Targeted Disruption of the Nuclear Receptor FXR/BAR Impairs Bile Acid and Lipid Homeostasis
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Mice lacking the nuclear bile acid receptor FXR/BAR developed normally and were outwardly identical to wild-type littermates. FXR/BAR null mice were distinguished from wild-type mice by elevated serum bile acid, cholesterol, and triglycerides, increased hepatic cholesterol and triglycerides, and a proatherogenic serum lipoprotein profile. FXR/BAR null mice also had reduced bile acid pools and reduced fecal bile acid excretion due to decreased expression of the major hepatic canalicular bile acid transport protein. Bile acid repression and induction of cholesterol 7alpha-hydroxylase and the ileal bile acid binding protein, respectively, did not occur in FXR/BAR null mice, establishing the regulatory role of FXR/BAR for the expression of these genes in vivo. These data demonstrate that FXR/BAR is critical for bile acid and lipid homeostasis by virtue of its role as an intracellular bile acid sensor.
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FXR is required for the negative-feedback regulation of bile acid biosynthesis and the enterohepatic cycle.
“FXR is required for the negative-feedback regulation of BA biosynthesis and the enterohepatic cycle (30).”
Cites
The nuclear receptor superfamily: the second decade
Mangelsdorf, D. J., Thummel, C., Beato, M., Herrlich, P., Schütz, G., Umesono, K., Blumberg, B., Kastner, P., Mark, M., Chambon, P., et al. (1995) · Cell · doi:10.1016/0092-8674(95)90199-x · Cited by 6,964 · see citing works
Molecular basis of agonism and antagonism in the oestrogen receptor
Brzozowski, A. M., Pike, A. C. W., Dauter, Z., Hubbard, R. E., Bonn, T., Engström, O., Öhman, L., Greene, G. L., Gustafsson, J.-Å., & Carlquist, M. (1997) · Nature · doi:10.1038/39645 · Cited by 3,355 · see citing works
Identification of a nuclear receptor for bile acids
Makishima, M., Okamoto, A. Y., Repa, J. J., Tu, H., Learned, R. M., Luk, A., Hull, M. V., Lustig, K. D., Mangelsdorf, D. J., & Shan, B. (1999) · Science · doi:10.1126/science.284.5418.1362 · Cited by 2,714 · see citing works
Bile Acids: Natural Ligands for an Orphan Nuclear Receptor
Parks, D. J., Blanchard, S. G., Bledsoe, R. K., Chandra, G., Consler, T. G., Kliewer, S. A., Stimmel, J. B., Willson, T. M., Zavacki, A. M., Moore, D. D., et al. (1999) · Science · doi:10.1126/science.284.5418.1365 · Cited by 2,274 · see citing works
Ligand binding and co-activator assembly of the peroxisome proliferator-activated receptor-γ
Nolte, R. T., Wisely, G. B., Westin, S. K., Cobb, J. E., Lambert, M. H., Kurokawa, R., Rosenfeld, M. G., Willson, T. M., Glass, C. K., & Milburn, M. V. (1998) · Nature · doi:10.1038/25931 · Cited by 1,955 · see citing works
A regulatory cascade of the nuclear receptors FXR, SHP-1, and LRH-1 represses bile acid biosynthesis
Goodwin, B., Jones, S. A., Price, R. R., Watson, M. A., McKee, D. D., Moore, L. B., Galardi, C., Wilson, J. G., Lewis, M. C., Roth, M. E., et al. (2000) · Molecular Cell · doi:10.1016/s1097-2765(00)00051-4 · Cited by 1,940 · see citing works
Lee, S. S. T., Pineau, T., Drago, J., Lee, E. J., Owens, J. W., Kroetz, D. L., Fernández‐Salguero, P. M., Westphal, H., & Gonzalez, F. J. (1995) · Molecular and Cellular Biology · doi:10.1128/mcb.15.6.3012 · Cited by 1,655 · see citing works
Self-citationEndogenous Bile Acids Are Ligands for the Nuclear Receptor FXR/BAR
Wang, H., Chen, J., Hollister, K., Sowers, L. C., & Forman, B. M. (1999) · Molecular Cell · doi:10.1016/s1097-2765(00)80348-2 · Cited by 1,636 · see citing works
Nuclear receptor that identifies a novel retinoic acid response pathway
Mangelsdorf, D. J., Ong, E. S., Dyck, J. A., & Evans, R. M. (1990) · Nature · doi:10.1038/345224a0 · Cited by 1,491 · see citing works
Molecular Basis for Feedback Regulation of Bile Acid Synthesis by Nuclear Receptors
Lu, T. T., Makishima, M., Repa, J. J., Schoonjans, K., Kerr, T. A., Auwerx, J., & Mangelsdorf, D. J. (2000) · Molecular Cell · doi:10.1016/s1097-2765(00)00050-2 · Cited by 1,487 · see citing works
Smit, J., Schinkel, A. H., Elferink, R. P. J. O., Groen, A. K., Wagenaar, E., van Deemter, L., Mol, C. A. A. M., Ottenhoff, R., van der Lugt, N. M. T., van ROON, M. A., et al. (1993) · Cell · doi:10.1016/0092-8674(93)90380-9 · Cited by 1,443 · see citing works
Peet, D. J., Turley, S. D., Ma, W., Janowski, B. A., Lobaccaro, J. A., Hammer, R. E., & Mangelsdorf, D. J. (1998) · Cell · doi:10.1016/s0092-8674(00)81432-4 · Cited by 1,428 · see citing works
Activation of the Nuclear Receptor LXR by Oxysterols Defines a New Hormone Response Pathway
Lehmann, J. M., Kliewer, S. A., Moore, L. B., Smith-Oliver, T. A., Oliver, B. B., Su, J.-L., Sundseth, S. S., Winegar, D. A., Blanchard, D. E., Spencer, T. A., et al. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.6.3137 · Cited by 1,233 · see citing works
Identification of a nuclear receptor that is activated by farnesol metabolites
Forman, B. M., Goode, E., Chen, J., Oro, A. E., Bradley, D. J., Perlmann, T., Noonan, D. J., Burka, L. T., McMorris, T., Lamph, W. W., et al. (1995) · Cell · doi:10.1016/0092-8674(95)90530-8 · Cited by 1,210 · see citing works
Crystal structure of the ligand-binding domain of the human nuclear receptor RXR-α
Bourguet, W., Ruff, M., Chambon, P., Gronemeyer, H., & Moras, D. (1995) · Nature · doi:10.1038/375377a0 · Cited by 1,177 · see citing works
Efficient in vivo manipulation of mouse genomic sequences at the zygote stage.
