Coherent Raman spectro-imaging with laser frequency combs
Open accessAbstract
Advances in optical spectroscopy and microscopy have had a profound impact throughout the physical, chemical and biological sciences. One example is coherent Raman spectroscopy, a versatile technique interrogating vibrational transitions in molecules. It offers high spatial resolution and three-dimensional sectioning capabilities that make it a label-free tool for the non-destructive and chemically selective probing of complex systems. Indeed, single-colour Raman bands have been imaged in biological tissue at video rates by using ultra-short-pulse lasers. However, identifying multiple, and possibly unknown, molecules requires broad spectral bandwidth and high resolution. Moderate spectral spans combined with high-speed acquisition are now within reach using multichannel detection or frequency-swept laser beams. Laser frequency combs are finding increasing use for broadband molecular linear absorption spectroscopy. Here we show, by exploring their potential for nonlinear spectroscopy, that they can be harnessed for coherent anti-Stokes Raman spectroscopy and spectro-imaging. The method uses two combs and can simultaneously measure, on the microsecond timescale, all spectral elements over a wide bandwidth and with high resolution on a single photodetector. Although the overall measurement time in our proof-of-principle experiments is limited by the waiting times between successive spectral acquisitions, this limitation can be overcome with further system development. We therefore expect that our approach of using laser frequency combs will not only enable new applications for nonlinear microscopy but also benefit other nonlinear spectroscopic techniques.
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Cites
Principles of Nonlinear Optical Spectroscopy
Mukamel, S. (1995) · Cited by 4,566 · see citing works
Microresonator-Based Optical Frequency Combs
Kippenberg, T. J., Holzwarth, R., & Diddams, S. A. (2011) · Science · doi:10.1126/science.1193968 · Cited by 2,159 · see citing works
Schließer, A., Picqué, N., & Hänsch, T. W. (2012) · Nature Photonics · doi:10.1038/nphoton.2012.142 · Cited by 1,435 · see citing works
Self-citationEvans, C. L., Potma, E. O., Puoris'haag, M., Côté, D., Lin, C. P., & Xie, X. S. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0508282102 · Cited by 957 · see citing works
Nobel Lecture: Passion for precision
Hänsch, T. W. (2006) · Reviews of Modern Physics · doi:10.1103/revmodphys.78.1297 · Cited by 914 · see citing works
Self-citationVideo-Rate Molecular Imaging in Vivo with Stimulated Raman Scattering
Saar, B. G., Freudiger, C. W., Reichman, J. R., Stanley, C. M., Holtom, G. R., & Xie, X. S. (2010) · Science · doi:10.1126/science.1197236 · Cited by 846 · see citing works
Coherent Multiheterodyne Spectroscopy Using Stabilized Optical Frequency Combs
Coddington, I. R., Swann, W. C., & Newbury, N. R. (2008) · Physical Review Letters · doi:10.1103/physrevlett.100.013902 · Cited by 821 · see citing works
Molecular fingerprinting with the resolved modes of a femtosecond laser frequency comb
Diddams, S. A., Hollberg, L. W., & Mbele, V. (2007) · Nature · doi:10.1038/nature05524 · Cited by 808 · see citing works
Serial time-encoded amplified imaging for real-time observation of fast dynamic phenomena
