The DOI matches its Crossref record; 77 of the 77 references it cites were found in a registry or an index.
Atypical functional connectome hierarchy in autism
Open accessAbstract
One paradox of autism is the co-occurrence of deficits in sensory and higher-order socio-cognitive processing. Here, we examined whether these phenotypical patterns may relate to an overarching system-level imbalance—specifically a disruption in macroscale hierarchy affecting integration and segregation of unimodal and transmodal networks. Combining connectome gradient and stepwise connectivity analysis based on task-free functional magnetic resonance imaging (fMRI), we demonstrated atypical connectivity transitions between sensory and higher-order default mode regions in a large cohort of individuals with autism relative to typically-developing controls. Further analyses indicated that reduced differentiation related to perturbed stepwise connectivity from sensory towards transmodal areas, as well as atypical long-range rich-club connectivity. Supervised pattern learning revealed that hierarchical features predicted deficits in social cognition and low-level behavioral symptoms, but not communication-related symptoms. Our findings provide new evidence for imbalances in network hierarchy in autism, which offers a parsimonious reference frame to consolidate its diverse features.
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1 retracted
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RetractedThe Brain's Default Network: Anatomy, Function, and Relevance to Disease
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The organization of the human cerebral cortex estimated by intrinsic functional connectivity
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Does the autistic child have a “theory of mind” ?
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Distributed hierarchical processing in the primate cerebral cortex
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Zeng, Y., Wei, Z., Yu, W., Yin, R., Yuan, Y., Li, B., Tang, Z., Lu, Y., & Yang, Y. (2022) · Briefings in Bioinformatics · doi:10.1093/bib/bbac297 · Cited by 211
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Katsumi, Y., Kamona, N., Zhang, J., Bunce, J. G., Hutchinson, J. B., Yarossi, M., Tunik, E., Quigley, K. S., Dickerson, B. C., & Barrett, L. F. (2021) · doi:10.1101/2021.09.01.456844 · Cited by 89
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Metadata
- Authors
- Hong, S.-J., Vos de Wael, R., Bethlehem, R. A. I., Lariviere, S., Paquola, C., Valk, S. L., Milham, M. P., Di Martino, A., Margulies, D. S., Smallwood, J., & Bernhardt, B. C.
- Venue
- Nature Communications
- Published
- 2019-03-04
- Volume
- 10
- Issue
- 1
- Pages
- 1022-1022
- ISSN
- 2041-1723 (ISSN-L)
- OpenAlex
- W2797702265
- Cited by
- 531
- References
- 77
- FWCI
- 25.82
- Type
- journal article
- Language
- en
- Open access
- gold
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- Hong, S.-J., Vos de Wael, R., Bethlehem, R. A. I., Lariviere, S., Paquola, C., Valk, S. L., Milham, M. P., Di Martino, A., Margulies, D. S., Smallwood, J., & Bernhardt, B. C. (2019). Atypical functional connectome hierarchy in autism. Nature Communications. https://doi.org/10.1038/s41467-019-08944-1
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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