Lakso, M., Pichel, J. G., Gorman, J. R., Sauer, B., Okamoto, Y., Lee, E., Alt, F. W., & Westphal, H. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.12.5860 · Cited by 1,125 · see citing works
Structural requirements of ligands for the oxysterol liver X receptors LXRα and LXRβ
Janowski, B. A., Grogan, M. J., Jones, S. A., Wisely, G. B., Kliewer, S. A., Corey, E. J., & Mangelsdorf, D. J. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.1.266 · Cited by 946 · see citing works
The Sister of P-glycoprotein Represents the Canalicular Bile Salt Export Pump of Mammalian Liver
Gerloff, T., Stieger, B., Hagenbuch, B., Madon, J., Landmann, L., Roth, J., Hofmann, A. F., & Meier, P. J. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.16.10046 · Cited by 938 · see citing works
Aoyama, T., Peters, J. M., Iritani, N., Nakajima, T., Furihata, K., Hashimoto, T., & Gonzalez, F. J. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.10.5678 · Cited by 863 · see citing works
Self-citationAtomic structure of progesterone complexed with its receptor
Williams, S. P., & Sigler, P. B. (1998) · Nature · doi:10.1038/30775 · Cited by 659 · see citing works
Gampe, R. T., Montana, V. G., Lambert, M. H., Miller, A. B., Bledsoe, R. K., Milburn, M. V., Kliewer, S. A., Willson, T. M., & Xu, H. E. (2000) · Molecular Cell · doi:10.1016/s1097-2765(00)80448-7 · Cited by 574 · see citing works
Carr, T. P., Andresen, C. J., & Rudel, L. L. (1993) · Clinical Biochemistry · doi:10.1016/0009-9120(93)90015-x · Cited by 561 · see citing works
Seol, W., Choi, H.-S., & Moore, D. D. (1996) · Science · doi:10.1126/science.272.5266.1336 · Cited by 528 · see citing works
Rodrigues, C. M. P., Fan, G., Ma, X., Kren, B. T., & Steer, C. J. (1998) · Journal of Clinical Investigation · doi:10.1172/jci1325 · Cited by 515 · see citing works
Molecular determinants of nuclear receptor-corepressor interactionPreprint
Perissi, V., Staszewski, L. M., McInerney, E. M., Kurokawa, R., Krones, A., Rose, D. W., L., L. M., Milburn, M. V., Glass, C. K., & Rosenfeld, M. G. (1999) · Genes & Development · doi:10.1101/gad.13.24.3198 · Cited by 514 · see citing works
Orphan Nuclear Receptors: Shifting Endocrinology into Reverse
Kliewer, S. A., Lehmann, J. M., & Willson, T. M. (1999) · Science · doi:10.1126/science.284.5415.757 · Cited by 499 · see citing works
Jansen, P. L. M., Strautnieks, S. S., Jacquemin, E., Hadchouel, M., Sokal, E. M., Hooiveld, G. J. E. J., Koning, J. H., de Jager-Krikken, A., Kuipers, F., Stellaard, F., et al. (1999) · Gastroenterology · doi:10.1016/s0016-5085(99)70287-8 · Cited by 434 · see citing works
Alterations in Lipoprotein Metabolism in Peroxisome Proliferator-activated Receptor α-deficient Mice
Peters, J. M., Hennuyer, N., Staels, B., Fruchart, J., Fiévet, C., Gonzalez, F. J., & Auwerx, J. H. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.43.27307 · Cited by 429 · see citing works
Self-citationThe AF1 and AF2 Domains of the Androgen Receptor Interact with Distinct Regions of SRC1
Bevan, C. L., Hoare, S., Claessens, F., Heery, D. M., & Parker, M. G. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.12.8383 · Cited by 424 · see citing works
Mechanisms and regulation of bile secretion
Nathanson, M. H., & Boyer, J. L. (1991) · Hepatology · doi:10.1002/hep.1840140324 · Cited by 406 · see citing works
Seol, W., Choi, H.-S., & Moore, D. D. (1995) · Molecular Endocrinology · doi:10.1210/mend.9.1.7760852 · Cited by 389 · see citing works
Jelinek, D. F., Andersson, S., Slaughter, C. A., & Russell, D. W. (1990) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)39056-8 · Cited by 367 · see citing works
The LXRs: a new class of oxysterol receptors
Peet, D. J., Janowski, B. A., & Mangelsdorf, D. J. (1998) · Current Opinion in Genetics & Development · doi:10.1016/s0959-437x(98)80013-0 · Cited by 362 · see citing works
Identification of a Bile Acid-responsive Element in the Human Ileal Bile Acid-binding Protein Gene
Grober, J., Zaghini, I., Fujii, H., Jones, S. A., Kliewer, S. A., Willson, T. M., Ono, T., & Besnard, P. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.42.29749 · Cited by 353 · see citing works
Lee, Y., Dell, H., Dowhan, D. H., Hadzopoulou‐Cladaras, M., & Moore, D. D. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.1.187-195.2000 · Cited by 307 · see citing works
Orphan nuclear receptors—new ligands and new possibilities: Figure 1.Preprint
Blumberg, B., & Evans, R. M. (1998) · Genes & Development · doi:10.1101/gad.12.20.3149 · Cited by 301 · see citing works
Cloning and characterization of a second member of the mouse mdr gene family.