Goda, K., Tsia, K., & Jalali, B. (2009) · Nature · doi:10.1038/nature07980 · Cited by 753 · see citing works
Single-pulse coherently controlled nonlinear Raman spectroscopy and microscopy
Dudovich, N., Oron, D., & Silberberg, Y. R. (2002) · Nature · doi:10.1038/nature00933 · Cited by 732 · see citing works
Coherent Nonlinear Optical Imaging: Beyond Fluorescence Microscopy
Min, W., Freudiger, C. W., Lü, S., & Xie, X. S. (2011) · Annual Review of Physical Chemistry · doi:10.1146/annurev.physchem.012809.103512 · Cited by 606 · see citing works
Yan, Y.-X., Gamble, E. B., & Nelson, K. A. (1985) · The Journal of Chemical Physics · doi:10.1063/1.449708 · Cited by 605 · see citing works
Cavity-enhanced dual-comb spectroscopy
Bernhardt, B., Ozawa, A., Jacquet, P., Jacquey, M., Kobayashi, Y., Udem, T., Holzwarth, R., Guelachvili, G., Hänsch, T. W., & Picqué, N. (2009) · Nature Photonics · doi:10.1038/nphoton.2009.217 · Cited by 589 · see citing works
Self-citationHigh-speed molecular spectral imaging of tissue with stimulated Raman scattering
Ozeki, Y., Umemura, W., Otsuka, Y., Satoh, S., Hashimoto, H., Sumimura, K., Nishizawa, N., Fukui, K., & Itoh, K. (2012) · Nature Photonics · doi:10.1038/nphoton.2012.263 · Cited by 519 · see citing works
Broadband Cavity Ringdown Spectroscopy for Sensitive and Rapid Molecular Detection
Thorpe, M. J., Moll, K. D., Jones, R. J., Safdi, B. R., & Ye, J. (2006) · Science · doi:10.1126/science.1123921 · Cited by 510 · see citing works
Tip-Enhanced Coherent Anti-Stokes Raman Scattering for Vibrational Nanoimaging
Ichimura, T., Hayazawa, N., Hashimoto, M., Inouye, Y., & Kawata, S. (2004) · Physical Review Letters · doi:10.1103/physrevlett.92.220801 · Cited by 405 · see citing works
Polarization coherent anti-Stokes Raman scattering microscopy
Cheng, J., Book, L. D., & Xie, X. S. (2001) · Optics Letters · doi:10.1364/ol.26.001341 · Cited by 402 · see citing works
Hyperspectral Imaging with Stimulated Raman Scattering by Chirped Femtosecond Lasers
Fu, D., Holtom, G., Freudiger, C. W., Zhang, X., & Xie, X. S. (2012) · The Journal of Physical Chemistry B · doi:10.1021/jp308938t · Cited by 323 · see citing works
Volkmer, A., Book, L. D., & Xie, X. S. (2002) · Applied Physics Letters · doi:10.1063/1.1456262 · Cited by 294 · see citing works
10-GHz Self-Referenced Optical Frequency Comb
Bartels, A., Heinecke, D., & Diddams, S. A. (2009) · Science · doi:10.1126/science.1179112 · Cited by 232 · see citing works
Recent Advances in linear and nonlinear Raman spectroscopy I
Kiefer, W. (2007) · Journal of Raman Spectroscopy · doi:10.1002/jrs.1902 · Cited by 214 · see citing works
Optimally chirped multimodal CARS microscopy based on a single Ti:sapphire oscillator
Pegoraro, A. F., Ridsdale, A., Moffatt, D. J., Jia, Y., Pezacki, J. P., & Stolow, A. (2009) · Optics Express · doi:10.1364/oe.17.002984 · Cited by 196 · see citing works
Femtosecond multiple-pulse impulsive stimulated Raman scattering spectroscopy
Weiner, A. M., Wiederrecht, G. P., Nelson, K. A., & Leaird, D. E. (1991) · Journal of the Optical Society of America B · doi:10.1364/josab.8.001264 · Cited by 180 · see citing works
Surface-Enhanced Femtosecond Stimulated Raman Spectroscopy
Frontiera, R. R., Henry, A.-I., Gruenke, N. L., & Duyne, R. P. V. (2011) · The Journal of Physical Chemistry Letters · doi:10.1021/jz200498z · Cited by 159 · see citing works
Fourier-transform coherent anti-Stokes Raman scattering microscopy
