF-A, angiogenic sprouting, endothelial tip cells, filopodia, VEGF receptor 2, endothelial cell proliferation, retinal angiogenesis, postnatal retina
- MeSH terms
- Animals, Animals, Newborn, Astrocytes, Cell Differentiation, Cell Division, Cells, Cultured, Dose-Response Relationship, Drug, Endothelium, Vascular, Organ Culture Techniques, Pseudopodia, Retina, Retinal Artery, Endothelial Growth Factors, Mice, Knockout, Neovascularization, Physiologic, Vascular Endothelial Growth Factor Receptor-2, Vascular Endothelial Growth Factor A, Mice
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