Gros, P., Raymond, M., Bell, J. C., et al. (1988) · Molecular and Cellular Biology · doi:10.1128/mcb.8.7.2770 · Cited by 267 · see citing works
Biochemistry of bile secretion
COLEMAN, R. (1987) · Biochemical Journal · doi:10.1042/bj2440249 · Cited by 222 · see citing works
Bérard, A. M., Föger, B., Remaley, A. T., Shamburek, R. D., Vaisman, B. L., Talley, G. D., Paigen, B. J., Hoyt, R. F., Marcovina, S. M., Brewer, H. B., et al. (1997) · Nature Medicine · doi:10.1038/nm0797-744 · Cited by 209 · see citing works
Targeted Disruption of the Microsomal Epoxide Hydrolase Gene
Miyata, M., Kudo, G., Lee, Y., et al. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.34.23963 · Cited by 199 · see citing works
Self-citationIdentification of a Locus for Progressive Familial Intrahepatic Cholestasis PFIC2on Chromosome 2q24
Strautnieks, S. S., Kagalwalla, A. F., Tanner, M. S., Knisely, A. S., Bull, L. N., Freimer, N. B., Kocoshis, S. A., Gardiner, R. M., & Thompson, R. J. (1997) · The American Journal of Human Genetics · doi:10.1086/515501 · Cited by 187 · see citing works
Johansson, L., Thomsen, J. S., Damdimopoulos, A. E., Spyrou, G., Gustafsson, J.-Α., & Treuter, E. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.1.345 · Cited by 184 · see citing works
Cathepsin B contributes to bile salt-induced apoptosis of rat hepatocytes
Roberts, L. R., Kurosawa, H., Bronk, S., Fesmier, P. J., Agellon, L. B., Leung, W. Y., Mao, F., & Gores, G. (1997) · Gastroenterology · doi:10.1053/gast.1997.v113.pm9352877 · Cited by 181 · see citing works
Guo, Y.-D., Strugnell, S. A., Back, D. W., et al. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.18.8668 · Cited by 178 · see citing works
REGULATION OF BILE ACID BIOSYNTHESIS
Vlahčevič, Z. R., Pandak, W., & Stravitz, R. T. (1999) · Gastroenterology Clinics of North America · doi:10.1016/s0889-8553(05)70041-8 · Cited by 173 · see citing works
Identification and Characterization of a Mouse Oxysterol 7α-Hydroxylase cDNA
Schwarz, M., Lund, E. G., Lathe, R., Björkhem, I., & Russell, D. W. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.38.23995 · Cited by 157 · see citing works
A Novel Cytochrome P450 Expressed Primarily in Brain
Stapleton, G., Steel, M., Richardson, M., Mason, J. O., Rose, K. A., Morris, R., & Lathe, R. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.50.29739 · Cited by 153 · see citing works
Inhibition of Estrogen Receptor Action by the Orphan Receptor SHP (Short Heterodimer Partner)
Seol, W., Hanstein, B., Brown, M. A., & Moore, D. D. (1998) · Molecular Endocrinology · doi:10.1210/mend.12.10.0184 · Cited by 145 · see citing works
Novel Receptor Interaction and Repression Domains in the Orphan Receptor SHP
Seol, W., Chung, M., & Moore, D. D. (1997) · Molecular and Cellular Biology · doi:10.1128/mcb.17.12.7126 · Cited by 131 · see citing works
Fatty acid binding protein isoforms: structure and function
Schroeder, F., Jolly, C. A., Cho, T., & Frolov, A. (1998) · Chemistry and Physics of Lipids · doi:10.1016/s0009-3084(98)00003-6 · Cited by 130 · see citing works
Molecular cloning and characterization of the murine bile salt export pump
Green, R. M., Hoda, F., & Ward, K. L. (2000) · Gene · doi:10.1016/s0378-1119(99)00460-6 · Cited by 121 · see citing works
Specific Structural Motifs Determine TRAP220 Interactions with Nuclear Hormone Receptors
Ren, Y., Behre, E., Ren, Z., Zhang, J., Wang, Q., & Fondell, J. D. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.15.5433-5446.2000 · Cited by 113 · see citing works
Lambert, G. C., Chase, M. B., Dugi, K. A., Bensadoun, A., Brewer, H. B., & Santamarina-Fojo, S. (1999) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)33491-x · Cited by 113 · see citing works
Self-citationStructural characterisation of the mouse nuclear oxysterol receptor genes LXRα and LXRβ
Alberti, S., Steffensen, K. R., & Gustafsson, J.-Α. (2000) · Gene · doi:10.1016/s0378-1119(99)00555-7 · Cited by 91 · see citing works
Crossman, M. W., Hauft, S. M., & Gordon, J. I. (1994) · The Journal of Cell Biology · doi:10.1083/jcb.126.6.1547 · Cited by 91 · see citing works
Activation of the orphan receptor RIP14 by retinoids
Zavacki, A. M., Lehmann, J. M., Seol, W., Willson, T. M., Kliewer, S. A., & Moore, D. D. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.15.7909 · Cited by 87 · see citing works
von Dippe, P., Amoui, M., Stellwagen, R. H., et al. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.30.18176 · Cited by 84 · see citing works
Bahar, R., & Stolz, A. (1999) · Gastroenterology Clinics of North America · doi:10.1016/s0889-8553(05)70042-x · Cited by 80 · see citing works
Mutations That Alter Ligand-induced Switches and Dimerization Activities in the Retinoid X Receptor
Zhang, X.-K., Salbert, G., Lee, M., & Pfahl, M. (1994) · Molecular and Cellular Biology · doi:10.1128/mcb.14.6.4311 · Cited by 79 · see citing works
Lund, E. G., Björkhem, I., Furster, C., & Wikvall, K. (1993) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/0005-2760(93)90094-p · Cited by 79 · see citing works
Hardikar, W., Ananthanarayanan, M., & Suchy, F. J. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.35.20841 · Cited by 74 · see citing works
