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Cited by 448Hemostasis and retained surgical itemsHydrogels: synthesis, properties, applicationsWound Healing and Treatments

Polymeric hydrogel systems as emerging biomaterial platforms to enable hemostasis and wound healing

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Pourshahrestani, Sara, Zeimaran, Ehsan, Kadri, Nahrizul Adib, Mutlu, Nurshen, Boccaccini, Aldo R.·2020·Advanced Healthcare Materials
DOI 10.1002/adhm.202000905
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Abstract

Broad interest in developing new hemostatic technologies arises from unmet needs in mitigating uncontrolled hemorrhage in emergency, surgical, and battlefield settings. Although a variety of hemostats, sealants, and adhesives are available, development of ideal hemostatic compositions that offer a range of remarkable properties including capability to effectively and immediately manage bleeding, excellent mechanical properties, biocompatibility, biodegradability, antibacterial effect, and strong tissue adhesion properties, under wet and dynamic conditions, still remains a challenge. Benefiting from tunable mechanical properties, high porosity, biocompatibility, injectability and ease of handling, polymeric hydrogels with outstanding hemostatic properties have been receiving increasing attention over the past several years. In this review, after shedding light on hemostasis and wound healing processes, the most recent progresses in hydrogel systems engineered from natural and synthetic polymers for hemostatic applications are discussed based on a comprehensive literature review. Most studies described used in vivo models with accessible and compressible wounds to assess the hemostatic performance of hydrogels. The challenges that need to be tackled to accelerate the translation of these novel hemostatic hydrogel systems to clinical practice are emphasized and future directions for research in the field are presented.

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  • CMC absorbs water and swells, forming a hydrogel-like layer that physically separates tissues during healing, preventing direct tissue contact and reducing adhesion formation.

    “CMC absorbs water and swells, forming a hydrogel-like layer that physically separates tissues during healing, preventing direct tissue contact and reducing adhesion formation [135].”

    From Biomaterials in Postoperative Adhesion Barriers and Uterine Tissue Engineering (2025) · cites this paper as [135]

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Cited by

Sorted by citations

Authors
Pourshahrestani, S., Zeimaran, E., Kadri, N. A., Mutlu, N., & Boccaccini, A. R.
Affiliations
  • University of Malaya (MY)
  • Trencianska Univerzita Alexandra Dubceka V Trencine (SK)
  • Friedrich-Alexander-Universität Erlangen-Nürnberg (DE)
Corresponding author
  • Pourshahrestani, Sara
  • Boccaccini, Aldo R.
ORCID
Venue
Advanced Healthcare Materials
Publisher
Wiley
Published
2020-09-16
Volume
9
Issue
20
Pages
e2000905-e2000905
ISSN
  • 2192-2640 (ISSN-L)
  • 2192-2659
DOI
10.1002/adhm.202000905
OpenAlex
W3087576394
Cited by
448
References
5
Citations by year
2026: 78 · 2025: 82 · 2024: 99 · 2023: 80 · 2022: 65 · 2021: 44
FWCI
7.50
Type
journal article
Language
en
Open access
Licence
Locations
  • Advanced Healthcare Materials (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
  • OPUS FAU (Kooperativer Bibliotheksverbund Berlin-Brandenburg (KOBV), on behalf of the Universitätsbibliothek Erlangen-Nürnberg) (submittedVersion, cc-by-nc-nd)
Funders
Universiti Malaya (GPF030A‐2018)
Topics
  • Health Sciences › Medicine › Hematology › Hemostasis and retained surgical items
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Hydrogels: synthesis, properties, applications
  • Health Sciences › Medicine › Rehabilitation › Wound Healing and Treatments
Keywords
polymer hydrogels, hemostasis, wound healing, hemostatic materials, uncontrolled bleeding, natural polymers, synthetic polymers, tissue adhesion, biocompatibility, biodegradability, antibacterial hydrogel, injectable hydrogel, clinical translation
MeSH terms
Biocompatible Materials, Hemostasis, Polymers, Wound Healing, Hydrogels

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