Lineage relationship and protective immunity of memory CD8 T cell subsets

Wherry, E. John; Teichgräber, Volker; Becker, Todd C.; Masopust, David; Kaech, Susan M.; Antia, Rustom; von Andrian, Ulrich H.; Ahmed, Rafi

doi:10.1038/ni889

Cited by 1,864T-cell and B-cell ImmunologyImmunotherapy and Immune ResponsesImmune responses and vaccinations

Lineage relationship and protective immunity of memory CD8 T cell subsets

Wherry, E. John, Teichgräber, Volker, Becker, Todd C., Masopust, David, Kaech, Susan M., Antia, Rustom, von Andrian, Ulrich H., Ahmed, Rafi·2003·Nature Immunology

DOI 10.1038/ni889

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Abstract

Memory CD8 T cells can be divided into two subsets, central (T(CM)) and effector (T(EM)), but their lineage relationships and their ability to persist and confer protective immunity are not well understood. Our results show that T(CM) have a greater capacity than T(EM) to persist in vivo and are more efficient in mediating protective immunity because of their increased proliferative potential. We also demonstrate that, following antigen clearance, T(EM) convert to T(CM) and that the duration of this differentiation is programmed within the first week after immunization. We propose that T(CM) and T(EM) do not necessarily represent distinct subsets, but are part of a continuum in a linear naive --> effector --> T(EM) --> T(CM) differentiation pathway.

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Whether CD4+ and CD8+ T cells are central memory or effector memory affects their persistence, circulation, tissue entry, and recall responses.
“the central memory (CM) or effector memory (EM) differentiation states of CD4+ and CD8+ T cells have implications for durability, recirculation, tissue access, and responses upon antigen re-exposure (Kaech et al., 2002; Martin and Badovinac, 2018; Wherry et al., 2003).”
From Rapid induction of antigen-specific CD4+ T cells is associated with coordinated humoral and cellular immunity to SARS-CoV-2 mRNA vaccination (2021) · cites this paper as Wherry et al., 2003

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Authors: Wherry, E. J., Teichgräber, V., Becker, T. C., Masopust, D., Kaech, S. M., Antia, R., von Andrian, U. H., & Ahmed, R.
Affiliations: Emory University (US)
Corresponding author: Ahmed, Rafi
ORCID: Wherry, E. John
Teichgräber, Volker
Masopust, David
Kaech, Susan M.
Antia, Rustom
Ahmed, Rafi
Venue: Nature Immunology
Publisher: Springer Science and Business Media LLC
Published: 2003-02-03
Volume: 4
Issue: 3
Pages: 225-234
ISSN: 1529-2908 (ISSN-L)
1529-2916
DOI: 10.1038/ni889
OpenAlex: W2029128444
Cited by: 1,864
References: 57
Citations by year: 2026: 27 · 2025: 44 · 2024: 47 · 2023: 55 · 2022: 61 · 2021: 65 · 2020: 59 · 2019: 59 · 2018: 54 · 2017: 60 · 2016: 68 · 2015: 50 · 2014: 74 · 2013: 92 · 2012: 84
FWCI: 47.89
Type: journal article
Language: en
Open access: closed
Licence: www.springernature.com/gp/researchers/text-and-data-mining (tdm)
www.springernature.com/gp/researchers/text-and-data-mining (vor)
Locations: Nature Immunology (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of General Medical Sciences (T32GM008169)
National Institute of Allergy and Infectious Diseases (AI44644, AI 30048)
Topics: Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
Life Sciences › Immunology and Microbiology › Immunology › Immune responses and vaccinations
Keywords: memory CD8+ T cells, central memory T cells, effector memory T cells, T cell lineage, T cell differentiation, T cell proliferation, protective immunity, antigen clearance, naive T cells, T cell persistence
MeSH terms: Animals, Cell Communication, Cell Division, Immunologic Memory, Listeriosis, Listeria monocytogenes, Lymphocytic Choriomeningitis, Lymphocytic choriomeningitis virus, Mice, Transgenic, CD8-Positive T-Lymphocytes, Cell Lineage, Mice

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Lineage relationship and protective immunity of memory CD8 T cell subsets

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