Hagenbuch, B., Adler, I. ‐., & Schmid, T. E. (1999) · Biochemical Journal · doi:10.1042/bj3450115 · Cited by 72 · see citing works
Gåfvels, M. E., Olin, M., Chowdhary, B. P., Raudsepp, T., Andersson, U., Persson, B., Jansson, M., Björkhem, I., & Eggertsen, G. (1999) · Genomics · doi:10.1006/geno.1998.5606 · Cited by 72 · see citing works
Intestinal absorption of bile acids in the rabbit: Different transport rates in jejunum and ileum
Aldini, R., Montagnani, M., Roda, A., et al. (1996) · Gastroenterology · doi:10.1053/gast.1996.v110.pm8566593 · Cited by 71 · see citing works
Saeki, T., Matoba, K., Furukawa, H., et al. (1999) · The Journal of Biochemistry · doi:10.1093/oxfordjournals.jbchem.a022358 · Cited by 62 · see citing works
Hepatic lipase deficiency decreases the selective uptake of HDL-cholesteryl esters in vivo
Lambert, G. C., Amar, M. J., Martin, P. G. P., Fruchart‐Najib, J., Föger, B., Shamburek, R. D., Brewer, H. B., & Santamarina-Fojo, S. (2000) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)32375-0 · Cited by 54 · see citing works
Self-citationThyroid Hormone Receptor Variant α2
Yang, Y.-Z., Burgos-Trinidad, M., Wu, Y., & Koenig, R. J. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.45.28235 · Cited by 49 · see citing works
Cattori, V., Eckhardt, U., & Hagenbuch, B. (1999) · Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression · doi:10.1016/s0167-4781(99)00029-9 · Cited by 49 · see citing works
INBORN ERRORS OF BILE ACID BIOSYNTHESIS AND TRANSPORT
Balistreri, W. F. (1999) · Gastroenterology Clinics of North America · doi:10.1016/s0889-8553(05)70048-0 · Cited by 35 · see citing works
Down-regulation of the rat hepatic sterol 27-hydroxylase
Rao, Y.-P., Vlahčevič, Z. R., Stravitz, R. T., Mallonee, D. H., Mullick, J., Avadhani, N. G., & Hylemon, P. B. (1999) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/s0960-0760(99)00099-0 · Cited by 34 · see citing works
Intestinal absorption of bile acids in the pig
Juste, C., Legrand‐Defretin, V., Corring, T., et al. (1988) · Digestive Diseases and Sciences · doi:10.1007/bf01536633 · Cited by 34 · see citing works
Structure of the Mouse Cholesterol 7α-Hydroxylase Gene
Tzung, K., Ishimura‐Oka, K., Kihara, S., et al. (1994) · Genomics · doi:10.1006/geno.1994.1250 · Cited by 33 · see citing works
Hagenbuch, B., Adler, I. ‐., & Schmid, T. E. (2000) · Biochemical Journal · doi:10.1042/0264-6021:3450115 · Cited by 23 · see citing works
Osuga, J.-I., Yonemoto, M., Yamada, N., Shimano, H., Yagyu, H., Ohashi, K., Harada, K., Kamei, T., Yazaki, Y., & Ishibashi, S. (1998) · Journal of Clinical Investigation · doi:10.1172/jci1124 · Cited by 18 · see citing works
Shayiq, R. M., & Avadhani, N. G. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)45896-6 · Cited by 16 · see citing works
Molecular genetics and regulation of bile acid biosynthesis.
Hylemon, P. B., Stravitz, R. T., & Vlahcevic, Z. R. (1994) · PubMed · Cited by 9 · see citing works
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Functional interactions between the gut microbiota and host metabolism
Tremaroli, V., & Bäckhed, F. (2012) · Nature · doi:10.1038/nature11552 · Cited by 4,387 · see citing works
Sayin, S. I., Wahlström, A., Felin, J., Jäntti, S., Marschall, H.-U., Bamberg, K., Angelin, B., Hyötyläinen, T., Orešič, M., & Bäckhed, F. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.01.003 · Cited by 2,331 · see citing works
Bile acid-microbiota crosstalk in gastrointestinal inflammation and carcinogenesis
Jia, W., Xie, G., & Jia, W. (2018) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2017.119 · Cited by 1,924 · see citing works
A regulatory cascade of the nuclear receptors FXR, SHP-1, and LRH-1 represses bile acid biosynthesis
Goodwin, B., Jones, S. A., Price, R. R., Watson, M. A., McKee, D. D., Moore, L. B., Galardi, C., Wilson, J. G., Lewis, M. C., Roth, M. E., et al. (2000) · Molecular Cell · doi:10.1016/s1097-2765(00)00051-4 · Cited by 1,940 · see citing works
Fibroblast growth factor 15 functions as an enterohepatic signal to regulate bile acid homeostasis
Inagaki, T., Choi, M., Moschetta, A., Peng, L., Cummins, C. L., McDonald, J. G., Luo, G., Jones, S. A., Goodwin, B., Richardson, J. A., et al. (2005) · Cell Metabolism · doi:10.1016/j.cmet.2005.09.001 · Cited by 1,865 · see citing works
Role of Bile Acids and Bile Acid Receptors in Metabolic Regulation
Lefebvre, P., Cariou, B., Lien, F., Kuipers, F., & Staels, B. (2009) · Physiological Reviews · doi:10.1152/physrev.00010.2008 · Cited by 1,678 · see citing works
Molecular Basis for Feedback Regulation of Bile Acid Synthesis by Nuclear Receptors
Lu, T. T., Makishima, M., Repa, J. J., Schoonjans, K., Kerr, T. A., Auwerx, J., & Mangelsdorf, D. J. (2000) · Molecular Cell · doi:10.1016/s1097-2765(00)00050-2 · Cited by 1,487 · see citing works
Khovidhunkit, W., Kim, M.-S., Memon, R. A., Shigenaga, J. K., Moser, A. H., Feingold, K. R., & Grunfeld, C. (2004) · Journal of Lipid Research · doi:10.1194/jlr.r300019-jlr200 · Cited by 1,481 · see citing works
The gut-liver axis and the intersection with the microbiome
Tripathi, A., Debelius, J., Brenner, D. A., Karin, M., Loomba, R., Schnabl, B., & Knight, R. (2018) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-018-0011-z · Cited by 1,480 · see citing works
