The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.
Caspase-1 initiates apoptosis in the absence of gasdermin D
Open accessAbstract
Caspase-1 activated in inflammasomes triggers a programmed necrosis called pyroptosis, which is mediated by gasdermin D (GSDMD). However, GSDMD-deficient cells are still susceptible to caspase-1-mediated cell death. Therefore, here, we investigate the mechanism of caspase-1-initiated cell death in GSDMD-deficient cells. Inflammasome stimuli induce apoptosis accompanied by caspase-3 activation in GSDMD-deficient macrophages, which largely relies on caspase-1. Chemical dimerization of caspase-1 induces pyroptosis in GSDMD-sufficient cells, but apoptosis in GSDMD-deficient cells. Caspase-1-induced apoptosis involves the Bid-caspase-9-caspase-3 axis, which can be followed by GSDME-dependent secondary necrosis/pyroptosis. However, Bid ablation does not completely abolish the cell death, suggesting the existence of an additional mechanism. Furthermore, cortical neurons and mast cells exhibit little or low GSDMD expression and undergo apoptosis after oxygen glucose deprivation and nigericin stimulation, respectively, in a caspase-1- and Bid-dependent manner. This study clarifies the molecular mechanism and biological roles of caspase-1-induced apoptosis in GSDMD-low/null cell types.
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Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling
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Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores
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Chemotherapy drugs induce pyroptosis through caspase-3 cleavage of a gasdermin
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Non-canonical inflammasome activation targets caspase-11
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Mitochondrial ROS promotes susceptibility to infection via gasdermin D-mediated necroptosis
Weindel, C. G., Martinez, E. L., Zhao, X., Mabry, C. J., Bell, S. L., Vail, K. J., Coleman, A. K., VanPortfliet, J. J., Zhao, B., Wagner, A. R., et al. (2022) · Cell · doi:10.1016/j.cell.2022.06.038 · Cited by 396
Modes of Regulated Cell Death in Cancer
Koren, E., & Fuchs, Y. (2021) · Cancer Discovery · doi:10.1158/2159-8290.cd-20-0789 · Cited by 371
Zirngibl, M., Assinck, P., Sizov, A., Caprariello, A. V., & Plemel, J. R. (2022) · Molecular Neurodegeneration · doi:10.1186/s13024-022-00538-8 · Cited by 233
Lee, E., Song, C.-H., Bae, S.-J., Ha, K.-T., & Karki, R. (2023) · Experimental & Molecular Medicine · doi:10.1038/s12276-023-01069-y · Cited by 164
Metadata
- Authors
- Tsuchiya, K., Nakajima, S., Hosojima, S., Thi Nguyen, D., Hattori, T., Manh Le, T., Hori, O., Mahib, M. R., Yamaguchi, Y., Miura, M., Kinoshita, T., Kushiyama, H., Sakurai, M., Shiroishi, T., & Suda, T.
- Venue
- Nature Communications
- Published
- 2019-05-07
- Volume
- 10
- Issue
- 1
- Pages
- 2091-2091
- ISSN
- 2041-1723 (ISSN-L)
- OpenAlex
- W2944565286
- Cited by
- 495
- References
- 14
- FWCI
- 16.83
- Type
- journal article
- Language
- en
- Open access
- gold
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- Tsuchiya, K., Nakajima, S., Hosojima, S., Thi Nguyen, D., Hattori, T., Manh Le, T., Hori, O., Mahib, M. R., Yamaguchi, Y., Miura, M., Kinoshita, T., Kushiyama, H., Sakurai, M., Shiroishi, T., & Suda, T. (2019). Caspase-1 initiates apoptosis in the absence of gasdermin D. Nature Communications. https://doi.org/10.1038/s41467-019-09753-2
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