The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Global identification of Arabidopsis lncRNAs reveals the regulation of MAF4 by a natural antisense RNA
Open accessAbstract
Long non-coding RNAs (lncRNAs) have emerged as important regulators of gene expression and plant development. Here, we identified 6,510 lncRNAs in Arabidopsis under normal or stress conditions. We found that the expression of natural antisense transcripts (NATs) that are transcribed in the opposite direction of protein-coding genes often positively correlates with and is required for the expression of their cognate sense genes. We further characterized MAS, a NAT-lncRNA produced from the MADS AFFECTING FLOWERING4 (MAF4) locus. MAS is induced by cold and indispensable for the activation of MAF4 transcription and suppression of precocious flowering. MAS activates MAF4 by interacting with WDR5a, one core component of the COMPASS-like complexes, and recruiting WDR5a to MAF4 to enhance histone 3 lysine 4 trimethylation (H3K4me3). Our study greatly extends the repertoire of lncRNAs in Arabidopsis and reveals a role for NAT-lncRNAs in regulating gene expression in vernalization response and likely in other biological processes.
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Cites
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Langmead, B., Trapnell, C., Pop, M., & Salzberg, S. L. (2009) · Genome Biology · doi:10.1186/gb-2009-10-3-r25 · Cited by 21,849
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The landscape of long noncoding RNAs in the human transcriptome
Iyer, M. K., Niknafs, Y. S., Malik, R., Singhal, U., Sahu, A., Hosono, Y., Barrette, T. R., Prensner, J. R., Evans, J. R., Zhao, S., et al. (2015) · Nature Genetics · doi:10.1038/ng.3192 · Cited by 2,738
Cited by
Baillo, E. H., Kimotho, R. N., Zhang, Z., & Xu, P. (2019) · Genes · doi:10.3390/genes10100771 · Cited by 658
Epigenetic regulation in plant abiotic stress responses
Chang, Y., Zhu, C., Jiang, J., Zhang, H., Zhu, J., & Duan, C. (2020) · Journal of Integrative Plant Biology · doi:10.1111/jipb.12901 · Cited by 533
Yadav, A., Mathan, J., Dubey, A. K., & Singh, A. (2024) · Non-Coding RNA · doi:10.3390/ncrna10010013 · Cited by 83
Noncoding RNA-Mediated Regulation of DNA Methylation: Insights into Plant Epigenetic Mechanisms
Ali, S., & Tang, Y. (2025) · Journal of Plant Growth Regulation · doi:10.1007/s00344-024-11462-0 · Cited by 24
Metadata
- Authors
- Zhao, X., Li, J., Lian, B., Gu, H., Li, Y., & Qi, Y.
- Venue
- Nature Communications
- Published
- 2018-11-29
- Volume
- 9
- Issue
- 1
- Pages
- 5056-5056
- ISSN
- 2041-1723 (ISSN-L)
- OpenAlex
- W2900584322
- Cited by
- 372
- References
- 3
- FWCI
- 24.28
- Type
- journal article
- Language
- en
- Open access
- gold
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