Ogilvie, J. P., Beaurepaire, E., Alexandrou, A., & Joffre, M. (2006) · Optics Letters · doi:10.1364/ol.31.000480 · Cited by 140 · see citing works
Surface Enhanced Coherent Anti-Stokes Raman Scattering on Nanostructured Gold Surfaces
Steuwe, C., Kaminski, C. F., Baumberg, J. J., & Mahajan, S. (2011) · Nano Letters · doi:10.1021/nl202875w · Cited by 139 · see citing works
Visualization of silicone gel in human breast tissue using new infrared imaging spectroscopy
Kidder, L. H., KALASINSKY, V. F., Luke, J. L., Levin, I. W., & Lewis, E. N. (1997) · Nature Medicine · doi:10.1038/nm0297-235 · Cited by 120 · see citing works
Xie, X., Zhang, X., Chen, T., Yu, Z., & HUANG, Y. (2012) · Scientia Sinica Chimica · doi:10.1360/032011-609 · Cited by 118 · see citing works
Multicolor stimulated Raman scattering microscopy
Lu, F., Ji, M., Fu, D., Ni, X., Freudiger, C. W., Holtom, G., & Xie, X. S. (2012) · Molecular Physics · doi:10.1080/00268976.2012.695028 · Cited by 112 · see citing works
Kong, L., Ji, M., Holtom, G. R., Fu, D., Freudiger, C. W., & Xie, X. S. (2013) · Optics Letters · doi:10.1364/ol.38.000145 · Cited by 100 · see citing works
Raman-induced Kerr-effect dual-comb spectroscopy
Ideguchi, T., Bernhardt, B., Guelachvili, G., Hänsch, T. W., & Picqué, N. (2012) · Optics Letters · doi:10.1364/ol.37.004498 · Cited by 86 · see citing works
Self-citationRaman-induced Kerr-effect dual-comb spectroscopy
Ideguchi, T., Bernhardt, B., Guelachvili, G., Hänsch, T. W., & Picqué, N. (2012) · MPG.PuRe (Max Planck Society) · Cited by 72 · see citing works
Self-citationKnutsen, K. P., Messer, B. M., Onorato, R. M., & Saykally, R. J. (2006) · The Journal of Physical Chemistry B · doi:10.1021/jp052416a · Cited by 52 · see citing works
Hiramatsu, K., Okuno, M., Kano, H., Leproux, P., Couderc, V., & Hamaguchi, H. (2012) · Physical Review Letters · doi:10.1103/physrevlett.109.083901 · Cited by 52 · see citing works
Generation of 120-fs laser pulses at 1-GHz repetition rate derived from continuous wave laser diode
Ishizawa, A., Nishikawa, T., Mizutori, A., TAKARA, H., Nakano, H., Sogawa, T., Takada, A., & Koga, M. (2011) · Optics Express · doi:10.1364/oe.19.022402 · Cited by 46 · see citing works
Cleff, C., Groß, P., Fallnich, C., Offerhaus, H. L., Herek, J. L., Kruse, K., Beeker, W. P., Lee, C., & Boller, K. J. (2012) · Physical Review A · doi:10.1103/physreva.86.023825 · Cited by 36 · see citing works
Recent advances in linear and nonlinear Raman spectroscopy. Part VI
Nafié, L. A. (2012) · Journal of Raman Spectroscopy · doi:10.1002/jrs.4221 · Cited by 27 · see citing works
Recent advances in linear and nonlinear Raman spectroscopy. Part V
Nafié, L. A. (2011) · Journal of Raman Spectroscopy · doi:10.1002/jrs.3115 · Cited by 21 · see citing works
Flagged first, then by citations
1 of the 39 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Dissipative Kerr solitons in optical microresonators
Kippenberg, T. J., Gaeta, A. L., Lipson, M. F., & Gorodetsky, M. L. (2018) · Science · doi:10.1126/science.aan8083 · Cited by 1,831 · see citing works
Coddington, I., Newbury, N., & Swann, W. (2016) · Optica · doi:10.1364/optica.3.000414 · Cited by 1,754 · see citing works
Picqué, N., & Hänsch, T. W. (2019) · Nature Photonics · doi:10.1038/s41566-018-0347-5 · Cited by 1,259 · see citing works
Self-citation20 years of developments in optical frequency comb technology and applications