From NASH to HCC: current concepts and future challenges
Anstee, Q. M., Reeves, H. L., Kotsiliti, E., Govaere, O., & Heikenwalder, M. (2019) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-019-0145-7 · Cited by 1,392 · see citing works
Targeting bile‐acid signalling for metabolic diseases
Thomas, C., Pellicciari, R., Pruzanski, M., Auwerx, J., & Schoonjans, K. (2008) · Nature Reviews Drug Discovery · doi:10.1038/nrd2619 · Cited by 1,422 · see citing works
Bile acids and the gut microbiome
Ridlon, J. M., Kang, D. J., Hylemon, P. B., & Bajaj, J. S. (2014) · Current Opinion in Gastroenterology · doi:10.1097/mog.0000000000000057 · Cited by 1,329 · see citing works
Godoy, P., Hewitt, N. J., Albrecht, U., Andersen, M. E., Ansari, N., Bhattacharya, S., Bode, J. G., Bolleyn, J., Borner, C., Böttger, J., et al. (2013) · Archives of Toxicology · doi:10.1007/s00204-013-1078-5 · Cited by 1,280 · see citing works
Pleiotropic Roles of Bile Acids in Metabolism
de Aguiar Vallim, T. Q., Tarling, E. J., & Edwards, P. A. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.03.013 · Cited by 1,209 · see citing works
Bile acids and the gut microbiota: metabolic interactions and impacts on disease
Collins, S. L., Stine, J. G., Bisanz, J. E., Okafor, C. D., & Patterson, A. D. (2023) · Nature Reviews Microbiology · doi:10.1038/s41579-022-00805-x · Cited by 1,214 · see citing works
Regulation of antibacterial defense in the small intestine by the nuclear bile acid receptor
Inagaki, T., Moschetta, A., Lee, Y.-K., Peng, L., Zhao, G., Downes, M., Yu, R. T., Shelton, J. M., Richardson, J. A., Repa, J. J., et al. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0509592103 · Cited by 1,164 · see citing works
The role of the gut microbiota in NAFLD
Leung, C., Rivera, L., Furness, J. B., & Angus, P. W. (2016) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2016.85 · Cited by 1,020 · see citing works
Identification of membrane-type receptor for bile acids (M-BAR)
Maruyama, T., Miyamoto, Y., Nakamura, T., Tamai, Y., Okada, H., Sugiyama, E., Nakamura, T., Itadani, H., & Tanaka, K. (2002) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(02)02550-0 · Cited by 993 · see citing works
Bile salt transporters: molecular characterization, function, and regulation
Trauner, M., & Boyer, J. L. (2003) · Physiological Reviews · doi:10.1152/physrev.00027.2002 · Cited by 999 · see citing works
FXR is a molecular target for the effects of vertical sleeve gastrectomy
Ryan, K. K., Tremaroli, V., Clemmensen, C., Kovatcheva-Datchary, P., Myronovych, A., Karns, R., Wilson-Pérez, H. E., Sandoval, D. A., Kohli, R., Bäckhed, F., et al. (2014) · Nature · doi:10.1038/nature13135 · Cited by 931 · see citing works
Bile acid signaling in metabolic disease and drug therapy
Li, T., & Chiang, J. Y. L. (2014) · Pharmacological Reviews · doi:10.1124/pr.113.008201 · Cited by 935 · see citing works
Kast, H. R., Goodwin, B., Tarr, P. T., Jones, S. A., Anisfeld, A. M., Stoltz, C. M., Tontonoz, P., Kliewer, S., Willson, T. M., & Edwards, P. A. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m109326200 · Cited by 916 · see citing works
Obesity and type 2 diabetes mellitus: connections in epidemiology, pathogenesis, and treatments
Ruze, R., Liu, T., Zou, X., Song, J., Chen, Y., Xu, R., Yin, X., & Xu, Q. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1161521 · Cited by 799 · see citing works
Transcriptional integration of metabolism by the nuclear sterol-activated receptors LXR and FXR
Calkin, A. C., & Tontonoz, P. (2012) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3312 · Cited by 779 · see citing works
Chen, M.-L., Yi, L., Zhang, Y., Zhou, X., Ran, L., Yang, J., Zhu, J.-D., Zhang, Q.-Y., & Mi, M.-T. (2016) · mBio · doi:10.1128/mbio.02210-15 · Cited by 754 · see citing works
“The feedback suppression of CYP7A1 gene transcription by FXR is one of the most important mechanisms in the maintenance of BA homeostasis (30).”
BackgroundJiao, N., Baker, S. S., Chapa-Rodriguez, A., Liu, W., Nugent, C. A., Tsompana, M., Mastrandrea, L., Buck, M. J., Baker, R. D., Genco, R. J., et al. (2018) · Gut · doi:10.1136/gutjnl-2017-314307 · Cited by 737 · see citing works
Intestinal FXR agonism promotes adipose tissue browning and reduces obesity and insulin resistance
Fang, S., Suh, J. M., Reilly, S. M., Yu, E., Osborn, O., Lackey, D., Yoshihara, E., Perino, A., Jacinto, S., Lukasheva, Y., et al. (2015) · Nature Medicine · doi:10.1038/nm.3760 · Cited by 738 · see citing works
Pellicciari, R., Fiorucci, S., Camaioni, E., Clerici, C., Costantino, G., Maloney, P. R., Morelli, A., Parks, D. J., & Willson, T. M. (2002) · Journal of Medicinal Chemistry · doi:10.1021/jm025529g · Cited by 743 · see citing works
Li, F., Jiang, C., Krausz, K. W., Li, Y., Albert, I., Hao, H., Fabre, K. M., Mitchell, J. B., Patterson, A. D., & Gonzalez, F. J. (2013) · Nature Communications · doi:10.1038/ncomms3384 · Cited by 705 · see citing works
Self-citationIntestinal farnesoid X receptor signaling promotes nonalcoholic fatty liver disease
Jiang, C., Xie, C., Li, F., Zhang, L., Nichols, R. G., Krausz, K. W., Cai, J., Qi, Y., Fang, Z.-Z., Takahashi, S., et al. (2015) · Journal of Clinical Investigation · doi:10.1172/jci76738 · Cited by 693 · see citing works
