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Cited by 37Calcium Carbonate Crystallization and InhibitionOrigins and Evolution of LifeCrystallization and Solubility Studies

Homochirality in biomineral suprastructures induced by assembly of single-enantiomer amino acids from a nonracemic mixture

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Jiang, Wenge, Athanasiadou, Dimitra, Zhang, Shaodong, Demichelis, Raffaella, Koziara, Katarzyna B., Raiteri, Paolo, Nelea, Valentin, Mi, Wenbo +3 more·2019·Nature Communications
DOI 10.1038/s41467-019-10383-xPMC PMC6534569
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Abstract

Since Pasteur first successfully separated right-handed and left-handed tartrate crystals in 1848, the understanding of how homochirality is achieved from enantiomeric mixtures has long been incomplete. Here, we report on a chirality dominance effect where organized, three-dimensional homochiral suprastructures of the biomineral calcium carbonate (vaterite) can be induced from a mixed nonracemic amino acid system. Right-handed (counterclockwise) homochiral vaterite helicoids are induced when the amino acid l-Asp is in the majority, whereas left-handed (clockwise) homochiral morphology is induced when d-Asp is in the majority. Unexpectedly, the Asp that incorporates into the homochiral vaterite helicoids maintains the same enantiomer ratio as that of the initial growth solution, thus showing chirality transfer without chirality amplification. Changes in the degree of chirality of the vaterite helicoids are postulated to result from the extent of majority enantiomer assembly on the mineral surface. These mechanistic insights potentially have major implications for high-level advanced materials synthesis.

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  • Vaterite helicoids from non-racemic aspartic acid are single-handed, but incorporation shows no chiral amplification.

    “Vaterite helicoids, produced by crystallization of CaCO 3 in the presence of non-racemic mixtures of aspartic acid, were found to be single-handed (Fig. 10b).260 Enantiomeric ratio are identical in the helicoids and in solution, i.e. incorporation of aspartic acid in valerite displays no chiral amplification effect.”

    From Possible chemical and physical scenarios towards biological homochirality (2022) · cites this paper as [260]

  • Enantiopure amino acids induce asymmetric morphologies of CaCO3-based crystals.

    “Asymmetric morphologies of CaCO 3 -based crystals induced by enantiopure amino acids.”

    From Possible chemical and physical scenarios towards biological homochirality (2022) · cites this paper as [260]

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Cited by

Sorted by citations

Authors
Jiang, W., Athanasiadou, D., Zhang, S., Demichelis, R., Koziara, K. B., Raiteri, P., Nelea, V., Mi, W., Ma, J.-A., Gale, J. D., & McKee, M. D.
Affiliations
  • Tianjin University (CN)
  • McGill University (CA)
  • Shanghai Jiao Tong University (CN)
  • Curtin University (AU)
Corresponding author
McKee, Marc D.
ORCID
Venue
Nature Communications
Publisher
Springer Science and Business Media LLC
Published
2019-05-24
Volume
10
Issue
1
Pages
2318-2318
ISSN
2041-1723 (ISSN-L)
DOI
10.1038/s41467-019-10383-x
PMC
PMC6534569
OpenAlex
W2945016021
Cited by
37
References
3
Citations by year
2026: 1 · 2025: 7 · 2024: 9 · 2023: 6 · 2022: 5 · 2021: 7 · 2019: 1 · 2018: 1
FWCI
0.92
Type
journal article
Language
en
Open access
Licence
Locations
  • Nature Communications (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • RePEc: Research Papers in Economics (submittedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
  • eSpace (Curtin University) (submittedVersion, cc-by)
  • Open Access CRIS of the University of Bern
Funders
  • Canadian Network for Research and Innovation in Machining Technology, Natural Sciences and Engineering Research Council of Canada (RGPIN-2016-05031)
  • Natural Science Foundation of Shanghai (18ZR1420800)
Topics
  • Physical Sciences › Materials Science › Biomaterials › Calcium Carbonate Crystallization and Inhibition
  • Physical Sciences › Physics and Astronomy › Astronomy and Astrophysics › Origins and Evolution of Life
  • Physical Sciences › Materials Science › Materials Chemistry › Crystallization and Solubility Studies
Keywords
homochirality, chirality transfer, calcium carbonate biomineralization, vaterite, amino acid enantiomers, L-aspartic acid, D-aspartic acid, chirality amplification, origin of homochirality
MeSH terms
Asparagine, Calcium Carbonate, Molecular Conformation, Stereoisomerism

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