The DOI matches its Crossref record; 44 of the 44 references it cites were found in a registry or an index.
Theabrownin from Pu-erh tea attenuates hypercholesterolemia via modulation of gut microbiota and bile acid metabolism
Open accessAbstract
Pu-erh tea displays cholesterol-lowering properties, but the underlying mechanism has not been elucidated. Theabrownin is one of the most active and abundant pigments in Pu-erh tea. Here, we show that theabrownin alters the gut microbiota in mice and humans, predominantly suppressing microbes associated with bile-salt hydrolase (BSH) activity. Theabrownin increases the levels of ileal conjugated bile acids (BAs) which, in turn, inhibit the intestinal FXR-FGF15 signaling pathway, resulting in increased hepatic production and fecal excretion of BAs, reduced hepatic cholesterol, and decreased lipogenesis. The inhibition of intestinal FXR-FGF15 signaling is accompanied by increased gene expression of enzymes in the alternative BA synthetic pathway, production of hepatic chenodeoxycholic acid, activation of hepatic FXR, and hepatic lipolysis. Our results shed light into the mechanisms behind the cholesterol- and lipid-lowering effects of Pu-erh tea, and suggest that decreased intestinal BSH microbes and/or decreased FXR-FGF15 signaling may be potential anti-hypercholesterolemia and anti-hyperlipidemia therapies.
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Cites
Intestinal Crosstalk between Bile Acids and Microbiota and Its Impact on Host Metabolism
Wahlström, A., Sayin, S. I., Marschall, H.-U., & Bäckhed, F. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.05.005 · Cited by 2,851
Bile salt biotransformations by human intestinal bacteria
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Fibroblast growth factor 15 functions as an enterohepatic signal to regulate bile acid homeostasis
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Targeted Disruption of the Nuclear Receptor FXR/BAR Impairs Bile Acid and Lipid Homeostasis
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Bile Salt Hydrolase Activity in Probiotics
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Regulation of antibacterial defense in the small intestine by the nuclear bile acid receptor
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Cited by
You Are What You Eat—The Relationship between Diet, Microbiota, and Metabolic Disorders—A Review
Moszak, M., Szulińska, M., & Bogdański, P. (2020) · Nutrients · doi:10.3390/nu12041096 · Cited by 397
Targeting the alternative bile acid synthetic pathway for metabolic diseases
Jia, W., Wei, M., Rajani, C., & Zheng, X. (2021) · Protein & Cell · doi:10.1007/s13238-020-00804-9 · Cited by 325
Self-citationHou, Y.-F., Shan, C., Zhuang, S.-Y., Zhuang, Q.-Q., Ghosh, A., Zhu, K.-C., Kong, X.-K., Wang, S.-M., Gong, Y.-L., Yang, Y.-Y., et al. (2021) · Microbiome · doi:10.1186/s40168-020-00988-6 · Cited by 231
Self-citationLi, M., Wang, S., Li, Y., Zhao, M., Kuang, J., Liang, D., Wang, J., Wei, M., Rajani, C., Ma, X., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-29589-7 · Cited by 175
Self-citationLei, Y., Tang, L., Chen, Q., Wu, L., He, W., Tu, D., Wang, S., Chen, Y., Liu, S., Xie, Z., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-34671-1 · Cited by 104
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Metadata
- Authors
- Huang, F., Zheng, X., Ma, X., Jiang, R., Zhou, W., Zhou, S., Zhang, Y., Lei, S., Wang, S., Kuang, J., Han, X., Wei, M., You, Y., Li, M., Li, Y., Liang, D., Liu, J., Chen, T., Yan, C., Wei, R., Rajani, C., Shen, C., Xie, G., Bian, Z., Li, H., Zhao, A., & Jia, W.
- Venue
- Nature Communications
- Published
- 2019-10-31
- Volume
- 10
- Issue
- 1
- Pages
- 4971-4971
- ISSN
- 2041-1723 (ISSN-L)
- OpenAlex
- W2982531730
- Cited by
- 789
- References
- 44
- FWCI
- 21.13
- Type
- journal article
- Language
- en
- Open access
- gold
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- Huang, F., Zheng, X., Ma, X., Jiang, R., Zhou, W., Zhou, S., Zhang, Y., Lei, S., Wang, S., Kuang, J., Han, X., Wei, M., You, Y., Li, M., Li, Y., Liang, D., Liu, J., Chen, T., Yan, C., . . . Jia, W. (2019). Theabrownin from Pu-erh tea attenuates hypercholesterolemia via modulation of gut microbiota and bile acid metabolism. Nature Communications. https://doi.org/10.1038/s41467-019-12896-x
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