The DOI matches its Crossref record; 45 of the 45 references it cites were found in a registry or an index.
Framework nucleic acids as programmable carrier for transdermal drug delivery
Open accessAbstract
DNA nanostructures are promising drug carriers with their intrinsic biocompatibility, uniformity and versatility. However, rapid serum disintegration leads to low bioavailability at targeted sites following systemic administration, hindering their biomedical applications. Here we demonstrate transdermal delivery of framework nucleic acids (FNAs) through topical applications. By designing FNAs with distinct shapes and sizes, we interrogate their penetration on mice and human skin explant. Skin histology reveals size-dependent penetration, with FNAs ≤75 nm effectively reaching dermis layer. 17 nm-tetrahedral FNAs show greatest penetration to 350 µm from skin periphery. Importantly, structural integrity is maintained during the skin penetration. Employing a mouse melanoma model, topical application of doxorubicin-loaded FNAs accommodates ≥2-fold improvement in drug accumulation and tumor inhibition relative to topically-applied free doxorubicin, or doxorubicin loaded in liposomes and polymeric nanoparticles. Programmable penetration with minimal systemic biodistribution underlines FNA potential as localized transdermal drug delivery carriers.
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Cites
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Cited by
The biological applications of DNA nanomaterials: current challenges and future directions
Ma, W., Zhan, Y., Zhang, Y., Mao, C., Xie, X., & Lin, Y. (2021) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-021-00727-9 · Cited by 331
Challenges and Perspectives of DNA Nanostructures in Biomedicine
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Smart Nanocarriers for the Delivery of Nucleic Acid‐Based Therapeutics: A Comprehensive Review
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Nanocarrier imaging at single-cell resolution across entire mouse bodies with deep learning
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Metadata
- Authors
- Wiraja, C., Zhu, Y., Lio, D. C. S., Yeo, D. C., Xie, M., Fang, W., Li, Q., Zheng, M., Van Steensel, M., Wang, L., Fan, C., & Xu, C.
- Venue
- Nature Communications
- Published
- 2019-03-08
- Volume
- 10
- Issue
- 1
- Pages
- 1147-1147
- ISSN
- 2041-1723 (ISSN-L)
- OpenAlex
- W2918782245
- Cited by
- 294
- References
- 45
- FWCI
- 11.93
- Type
- journal article
- Language
- en
- Open access
- gold
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- Wiraja, C., Zhu, Y., Lio, D. C. S., Yeo, D. C., Xie, M., Fang, W., Li, Q., Zheng, M., Van Steensel, M., Wang, L., Fan, C., & Xu, C. (2019). Framework nucleic acids as programmable carrier for transdermal drug delivery. Nature Communications. https://doi.org/10.1038/s41467-019-09029-9
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