The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Mitochondrial reactive oxygen species regulate the induction of CD8+ T cells by plasmacytoid dendritic cells
Open accessAbstract
Cross-presentation allows exogenous antigen presentation in association with major histocompatibility complex class I molecules, a process crucial for the priming of CD8+ T-cell responses against viruses and tumors. By contrast to conventional dendritic cells (cDC), which cross-present antigens in the steady state, plasmacytoid dendritic cells (pDC) acquire this ability only after stimulation by Toll-like receptor (TLR) ligands. The intracellular pathways accounting for this functional difference are still unknown. Here we show that the induction of cross-presentation by pDCs is regulated by mitochondria through a reactive oxygen species (ROS)-dependent mechanism, involving pH alkalization and antigen protection. The reduction of mitochondrial ROS production dramatically decreases the cross-presentation capacity of pDCs, leading to a strong reduction of their capacity to trigger CD8+ T-cell responses. Our results demonstrate the importance of mitochondrial metabolism in pDC biology, particularly for the induction of adaptive immune responses.
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Citations
Cites
ROS function in redox signaling and oxidative stress
Schieber, M., & Chandel, N. S. (2014) · Current Biology · doi:10.1016/j.cub.2014.03.034 · Cited by 6,931
Tlr signalling augments macrophage bactericidal activity through mitochondrial ros
West, A. P., Brodsky, I. E., Rahner, C., Woo, D. K., Erdjument-Bromage, H., Tempst, P., Walsh, M. C., Choi, Y., Shadel, G. S., & Ghosh, S. (2011) · Nature · doi:10.1038/nature09973 · Cited by 1,659
Combating oxidative stress in vascular disease: NADPH oxidases as therapeutic targets
Drummond, G. R., Selemidis, S., Griendling, K. K., & Sobey, C. G. (2011) · Nature Reviews Drug Discovery · doi:10.1038/nrd3403 · Cited by 899
Cited by
Zeng, S., Liu, X., Kafuti, Y. S., Kim, H., Wang, J., Peng, X., Li, H., & Yoon, J. (2023) · Chemical Society Reviews · doi:10.1039/d2cs00799a · Cited by 341
Cross-presentation of exogenous antigens on MHC I molecules
Colbert, J. D., Cruz, F. M., & Rock, K. L. (2020) · Current Opinion in Immunology · doi:10.1016/j.coi.2019.12.005 · Cited by 150
To, E. E., Erlich, J. R., Liong, F., Luong, R., Liong, S., Esaq, F., Oseghale, O., Anthony, D., McQualter, J., Bozinovski, S., et al. (2020) · Antioxidants & Redox Signaling · doi:10.1089/ars.2019.7727 · Cited by 88
Metadata
- Authors
- Oberkampf, M., Guillerey, C., Mouriès, J., Rosenbaum, P., Fayolle, C., Bobard, A., Savina, A., Ogier-Denis, E., Enninga, J., Amigorena, S., Leclerc, C., & Dadaglio, G.
- Venue
- Nature Communications
- Published
- 2018-06-08
- Volume
- 9
- Issue
- 1
- Pages
- 2241-2241
- ISSN
- 2041-1723 (ISSN-L)
- OpenAlex
- W2806090135
- Cited by
- 171
- References
- 3
- FWCI
- 4.88
- Type
- journal article
- Language
- en
- Open access
- gold
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- Oberkampf, M., Guillerey, C., Mouriès, J., Rosenbaum, P., Fayolle, C., Bobard, A., Savina, A., Ogier-Denis, E., Enninga, J., Amigorena, S., Leclerc, C., & Dadaglio, G. (2018). Mitochondrial reactive oxygen species regulate the induction of CD8+ T cells by plasmacytoid dendritic cells. Nature Communications. https://doi.org/10.1038/s41467-018-04686-8
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