The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Mild photothermal therapy potentiates anti-PD-L1 treatment for immunologically cold tumors via an all-in-one and all-in-control strategy
Open accessAbstract
One of the main challenges for immune checkpoint blockade antibodies lies in malignancies with limited T-cell responses or immunologically “cold” tumors. Inspired by the capability of fever-like heat in inducing an immune-favorable tumor microenvironment, mild photothermal therapy (PTT) is proposed to sensitize tumors to immune checkpoint inhibition and turn “cold” tumors “hot.” Here we present a combined all-in-one and all-in-control strategy to realize a local symbiotic mild photothermal-assisted immunotherapy (SMPAI). We load both a near-infrared (NIR) photothermal agent IR820 and a programmed death-ligand 1 antibody (aPD-L1) into a lipid gel depot with a favorable property of thermally reversible gel-to-sol phase transition. Manually controlled NIR irradiation regulates the release of aPD-L1 and, more importantly, increases the recruitment of tumor-infiltrating lymphocytes and boosts T-cell activity against tumors. In vivo antitumor studies on 4T1 and B16F10 models demonstrate that SMPAI is an effective and promising strategy for treating “cold” tumors.
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Cites
PD-1 blockade induces responses by inhibiting adaptive immune resistance
Tumeh, P. C., Harview, C. L., Yearley, J. H., Shintaku, I. P., Taylor, E. J. M., Robert, L., Chmielowski, B., Spasic, M., Henry, G., Ciobanu, V., et al. (2014) · Nature · doi:10.1038/nature13954 · Cited by 6,609
Melanoma-intrinsic β-catenin signalling prevents anti-tumour immunity
Spranger, S., Bao, R., & Gajewski, T. F. (2015) · Nature · doi:10.1038/nature14404 · Cited by 2,830
Effector and memory T-cell differentiation: implications for vaccine development
Kaech, S. M., Wherry, E. J., & Ahmed, R. (2002) · Nature Reviews Immunology · doi:10.1038/nri778 · Cited by 1,865
Lineage relationship and protective immunity of memory CD8 T cell subsets
Wherry, E. J., Teichgräber, V., Becker, T. C., Masopust, D., Kaech, S. M., Antia, R., von Andrian, U. H., & Ahmed, R. (2003) · Nature Immunology · doi:10.1038/ni889 · Cited by 1,864
Cited by
Nanoagent‐Promoted Mild‐Temperature Photothermal Therapy for Cancer Treatment
Gao, G., Sun, X., & Liang, G. (2021) · Advanced Functional Materials · doi:10.1002/adfm.202100738 · Cited by 359
Recent Advances in 3D Printing of Smart Scaffolds for Bone Tissue Engineering and Regeneration
Yuan, X., Zhu, W., Yang, Z., He, N., Chen, F., Han, X., & Zhou, K. (2024) · Advanced Materials · doi:10.1002/adma.202403641 · Cited by 339
Qing, S., Lyu, C., Zhu, L., Pan, C., Wang, S., Li, F., Wang, J., Yue, H., Gao, X., Jia, R., et al. (2020) · Advanced Materials · doi:10.1002/adma.202002085 · Cited by 309
Dong, S., Dong, Y., Zhao, Z., Liu, J., Liu, S., Feng, L., He, F., Gai, S., Xie, Y., & Yang, P. (2023) · Journal of the American Chemical Society · doi:10.1021/jacs.2c09608 · Cited by 267
Nanosensitizer-mediated augmentation of sonodynamic therapy efficacy and antitumor immunity
Li, Y., Chen, W., Kang, Y., Zhen, X., Zhou, Z., Liu, C., Chen, S., Huang, X., Liu, H.-J., Koo, S., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-42509-7 · Cited by 235
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Metadata
- Authors
- Huang, L., Li, Y., Du, Y., Zhang, Y., Wang, X., Ding, Y., Yang, X., Meng, F., Tu, J., Luo, L., & Sun, C.
- Venue
- Nature Communications
- Published
- 2019-10-25
- Volume
- 10
- Issue
- 1
- Pages
- 4871-4871
- ISSN
- 2041-1723 (ISSN-L)
- OpenAlex
- W2981614789
- Cited by
- 596
- References
- 4
- FWCI
- 20.90
- Type
- journal article
- Language
- en
- Open access
- gold
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- Huang, L., Li, Y., Du, Y., Zhang, Y., Wang, X., Ding, Y., Yang, X., Meng, F., Tu, J., Luo, L., & Sun, C. (2019). Mild photothermal therapy potentiates anti-PD-L1 treatment for immunologically cold tumors via an all-in-one and all-in-control strategy. Nature Communications. https://doi.org/10.1038/s41467-019-12771-9
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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