Fortier, T., & Baumann, E. (2019) · Communications Physics · doi:10.1038/s42005-019-0249-y · Cited by 964 · see citing works
Photonic chip–based optical frequency comb using soliton Cherenkov radiation
Brasch, V., Geiselmann, M., Herr, T., Lihachev, G., Pfeiffer, M. H. P., Gorodetsky, M. L., & Kippenberg, T. J. (2016) · Science · doi:10.1126/science.aad4811 · Cited by 872 · see citing works
Optical frequency combs: Coherently uniting the electromagnetic spectrum
Diddams, S. A., Vahala, K. J., & Udem, T. (2020) · Science · doi:10.1126/science.aay3676 · Cited by 722 · see citing works
Dual-comb spectroscopy based on quantum-cascade-laser frequency combs
Villares, G., Hugi, A., Blaser, S., & Faist, J. (2014) · Nature Communications · doi:10.1038/ncomms6192 · Cited by 521 · see citing works
Chemically sensitive bioimaging with coherent Raman scattering
Camp Jr, C. H., & Cicerone, M. T. (2015) · Nature Photonics · doi:10.1038/nphoton.2015.60 · Cited by 472 · see citing works
Adaptive real-time dual-comb spectroscopy
Ideguchi, T., Poisson, A., Guelachvili, G., Picqué, N., & Hänsch, T. W. (2014) · Nature Communications · doi:10.1038/ncomms4375 · Cited by 434 · see citing works
Self-citationFrequency-agile dual-comb spectroscopy
Millot, G., Pitois, S., Yan, M., Hovhannisyan, T., Bendahmane, A., Hänsch, T. W., & Picqué, N. (2016) · Nature Photonics · doi:10.1038/nphoton.2015.250 · Cited by 423 · see citing works
Self-citationSilicon-chip-based mid-infrared dual-comb spectroscopy
Yu, M., Okawachi, Y., Griffith, A. G., Picqué, N., Lipson, M. F., & Gaeta, A. L. (2018) · Nature Communications · doi:10.1038/s41467-018-04350-1 · Cited by 417 · see citing works
Self-citationFrequency-comb-based remote sensing of greenhouse gases over kilometer air paths
Rieker, G. B., Giorgetta, F. R., Swann, W. C., Kofler, J. D., Zolot, A. M., Sinclair, L. C., Baumann, E., Cromer, C. L., Pétron, G., Sweeney, C., et al. (2014) · Optica · doi:10.1364/optica.1.000290 · Cited by 413 · see citing works
Raman spectroscopy: techniques and applications in the life sciences
Shipp, D. W., Sinjab, F., & Notingher, I. (2017) · Advances in Optics and Photonics · doi:10.1364/aop.9.000315 · Cited by 398 · see citing works
Parriaux, A., Hammani, K., & Millot, G. (2020) · Advances in Optics and Photonics · doi:10.1364/aop.382052 · Cited by 389 · see citing works
Tao, G., Ebendorff‐Heidepriem, H., Stolyarov, A. M., Danto, S., Badding, J. V., Fink, Y., Ballato, J. M., & Abouraddy, A. F. (2015) · Advances in Optics and Photonics · doi:10.1364/aop.7.000379 · Cited by 348 · see citing works
Octave-spanning dissipative Kerr soliton frequency combs in Si_3N_4 microresonators
Pfeiffer, M. H. P., Herkommer, C., Liu, J., Guo, H., Karpov, M., Lucas, E., Zervas, M., & Kippenberg, T. J. (2017) · Optica · doi:10.1364/optica.4.000684 · Cited by 322 · see citing works
Label-free DNA imaging in vivo with stimulated Raman scattering microscopy
Lu, F., Basu, S., Igras, V., Hoang, M. P., Ji, M., Fu, D., Holtom, G. R., Neel, V., Freudiger, C. W., Fisher, D. E., et al. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1515121112 · Cited by 308 · see citing works
Gate-tunable frequency combs in graphene–nitride microresonators
Yao, B., Huang, S., Liu, Y., Vinod, A. K., Choi, C., Hoff, M. T., Li, Y., Yu, M., Feng, Z., Kwong, D., et al. (2018) · Nature · doi:10.1038/s41586-018-0216-x · Cited by 296 · see citing works