Self-citationThe bile acid receptor FXR is a modulator of intestinal innate immunity
Vavassori, P., Mencarelli, A., Renga, B., Distrutti, E., & Fiorucci, S. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0803978 · Cited by 655 · see citing works
Bile acids and nonalcoholic fatty liver disease: Molecular insights and therapeutic perspectives
Arab, J. P., Karpen, S. J., Dawson, P. A., Arrese, M., & Trauner, M. (2017) · Hepatology · doi:10.1002/hep.28709 · Cited by 634 · see citing works
Farnesoid X receptor antagonizes nuclear factor κB in hepatic inflammatory response
Wang, Y.-D., Chen, W.-D., Wang, M., Yu, D., Forman, B. M., & Huang, W. (2008) · Hepatology · doi:10.1002/hep.22519 · Cited by 639 · see citing works
Recent insights into the pathogenesis of nonalcoholic fatty liver disease
Arab, J. P., Arrese, M., & Trauner, M. (2018) · Annual Review of Pathology Mechanisms of Disease · doi:10.1146/annurev-pathol-020117-043617 · Cited by 573 · see citing works
Hirschfield, G. M., Mason, A., Luketic, V., Lindor, K., Gordon, S. C., Mayo, M., Kowdley, K. V., Vincent, C., Bodhenheimer, H. C., Parés, A., et al. (2015) · Gastroenterology · doi:10.1053/j.gastro.2014.12.005 · Cited by 576 · see citing works
Intestine-selective farnesoid X receptor inhibition improves obesity-related metabolic dysfunction
Jiang, C., Xie, C., Lv, Y., Li, J., Krausz, K. W., Shi, J., Brocker, C. N., Desai, D., Amin, S. G., Bisson, W. H., et al. (2015) · Nature Communications · doi:10.1038/ncomms10166 · Cited by 559 · see citing works
Self-citationOmega-3 fatty acids and coronary heart disease risk: clinical and mechanistic perspectives
Harris, W. S., Miller, M., Tighe, A. P., Davidson, M. H., & Schaefer, E. J. (2008) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2007.11.008 · Cited by 552 · see citing works
Milosevic, I., Vujovic, A., Barac, A., Djelic, M., Korac, M., Radovanovic Spurnic, A., Gmizic, I., Stevanovic, O., Djordjevic, V., Lekic, N., et al. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20020395 · Cited by 551 · see citing works
Gut microbiota mediates intermittent-fasting alleviation of diabetes-induced cognitive impairment
Liu, Z., Dai, X., Zhang, H., Shi, R., Hui, Y., Jin, X., Zhang, W., Wang, L., Wang, Q., Wang, D., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-14676-4 · Cited by 549 · see citing works
The role of the microbiome in NAFLD and NASH
Kolodziejczyk, A. A., Zheng, D., Shibolet, O., & Elinav, E. (2019) · EMBO Molecular Medicine · doi:10.15252/emmm.201809302 · Cited by 523 · see citing works
Bile Acid Transporters: Structure, Function, Regulation and Pathophysiological Implications
Alrefai, W. A., & Gill, R. K. (2007) · Pharmaceutical Research · doi:10.1007/s11095-007-9289-1 · Cited by 500 · see citing works
Bile Acids Induce Inflammatory Genes in Hepatocytes
Allen, K., Jaeschke, H., & Copple, B. L. (2011) · The American Journal of Pathology · doi:10.1016/j.ajpath.2010.11.026 · Cited by 501 · see citing works
Yang, F., Huang, X., Yi, T., Yen, Y., Moore, D. D., & Huang, W. (2007) · Cancer Research · doi:10.1158/0008-5472.can-06-1078 · Cited by 488 · see citing works
Microbiota-gut-brain axis: Modulator of host metabolism and appetite
van de Wouw, M., Schellekens, H., Dinan, T. G., & Cryan, J. F. (2017) · The Journal of Nutrition · doi:10.3945/jn.116.240481 · Cited by 461 · see citing works
Bile acid nuclear receptor FXR and digestive system diseases
Ding, L., Yang, L., Wang, Z., & Huang, W. (2015) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2015.01.004 · Cited by 477 · see citing works
Fiorucci, S., Antonelli, E., Rizzo, G., Renga, B., Mencarelli, A., Riccardi, L., Orlandi, S., Pellicciari, R., & Morelli, A. (2004) · Gastroenterology · doi:10.1053/j.gastro.2004.08.001 · Cited by 472 · see citing works
Molecular physiology of bile acid signaling in health, disease, and aging
Perino, A., Demagny, H., Velazquez-Villegas, L., & Schoonjans, K. (2021) · Physiological Reviews · doi:10.1152/physrev.00049.2019 · Cited by 481 · see citing works
The bile acid TGR5 membrane receptor: from basic research to clinical application
Duboc, H., Taché, Y., & Hofmann, A. F. (2014) · Digestive and Liver Disease · doi:10.1016/j.dld.2013.10.021 · Cited by 473 · see citing works
Kong, B., Wang, L., Chiang, J. Y. L., Zhang, Y., Klaassen, C. D., & Guo, G. L. (2012) · Hepatology · doi:10.1002/hep.25740 · Cited by 456 · see citing works
Bile Acids as Hormones: The FXR-FGF15/19 Pathway
Kliewer, S. A., & Mangelsdorf, D. J. (2015) · Digestive Diseases · doi:10.1159/000371670 · Cited by 424 · see citing works
Kim, Y. D., Park, K.-G., Lee, Y.-S., Park, Y.-Y., Kim, D.-K., Nedumaran, B., Jang, W. G., Cho, W.-J., Ha, J., Lee, I.-K., et al. (2008) · Diabetes · doi:10.2337/db07-0381 · Cited by 422 · see citing works
FXR: a metabolic regulator and cell protector
Wang, Y.-D., Chen, W.-D., Moore, D. D., & Huang, W. (2008) · Cell Research · doi:10.1038/cr.2008.289 · Cited by 389 · see citing works
Spontaneous hepatocarcinogenesis in farnesoid X receptor-null mice
Kim, I., Morimura, K., Shah, Y., Yang, Q., Ward, J. M., & Gonzalez, F. J. (2007) · Carcinogenesis · doi:10.1093/carcin/bgl249 · Cited by 357 · see citing works
