The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
The LINC01138 drives malignancies via activating arginine methyltransferase 5 in hepatocellular carcinoma
Open accessAbstract
Recurrent chromosomal aberrations have led to the discovery of oncogenes or tumour suppressors involved in carcinogenesis. Here we characterized an oncogenic long intergenic non-coding RNA in the frequent DNA-gain regions in hepatocellular carcinoma (HCC), LINC01138 (long intergenic non-coding RNA located on 1q21.2). The LINC01138 locus is frequently amplified in HCC; the LINC01138 transcript is stabilized by insulin like growth factor-2 mRNA-binding proteins 1/3 (IGF2BP1/IGF2BP3) and is associated with the malignant features and poor outcomes of HCC patients. LINC01138 acts as an oncogenic driver that promotes cell proliferation, tumorigenicity, tumour invasion and metastasis by physically interacting with arginine methyltransferase 5 (PRMT5) and enhancing its protein stability by blocking ubiquitin/proteasome-dependent degradation in HCC. The discovery of LINC01138, a promising prognostic indicator, provides insight into the molecular pathogenesis of HCC, and the LINC01138/PRMT5 axis is an ideal therapeutic target for HCC treatment.
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Repurposing CRISPR as an RNA-Guided Platform for Sequence-Specific Control of Gene Expression
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A selective inhibitor of PRMT5 with in vivo and in vitro potency in MCL models
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Yan, H., & Bu, P. (2021) · Essays in Biochemistry · doi:10.1042/ebc20200032 · Cited by 667
LncRNA LINRIS stabilizes IGF2BP2 and promotes the aerobic glycolysis in colorectal cancer
Wang, Y., Lu, J.-H., Wu, Q.-N., Jin, Y., Wang, D.-S., Chen, Y.-X., Liu, J., Luo, X.-J., Meng, Q., Pu, H.-Y., et al. (2019) · Molecular Cancer · doi:10.1186/s12943-019-1105-0 · Cited by 507
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Self-citation
Metadata
- Authors
- Li, Z., Zhang, J., Liu, X., Li, S., Wang, Q., Chen, D., Hu, Z., Yu, T., Ding, J., Li, J., Yao, M., Fan, J., Huang, S., Gao, Q., Zhao, Y., & He, X.
- Venue
- Nature Communications
- Published
- 2018-04-20
- Volume
- 9
- Issue
- 1
- Pages
- 1572-1572
- ISSN
- 2041-1723 (ISSN-L)
- OpenAlex
- W2799792816
- Cited by
- 217
- References
- 8
- FWCI
- 7.52
- Type
- journal article
- Language
- en
- Status
- Retracted
- Open access
- gold
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- Li, Z., Zhang, J., Liu, X., Li, S., Wang, Q., Chen, D., Hu, Z., Yu, T., Ding, J., Li, J., Yao, M., Fan, J., Huang, S., Gao, Q., Zhao, Y., & He, X. (2018). The LINC01138 drives malignancies via activating arginine methyltransferase 5 in hepatocellular carcinoma. Nature Communications. https://doi.org/10.1038/s41467-018-04006-0
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