Integrated femtosecond pulse generator on thin-film lithium niobate
Yu, M., Barton, D. R., Cheng, R., Reimer, C., Kharel, P., He, L., Shao, L., Zhu, D., Hu, Y., Grant, H. R., et al. (2022) · Nature · doi:10.1038/s41586-022-05345-1 · Cited by 289 · see citing works
Molecular fingerprinting with bright, broadband infrared frequency combs
Timmers, H. R., Kowligy, A. S., Lind, A. J., Cruz, F. C., Nader, N., Silfies, M., Ycas, G. G., Allison, T. K., Schunemann, P. G., Papp, S. B., et al. (2018) · Optica · doi:10.1364/optica.5.000727 · Cited by 235 · see citing works
Novel Light Source Integration Approaches for Silicon Photonics
Wang, Z., Abbasi, A., Dave, U., De Groote, A., Kumari, S., Kunert, B., Merckling, C., Pantouvaki, M., Shi, Y., Tian, B., et al. (2017) · Laser & Photonics Reviews · doi:10.1002/lpor.201700063 · Cited by 213 · see citing works
Real-time dual-comb spectroscopy with a free-running bidirectionally mode-locked fiber laser
Mehravar, S., Norwood, R. A., Peyghambarian, N. N., & Kieu, K. Q. (2016) · Applied Physics Letters · doi:10.1063/1.4953400 · Cited by 205 · see citing works
High spatial resolution nanoslit SERS for single-molecule nucleobase sensing
Chen, C. Q., Li, Y., Kerman, S., Neutens, P., Willems, K., Cornelissen, S., Lagae, L., Stakenborg, T., & Dorpe, P. V. (2018) · Nature Communications · doi:10.1038/s41467-018-04118-7 · Cited by 202 · see citing works
Krafft, C., Schie, I. W., Meyer, T., Schmitt, M. P., & Popp, J. (2015) · Chemical Society Reviews · doi:10.1039/c5cs00564g · Cited by 199 · see citing works
Kerr-lens mode-locked bidirectional dual-comb ring laser for broadband dual-comb spectroscopy
Ideguchi, T., Nakamura, T., Kobayashi, Y., & Goda, K. (2016) · Optica · doi:10.1364/optica.3.000748 · Cited by 194 · see citing works
Self-citationA III-V-on-Si ultra-dense comb laser
Wang, Z., Gasse, K. V., Moskalenko, V., Latkowski, S., Bente, E. A. J. M., Kuyken, B., & Roelkens, G. (2016) · Light Science & Applications · doi:10.1038/lsa.2016.260 · Cited by 176 · see citing works
Spatial multiplexing of soliton microcombs
Lucas, E., Lihachev, G., Bouchand, R., Pavlov, N. G., Raja, A. S., Karpov, M., Gorodetsky, M. L., & Kippenberg, T. J. (2018) · Nature Photonics · doi:10.1038/s41566-018-0256-7 · Cited by 170 · see citing works
Beha, K., Cole, D. C., Del’Haye, P., Coillet, A., Diddams, S. A., & Papp, S. B. (2017) · Optica · doi:10.1364/optica.4.000406 · Cited by 168 · see citing works
Infrared electric field sampled frequency comb spectroscopy
Kowligy, A. S., Timmers, H. R., Lind, A. J., Elu, U., Cruz, F. C., Schunemann, P. G., Biegert, J., & Diddams, S. A. (2019) · Science Advances · doi:10.1126/sciadv.aaw8794 · Cited by 166 · see citing works
Kowalewski, M., Bennett, K., Dorfman, K. E., & Mukamel, S. (2015) · Physical Review Letters · doi:10.1103/physrevlett.115.193003 · Cited by 165 · see citing works
Broadband Coherent Raman Scattering Microscopy
Polli, D., Kumar, V., Valensise, C. M., Marangoni, M., & Cerullo, G. (2018) · Laser & Photonics Review · doi:10.1002/lpor.201800020 · Cited by 150 · see citing works
Kowalewski, M., Fingerhut, B. P., Dorfman, K. E., Bennett, K., & Mukamel, S. (2017) · Chemical Reviews · doi:10.1021/acs.chemrev.7b00081 · Cited by 143 · see citing works
A six-octave optical frequency comb from a scalable few-cycle erbium fibre laser
