The DOI matches its Crossref record; 18 of the 18 references it cites were found in a registry or an index.
LC3/GABARAPs drive ubiquitin-independent recruitment of Optineurin and NDP52 to amplify mitophagy
Open accessAbstract
Current models of selective autophagy dictate that autophagy receptors, including Optineurin and NDP52, link cargo to autophagosomal membranes. This is thought to occur via autophagy receptor binding to Atg8 homologs (LC3/GABARAPs) through an LC3 interacting region (LIR). The LIR motif within autophagy receptors is therefore widely recognised as being essential for selective sequestration of cargo. Here we show that the LIR motif within OPTN and NDP52 is dispensable for Atg8 recruitment and selectivity during PINK1/Parkin mitophagy. Instead, Atg8s play a critical role in mediating ubiquitin-independent recruitment of OPTN and NDP52 to growing phagophore membranes via the LIR motif. The additional recruitment of OPTN and NDP52 amplifies mitophagy through an Atg8-dependent positive feedback loop. Rather than functioning in selectivity, our discovery of a role for the LIR motif in mitophagy amplification points toward a general mechanism by which Atg8s can recruit autophagy factors to drive autophagosome growth and amplify selective autophagy.
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The ubiquitin kinase PINK1 recruits autophagy receptors to induce mitophagy
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Self-citationThe Roles of PINK1, Parkin, and Mitochondrial Fidelity in Parkinson’s Disease
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PINK1-dependent recruitment of Parkin to mitochondria in mitophagy
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Self-citationCargo recognition and degradation by selective autophagy
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Metadata
- Authors
- Padman, B. S., Nguyen, T. N., Uoselis, L., Skulsuppaisarn, M., Nguyen, L. K., & Lazarou, M.
- Venue
- Nature Communications
- Published
- 2019-01-24
- Volume
- 10
- Issue
- 1
- Pages
- 408-408
- ISSN
- 2041-1723 (ISSN-L)
- OpenAlex
- W2913143413
- Cited by
- 233
- References
- 18
- FWCI
- 19.37
- Type
- journal article
- Language
- en
- Open access
- gold
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- Padman, B. S., Nguyen, T. N., Uoselis, L., Skulsuppaisarn, M., Nguyen, L. K., & Lazarou, M. (2019). LC3/GABARAPs drive ubiquitin-independent recruitment of Optineurin and NDP52 to amplify mitophagy. Nature Communications. https://doi.org/10.1038/s41467-019-08335-6
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