The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Identification of single amino acid differences in uniformly charged homopolymeric peptides with aerolysin nanopore
Open accessAbstract
There are still unmet needs in finding new technologies for biomedical diagnostic and industrial applications. A technology allowing the analysis of size and sequence of short peptide molecules of only few molecular copies is still challenging. The fast, low-cost and label-free single-molecule nanopore technology could be an alternative for addressing these critical issues. Here, we demonstrate that the wild-type aerolysin nanopore enables the size-discrimination of several short uniformly charged homopeptides, mixed in solution, with a single amino acid resolution. Our system is very sensitive, allowing detecting and characterizing a few dozens of peptide impurities in a high purity commercial peptide sample, while conventional analysis techniques fail to do so.
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Citations
Cites
Digitally encoded DNA nanostructures for multiplexed, single-molecule protein sensing with nanopores
Bell, N. A. W., & Keyser, U. F. (2016) · Nature Nanotechnology · doi:10.1038/nnano.2016.50 · Cited by 345
Cited by
Nanopore-based technologies beyond DNA sequencing
Ying, Y.-L., Hu, Z.-L., Zhang, S., Qing, Y., Fragasso, A., Maglia, G., Meller, A., Bayley, H., Dekker, C., & Long, Y.-T. (2022) · Nature Nanotechnology · doi:10.1038/s41565-022-01193-2 · Cited by 538
Electrical recognition of the twenty proteinogenic amino acids using an aerolysin nanopore
Ouldali, H., Sarthak, K., Ensslen, T., Piguet, F., Manivet, P., Pelta, J., Behrends, J. C., Aksimentiev, A., & Oukhaled, A. (2020) · Nature Biotechnology · doi:10.1038/s41587-019-0345-2 · Cited by 474
Self-citationSingle-molecule protein sensing in a nanopore: a tutorial
Varongchayakul, N., Song, J., Meller, A., & Grinstaff, M. W. (2018) · Chemical Society Reviews · doi:10.1039/c8cs00106e · Cited by 282
Aerolysin nanopores decode digital information stored in tailored macromolecular analytes
Cao, C., Krapp, L. F., Al Ouahabi, A., König, N. F., Cirauqui, N., Radenovic, A., Lutz, J.-F., & Peraro, M. D. (2020) · Science Advances · doi:10.1126/sciadv.abc2661 · Cited by 97
(2021) · doi:10.1016/j.isci.2021.103202 · Cited by 16
Metadata
- Authors
- Piguet, F., Ouldali, H., Pastoriza-Gallego, M., Manivet, P., Pelta, J., & Oukhaled, A.
- Venue
- Nature Communications
- Published
- 2018-03-06
- Volume
- 9
- Issue
- 1
- Pages
- 966-966
- ISSN
- 2041-1723 (ISSN-L)
- OpenAlex
- W2807505914
- Cited by
- 268
- References
- 1
- FWCI
- 12.84
- Type
- journal article
- Language
- en
- Open access
- gold
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- Piguet, F., Ouldali, H., Pastoriza-Gallego, M., Manivet, P., Pelta, J., & Oukhaled, A. (2018). Identification of single amino acid differences in uniformly charged homopolymeric peptides with aerolysin nanopore. Nature Communications. https://doi.org/10.1038/s41467-018-03418-2
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