Self-citationFunction of retinoic acid receptors during embryonic development
Mark, M., Ghyselinck, N. B., & Chambon, P. (2009) · Nuclear Receptor Signaling · doi:10.1621/nrs.07002 · Cited by 363 · see citing works
Degirolamo, C., Rainaldi, S., Bovenga, F., Murzilli, S., & Moschetta, A. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.02.032 · Cited by 356 · see citing works
FXR, a multipurpose nuclear receptor
Lee, F. Y., Lee, H., Hubbert, M. L., Edwards, P. A., & Zhang, Y. (2006) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2006.08.002 · Cited by 344 · see citing works
Kemper, J. K., Xiao, Z., Ponugoti, B., Miao, J., Fang, S., Kanamaluru, D., Tsang, S., Wu, S.-Y., Chiang, C.-M., & Veenstra, T. D. (2009) · Cell Metabolism · doi:10.1016/j.cmet.2009.09.009 · Cited by 332 · see citing works
Mining the microbiota for microbial and metabolite-based immunotherapies
Skelly, A. N., Sato, Y., Kearney, S., & Honda, K. (2019) · Nature Reviews Immunology · doi:10.1038/s41577-019-0144-5 · Cited by 306 · see citing works
Ghonem, N. S., Assis, D. N., & Boyer, J. L. (2015) · Hepatology · doi:10.1002/hep.27744 · Cited by 317 · see citing works
Guo, G. L., Lambert, G., Negishi, M., Ward, J. M., Brewer, H. B., Kliewer, S. A., Gonzalez, F. J., & Sinal, C. J. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m307145200 · Cited by 312 · see citing works
Self-citationMutations in the nuclear bile acid receptor FXR cause progressive familial intrahepatic cholestasis
Gomez-Ospina, N., Potter, C. J., Xiao, R., Manickam, K., Kim, M.-S., Kim, K. H., Shneider, B. L., Picarsic, J. L., Jacobson, T. A., Zhang, J., et al. (2016) · Nature Communications · doi:10.1038/ncomms10713 · Cited by 300 · see citing works
Zhang, S., Wang, J., Liu, Q., & Harnish, D. C. (2009) · Journal of Hepatology · doi:10.1016/j.jhep.2009.03.025 · Cited by 290 · see citing works
Inter-organ cross-talk in metabolic syndrome
Priest, C., & Tontonoz, P. (2019) · Nature Metabolism · doi:10.1038/s42255-019-0145-5 · Cited by 279 · see citing works
Modica, S., Petruzzelli, M., Bellafante, E., Murzilli, S., Salvatore, L., Celli, N., Di Tullio, G., Palasciano, G., Moustafa, T., Halilbasic, E., et al. (2012) · Gastroenterology · doi:10.1053/j.gastro.2011.10.028 · Cited by 275 · see citing works
A selective gut bacterial bile salt hydrolase alters host metabolism
Yao, L., Seaton, S. C., Ndousse-Fetter, S., Adhikari, A. A., DiBenedetto, N., Mina, A. I., Banks, A. S., Bry, L., & Devlin, A. S. (2018) · eLife · doi:10.7554/elife.37182 · Cited by 274 · see citing works
Coordinate transcriptional regulation of bile acid homeostasis and drug metabolism
Eloranta, J. J., & Kullak-Ublick, G. A. (2005) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2004.09.019 · Cited by 260 · see citing works
Trimethylamine-N-oxide (TMAO)-induced atherosclerosis is associated with bile acid metabolism
Ding, L., Chang, M., Guo, Y., Zhang, L., Xue, C., Yanagita, T., Zhang, T., & Wang, Y. (2018) · Lipids in Health and Disease · doi:10.1186/s12944-018-0939-6 · Cited by 250 · see citing works
Non-alcoholic fatty liver and the gut microbiota
Bashiardes, S., Shapiro, H., Rozin, S., Shibolet, O., & Elinav, E. (2016) · Molecular Metabolism · doi:10.1016/j.molmet.2016.06.003 · Cited by 241 · see citing works
Cholic acid mediates negative feedback regulation of bile acid synthesis in mice
Li-Hawkins, J., Gåfvels, M., Olin, M., Lund, E. G., Andersson, U., Schuster, G., Björkhem, I., Russell, D. W., & Eggertsen, G. (2002) · Journal of Clinical Investigation · doi:10.1172/jci0216309 · Cited by 227 · see citing works
Corona, G., Mannucci, E., Forti, G., & Maggi, M. (2009) · International Journal of Andrology · doi:10.1111/j.1365-2605.2008.00951.x · Cited by 223 · see citing works
Intestinal absorption of bile acids in health and disease
Ticho, A. L., Malhotra, P., Dudeja, P. K., Gill, R. K., & Alrefai, W. A. (2019) · Comprehensive physiology · doi:10.1002/cphy.c190007 · Cited by 215 · see citing works
Novel therapeutic targets for cholestatic and fatty liver disease
Trauner, M., & Fuchs, C. D. (2022) · Gut · doi:10.1136/gutjnl-2021-324305 · Cited by 204 · see citing works
Sun, R., Yang, N., Kong, B., Cao, B., Feng, D., Yu, X., Ge, C., Huang, J., Shen, J., Wang, P., et al. (2017) · Molecular Pharmacology · doi:10.1124/mol.116.106617 · Cited by 199 · see citing works
Prieur, X., Coste, H., & Rodríguez, J. C. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m301302200 · Cited by 194 · see citing works
Molecular basis of bile acid-FXR-FGF15/19 signaling axis
Katafuchi, T., & Makishima, M. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23116046 · Cited by 193 · see citing works
Nuclear receptors in bile acid metabolism
Li, T., & Chiang, J. Y. L. (2013) · Drug Metabolism Reviews · doi:10.3109/03602532.2012.740048 · Cited by 176 · see citing works
Xu, Y., Li, F., Zalzala, M., Xu, J., Gonzalez, F. J., Adorini, L., Lee, Y., Yin, L., & Zhang, Y. (2016) · Hepatology · doi:10.1002/hep.28712 · Cited by 172 · see citing works
Self-citationFickert, P., Fuchsbichler, A., Moustafa, T., Wagner, M., Zollner, G., Halilbasic, E., Stöger, U., Arrese, M., Pizarro, M., Solís, N., et al. (2009) · The American Journal of Pathology · doi:10.2353/ajpath.2009.090114 · Cited by 169 · see citing works
