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High spatial resolution nanoslit SERS for single-molecule nucleobase sensing
Open accessAbstract
Solid-state nanopores promise a scalable platform for single-molecule DNA analysis. Direct, real-time identification of nucleobases in DNA strands is still limited by the sensitivity and the spatial resolution of established ionic sensing strategies. Here, we study a different but promising strategy based on optical spectroscopy. We use an optically engineered elongated nanopore structure, a plasmonic nanoslit, to locally enable single-molecule surface enhanced Raman spectroscopy (SERS). Combining SERS with nanopore fluidics facilitates both the electrokinetic capture of DNA analytes and their local identification through direct Raman spectroscopic fingerprinting of four nucleobases. By studying the stochastic fluctuation process of DNA analytes that are temporarily adsorbed inside the pores, we have observed asynchronous spectroscopic behavior of different nucleobases, both individual and incorporated in DNA strands. These results provide evidences for the single-molecule sensitivity and the sub-nanometer spatial resolution of plasmonic nanoslit SERS.
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Cites
Coming of age: ten years of next-generation sequencing technologies
Goodwin, S., McPherson, J. D., & McCombie, W. R. (2016) · Nature Reviews Genetics · doi:10.1038/nrg.2016.49 · Cited by 4,352
Coherent Raman spectro-imaging with laser frequency combs
Ideguchi, T., Holzner, S., Bernhardt, B., Guelachvili, G., Picqué, N., & Hänsch, T. W. (2013) · Nature · doi:10.1038/nature12607 · Cited by 475
Cited by
Surface-enhanced Raman spectroscopy: benefits, trade-offs and future developments
Pérez-Jiménez, A. I., Lyu, D., Lu, Z., Liu, G., & Ren, B. (2020) · Chemical Science · doi:10.1039/d0sc00809e · Cited by 912
Surface-enhanced Raman spectroscopy
Han, X. X., Rodriguez, R. S., Haynes, C. L., Ozaki, Y., & Zhao, B. (2022) · Nature Reviews Methods Primers · doi:10.1038/s43586-021-00083-6 · Cited by 907
Fundamental understanding and applications of plasmon-enhanced Raman spectroscopy
Wang, X., Huang, S.-C., Hu, S., Yan, S., & Ren, B. (2020) · Nature Reviews Physics · doi:10.1038/s42254-020-0171-y · Cited by 689
From molecular to supramolecular electronics
Chen, H., & Fraser Stoddart, J. (2021) · Nature Reviews Materials · doi:10.1038/s41578-021-00302-2 · Cited by 380
Surface-Enhanced Raman Spectroscopy: Current Understanding, Challenges, and Opportunities
Ma, H., Pan, S.-Q., Wang, W.-L., Yue, X., Xi, X.-H., Yan, S., Wu, D.-Y., Wang, X., Liu, G., & Ren, B. (2024) · ACS Nano · doi:10.1021/acsnano.4c02670 · Cited by 346
Metadata
- Authors
- Chen, C., Li, Y., Kerman, S., Neutens, P., Willems, K., Cornelissen, S., Lagae, L., Stakenborg, T., & Van Dorpe, P.
- Venue
- Nature Communications
- Published
- 2018-04-30
- Volume
- 9
- Issue
- 1
- Pages
- 1733-1733
- ISSN
- 2041-1723 (ISSN-L)
- OpenAlex
- W2799560078
- Cited by
- 202
- References
- 2
- FWCI
- 8.12
- Type
- journal article
- Language
- en
- Open access
- gold
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- Chen, C., Li, Y., Kerman, S., Neutens, P., Willems, K., Cornelissen, S., Lagae, L., Stakenborg, T., & Van Dorpe, P. (2018). High spatial resolution nanoslit SERS for single-molecule nucleobase sensing. Nature Communications. https://doi.org/10.1038/s41467-018-04118-7
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