Lesko, D., Timmers, H., Xing, S., Kowligy, A., Lind, A. J., & Diddams, S. A. (2021) · Nature Photonics · doi:10.1038/s41566-021-00778-y · Cited by 141 · see citing works
Ferreira, M. F. S., Castro-Camus, E., Ottaway, D. J., Higuera, J. M. L., Feng, X., Jin, W., Jeong, Y., Picqué, N., Tong, L., Reinhard, B. M., et al. (2017) · Journal of Optics · doi:10.1088/2040-8986/aa7419 · Cited by 140 · see citing works
Self-citationA phase-stable dual-comb interferometer
Chen, Z., Yan, M., Hänsch, T. W., & Picqué, N. (2018) · Nature Communications · doi:10.1038/s41467-018-05509-6 · Cited by 139 · see citing works
Self-citationSoliton dual frequency combs in crystalline microresonators
Pavlov, N. G., Lihachev, G., Koptyaev, S., Lucas, E., Karpov, M., Kondratiev, N. M., Bilenko, I. A., Kippenberg, T. J., & Gorodetsky, M. L. (2017) · Optics Letters · doi:10.1364/ol.42.000514 · Cited by 136 · see citing works
Complementary vibrational spectroscopy
Hashimoto, K., Badarla, V. R., Kawai, A., & Ideguchi, T. (2019) · Nature Communications · doi:10.1038/s41467-019-12442-9 · Cited by 138 · see citing works
Self-citationHigh-coherence ultra-broadband bidirectional dual-comb fiber laser
Nakajima, Y., Hata, Y., & Minoshima, K. (2019) · Optics Express · doi:10.1364/oe.27.005931 · Cited by 130 · see citing works
Quartz-enhanced multiheterodyne resonant photoacoustic spectroscopy
Wang, J., Wu, H., Sampaolo, A., Patimisco, P., Spagnolo, V., Jia, S., & Dong, L. (2024) · Light Science & Applications · doi:10.1038/s41377-024-01425-1 · Cited by 125 · see citing works
Silicon carbide for integrated photonics
Yi, A., Wang, C., Zhou, L., Zhu, Y., Zhang, S., You, T., Zhang, J., & Ou, X. (2022) · Applied Physics Reviews · doi:10.1063/5.0079649 · Cited by 124 · see citing works
The time-programmable frequency comb and its use in quantum-limited ranging
Caldwell, E. D., Sinclair, L. C., Newbury, N. R., & Deschênes, J.-D. (2022) · Nature · doi:10.1038/s41586-022-05225-8 · Cited by 121 · see citing works
Liao, C., Wang, P., Wang, P., Li, J., Lee, H. J., Eakins, G. S., & Cheng, J. (2015) · Science Advances · doi:10.1126/sciadv.1500738 · Cited by 109 · see citing works
Bidirectional mode-locked all-normal dispersion fiber laser
Li, B., Xing, J., Kwon, D., Xie, Y., Prakash, N., Kim, J., & Huang, S. (2020) · Optica · doi:10.1364/optica.396304 · Cited by 108 · see citing works
Dual-comb hyperspectral digital holography
Vicentini, E., Wang, Z., Gasse, K. V., Hänsch, T. W., & Picqué, N. (2021) · Nature Photonics · doi:10.1038/s41566-021-00892-x · Cited by 107 · see citing works
Self-citationLi, C., Ma, Y., Gao, X., Niu, F., Jiang, T., Wang, A., & Zhang, Z. (2015) · Applied Optics · doi:10.1364/ao.54.008350 · Cited by 105 · see citing works
Development of ultrafast time-resolved dual-comb spectroscopy
Asahara, A., & Minoshima, K. (2017) · APL Photonics · doi:10.1063/1.4976730 · Cited by 103 · see citing works
Complementary vibrational spectroscopy
Hashimoto, K., Badarla, V. R., Kawai, A., & Ideguchi, T. (2019) · RePEc: Research Papers in Economics · Cited by 104 · see citing works
Self-citationCavity-enhanced photoacoustic dual-comb spectroscopy
Wang, Z., Nie, Q., Sun, H., Wang, Q., Borri, S., Natale, P. D., & Ren, W. (2024) · Light Science & Applications · doi:10.1038/s41377-023-01353-6 · Cited by 106 · see citing works
A Time-Encoded Technique for fibre-based hyperspectral broadband stimulated Raman microscopy
