The DOI matches its Crossref record; 71 of the 71 references it cites were found in a registry or an index.
YTHDF1 links hypoxia adaptation and non-small cell lung cancer progression
Open accessAbstract
Hypoxia occurs naturally at high-altitudes and pathologically in hypoxic solid tumors. Here, we report that genes involved in various human cancers evolved rapidly in Tibetans and six Tibetan domestic mammals compared to reciprocal lowlanders. Furthermore, m 6 A modified mRNA binding protein YTHDF1, one of evolutionary positively selected genes for high-altitude adaptation is amplified in various cancers, including non-small cell lung cancer (NSCLC). We show that YTHDF1 deficiency inhibits NSCLC cell proliferation and xenograft tumor formation through regulating the translational efficiency of CDK2, CDK4, and cyclin D1, and that YTHDF1 depletion restrains de novo lung adenocarcinomas (ADC) progression. However, we observe that YTHDF1 high expression correlates with better clinical outcome, with its depletion rendering cancerous cells resistant to cisplatin (DDP) treatment. Mechanistic studies identified the Keap1-Nrf2-AKR1C1 axis as the downstream mediator of YTHDF1. Together, these findings highlight the critical role of YTHDF1 in both hypoxia adaptation and pathogenesis of NSCLC.
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Li, Q., Ni, Y., Zhang, L., Jiang, R., Xu, J., Yang, H., Hu, Y., Qiu, J., Pu, L., Tang, J., et al. (2021) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-020-00453-8 · Cited by 380
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Metadata
- Authors
- Shi, Y., Fan, S., Wu, M., Zuo, Z., Li, X., Jiang, L., Shen, Q., Xu, P., Zeng, L., Zhou, Y., Huang, Y., Yang, Z., Zhou, J., Gao, J., Zhou, H., Xu, S., Ji, H., Shi, P., Wu, D.-D., Yang, C., & Chen, Y.
- Venue
- Nature Communications
- Published
- 2019-10-25
- Volume
- 10
- Issue
- 1
- Pages
- 4892-4892
- ISSN
- 2041-1723 (ISSN-L)
- OpenAlex
- W2982058491
- Cited by
- 363
- References
- 71
- FWCI
- 16.11
- Type
- journal article
- Language
- en
- Open access
- gold
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- Shi, Y., Fan, S., Wu, M., Zuo, Z., Li, X., Jiang, L., Shen, Q., Xu, P., Zeng, L., Zhou, Y., Huang, Y., Yang, Z., Zhou, J., Gao, J., Zhou, H., Xu, S., Ji, H., Shi, P., Wu, D.-D., . . . Chen, Y. (2019). YTHDF1 links hypoxia adaptation and non-small cell lung cancer progression. Nature Communications. https://doi.org/10.1038/s41467-019-12801-6
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