Karpf, S., Eibl, M., Wieser, W., Klein, T., & Huber, R. A. (2015) · Nature Communications · doi:10.1038/ncomms7784 · Cited by 102 · see citing works
Photonic chip-based soliton frequency combs covering the biological imaging window
Karpov, M., Pfeiffer, M. H. P., Liu, J., Lukashchuk, A., & Kippenberg, T. J. (2018) · Nature Communications · doi:10.1038/s41467-018-03471-x · Cited by 100 · see citing works
Dual chirped microcomb based parallel ranging at megapixel-line rates
Lukashchuk, A., Riemensberger, J., Karpov, M., Liu, J., & Kippenberg, T. J. (2022) · Nature Communications · doi:10.1038/s41467-022-30542-x · Cited by 101 · see citing works
Coherent cavity-enhanced dual-comb spectroscopy
Fleisher, A. J., Long, D. A., Reed, Z., Hodges, J. T., & Plusquellic, D. F. (2016) · Optics Express · doi:10.1364/oe.24.010424 · Cited by 98 · see citing works
Ultrafast electrooptic dual-comb interferometry
Durán, V., Tainta, S., & Torres-Company, V. (2015) · Optics Express · doi:10.1364/oe.23.030557 · Cited by 96 · see citing works
Customizing supercontinuum generation via on-chip adaptive temporal pulse-splitting
Wetzel, B., Kues, M., Roztocki, P., Reimer, C., Godin, P.-L., Rowley, M., Little, B. E., Chu, S. T., Viktorov, E. A., Moss, D., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-07141-w · Cited by 96 · see citing works
Counting the cycles of light using a self-referenced optical microresonator
Jost, J. D., Herr, T., Lecaplain, C., Brasch, V., Pfeiffer, M. H. P., & Kippenberg, T. J. (2015) · Optica · doi:10.1364/optica.2.000706 · Cited by 93 · see citing works
Dual-comb spectroscopic ellipsometry
Minamikawa, T., Hsieh, Y.-D., Shibuya, K., Hase, E., Kaneoka, Y., Okubo, S., Inaba, H., Mizutani, Y., Yamamoto, H., Iwata, T., et al. (2017) · Nature Communications · doi:10.1038/s41467-017-00709-y · Cited by 92 · see citing works
Dual-comb coherent Raman spectroscopy with lasers of 1-GHz pulse repetition frequency
Mohler, K. J., Bohn, B. J., Yan, M., Mélen, G., Hänsch, T. W., & Picqué, N. (2017) · Optics Letters · doi:10.1364/ol.42.000318 · Cited by 92 · see citing works
Self-citationNakajima, Y., Hata, Y., & Minoshima, K. (2019) · Optics Express · doi:10.1364/oe.27.014648 · Cited by 93 · see citing works
A broadband chip-scale optical frequency synthesizer at 2.7 × 10 −16 relative uncertainty
Huang, S., Yang, J., Yu, M., McGuyer, B. H., Kwong, D., Zelevinsky, T., & Wong, C. W. (2016) · Science Advances · doi:10.1126/sciadv.1501489 · Cited by 88 · see citing works
Dual-comb spectroscopy for rapid characterization of complex optical properties of solids
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Piccardo, M., Ginis, V., Forbes, A., Mahler, S., Friesem, A. A., Davidson, N., Ren, H., Dorrah, A. H., Capasso, F., Dullo, F. T., et al. (2021) · Journal of Optics · doi:10.1088/2040-8986/ac3a9d · Cited by 86 · see citing works
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Yang, J. S., Gasse, K. V., Lukin, D. M., Guidry, M. A., Ahn, G. H., White, A. D., & Jelena Vuckovic, A. (2024) · Nature · doi:10.1038/s41586-024-07457-2 · Cited by 84 · see citing works
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Yang, Q., Hu, Y., & Vahala, K. J. (2024) · eLight · doi:10.1186/s43593-024-00075-5 · Cited by 85 · see citing works
Broadband coherent Raman spectroscopy running at 24,000 spectra per second
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Mayer, A. S., Phillips, C. R., & Keller, U. (2017) · Nature Communications · doi:10.1038/s41467-017-01999-y · Cited by 79 · see citing works
Hu, D., Wu, Z., Cao, H., Shi, Y., Li, R., Tian, H., Song, Y., & Hu, M. (2020) · Optics Communications · doi:10.1016/j.optcom.2020.126566 · Cited by 77 · see citing works
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Bao, Y., Yi, X., Li, Z., Chen, Q., Li, J., Fan, X., & Zhang, X. (2015) · Light Science & Applications · doi:10.1038/lsa.2015.73 · Cited by 67 · see citing works
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Scan-less hyperspectral dual-comb single-pixel-imaging in both amplitude and phase
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Yu, H., Ni, K., Zhou, Q., Li, X., Wang, X., & Wu, G. (2019) · Optics Express · doi:10.1364/oe.27.029425 · Cited by 63 · see citing works
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Tamamitsu, M., Sakaki, Y., Nakamura, T., Podagatlapalli, G. K., Ideguchi, T., & Goda, K. (2016) · Vibrational Spectroscopy · doi:10.1016/j.vibspec.2016.07.007 · Cited by 59 · see citing works
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Pozzi, E. A., Sonntag, M. D., Jiang, N., Chiang, N., Seideman, T., Hersam, M. C., & Duyne, R. P. V. (2014) · The Journal of Physical Chemistry Letters · doi:10.1021/jz501239z · Cited by 52 · see citing works
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Jerez, B., Martín‐Mateos, P., Prior, E., de Dios, C., & Acedo, P. (2016) · Optics Express · doi:10.1364/oe.24.014986 · Cited by 54 · see citing works
Nakajima, Y., Kusumi, Y., & Minoshima, K. (2021) · Optics Letters · doi:10.1364/ol.440818 · Cited by 48 · see citing works
In Situ and In Vivo Molecular Analysis by Coherent Raman Scattering Microscopy
Liao, C., & Cheng, J. (2016) · Annual Review of Analytical Chemistry · doi:10.1146/annurev-anchem-071015-041627 · Cited by 48 · see citing works
- Authors
- Ideguchi, T., Holzner, S., Bernhardt, B., Guelachvili, G., Picqué, N., & Hänsch, T. W.
- Affiliations
- Max Planck Institute of Quantum Optics (DE)
- Université Paris-Sud (FR)
- Corresponding author
- Picqué, Nathalie
- Venue
- Nature
- Published
- 2013-10-16
- Volume
- 502
- Issue
- 7471
- Pages
- 355-358
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W2074049639
- Cited by
- 475
- References
- 39
- Citations by year
- 2026: 16 · 2025: 30 · 2024: 38 · 2023: 47 · 2022: 33 · 2021: 35 · 2020: 38 · 2019: 43 · 2018: 44 · 2017: 48 · 2016: 38 · 2015: 34 · 2014: 26 · 2013: 5
- FWCI
- 20.81
- Type
- journal article
- Language
- en
- Open access
- green
- arxiv.org
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- arXiv (Cornell University) (submittedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- MPG.PuRe (Max Planck Society) (submittedVersion)
- arXiv (Cornell University)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biophysics › Spectroscopy Techniques in Biomedical and Chemical Research
- Physical Sciences › Physics and Astronomy › Atomic and Molecular Physics, and Optics › Laser-Matter Interactions and Applications
- Physical Sciences › Chemistry › Spectroscopy › Spectroscopy and Laser Applications
- Keywords
- coherent anti-Stokes Raman spectroscopy, laser frequency combs, label-free molecular imaging, nonlinear optical microscopy
- MeSH terms
- Lasers, Spectrum Analysis, Raman, Time Factors, Vibration
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