SUMOylation inhibitors synergize with FXR agonists in combating liver fibrosis
Zhou, J., Cui, S., He, Q., Guo, Y., Pan, X., Zhang, P., Huang, N., Ge, C., Wang, G., Gonzalez, F. J., et al. (2020) · Nature Communications · doi:10.1038/s41467-019-14138-6 · Cited by 154 · see citing works
Self-citationBile acids and bariatric surgery
Albaugh, V. L., Banan, B., Ajouz, H., Abumrad, N. N., & Flynn, C. R. (2017) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2017.04.001 · Cited by 148 · see citing works
Nuclear receptors as therapeutic targets in cholestatic liver diseases
Zollner, G., & Trauner, M. (2009) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2008.00030.x · Cited by 146 · see citing works
Non-alcoholic Fatty Liver Disease and Alcohol-Related Liver Disease: Two Intertwined Entities
Idalsoaga, F., Kulkarni, A. V., Mousa, O. Y., Arrese, M., & Arab, J. P. (2020) · Frontiers in Medicine · doi:10.3389/fmed.2020.00448 · Cited by 136 · see citing works
How bile acids and the microbiota interact to shape host immunity
Lee, M. H., Nuccio, S.-P., Mohanty, I., Hagey, L. R., Dorrestein, P. C., Chu, H., & Raffatellu, M. (2024) · Nature Reviews Immunology · doi:10.1038/s41577-024-01057-x · Cited by 143 · see citing works
Degirolamo, C., Modica, S., Vacca, M., Di Tullio, G., Morgano, A., D'Orazio, A., Kannisto, K., Parini, P., & Moschetta, A. (2015) · Hepatology · doi:10.1002/hep.27274 · Cited by 121 · see citing works
Chen, W., Owsley, E., Yang, Y., Stroup, D., & Chiang, J. Y. L. (2001) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)30272-8 · Cited by 112 · see citing works
Identification of Novel Pathways That Control Farnesoid X Receptor-mediated Hypocholesterolemia
Zhang, Y., Yin, L., Anderson, J., Ma, H., Gonzalez, F. J., Willson, T. M., & Edwards, P. A. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.083899 · Cited by 112 · see citing works
Self-citationDeletion of mouse FXR gene disturbs multiple neurotransmitter systems and alters neurobehavior
Huang, F., Wang, T., Lan, Y., Yang, L., Pan, W., Zhu, Y., Lv, B., Wei, Y., Shi, H., Wu, H., et al. (2015) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2015.00070 · Cited by 109 · see citing works
Role of TGR5 (GPBAR1) in Liver Disease
Häussinger, D., & Keitel, V. (2018) · Seminars in Liver Disease · doi:10.1055/s-0038-1669940 · Cited by 106 · see citing works
Liu, X., El-Mahdy, M. A., Boslett, J., Varadharaj, S., Hemann, C., Abdelghany, T. M., Ismail, R. S., Little, S. C., Zhou, D., Thuy, L. T. T., et al. (2017) · Nature Communications · doi:10.1038/ncomms14807 · Cited by 105 · see citing works
Hepatic FXR/SHP axis modulates systemic glucose and fatty acid homeostasis in aged mice
Kim, K. H., Choi, S., Zhou, Y., Kim, E. Y., Lee, J. M., Saha, P. K., Anakk, S., & Moore, D. D. (2017) · Hepatology · doi:10.1002/hep.29199 · Cited by 107 · see citing works
Akiyama, T. E., Lambert, G., Nicol, C. J., Matsusue, K., Peters, J. M., Brewer, H. B., & Gonzalez, F. J. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m312802200 · Cited by 97 · see citing works
Self-citationNuclear receptors linking metabolism, inflammation, and fibrosis in nonalcoholic fatty liver disease
Puengel, T., Liu, H., Guillot, A., Heymann, F., Tacke, F., & Peiseler, M. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23052668 · Cited by 95 · see citing works
Kim, T., Nason, S., Holleman, C., Pepin, M., Wilson, L., Berryhill, T. F., Wende, A. R., Steele, C., Young, M. E., Barnes, S., et al. (2018) · Diabetes · doi:10.2337/db17-1502 · Cited by 97 · see citing works
Bile acids: From digestion to cancers
Baptissart, M., Vega, A., Maqdasy, S., Caira, F., Baron, S., Lobaccaro, J.-M. A., & Volle, D. H. (2013) · Biochimie · doi:10.1016/j.biochi.2012.06.022 · Cited by 97 · see citing works
Gai, Z., Visentin, M., Gui, T., Zhao, L., Thasler, W. E., Häusler, S., Hartling, I., Cremonesi, A., Hiller, C., & Kullak-Ublick, G. A. (2018) · Molecular Pharmacology · doi:10.1124/mol.117.111047 · Cited by 91 · see citing works
Purushotham, A., Xu, Q., Lu, J., Foley, J. F., Yan, X., Kim, D.-H., Kemper, J. K., & Li, X. (2012) · Molecular and Cellular Biology · doi:10.1128/mcb.05988-11 · Cited by 87 · see citing works
Nonsteroidal FXR Ligands: Current Status and Clinical Applications
Gege, C., Hambruch, E., Hambruch, N., Kinzel, O., & Kremoser, C. (2019) · Handbook of Experimental Pharmacology · doi:10.1007/164_2019_232 · Cited by 83 · see citing works
Roles of microRNA-29a in the antifibrotic effect of farnesoid X receptor in hepatic stellate cells
Li, J., Zhang, Y., Kuruba, R., Gao, X., Gandhi, C. R., Xie, W., & Li, S. (2011) · Molecular Pharmacology · doi:10.1124/mol.110.068247 · Cited by 78 · see citing works
Role of bile acids in the regulation of the metabolic pathways
Taoka, H., Yokoyama, Y., Morimoto, K., Kitamura, N., Tanigaki, T., Takashina, Y., Tsubota, K., & Watanabe, M. (2016) · World Journal of Diabetes · doi:10.4239/wjd.v7.i13.260 · Cited by 80 · see citing works
Miyata, M., Sakaida, Y., Matsuzawa, H., Yoshinari, K., & Yamazoe, Y. (2011) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.34.1885 · Cited by 77 · see citing works
Self-citation
- Authors
- Sinal, C. J., Tohkin, M., Miyata, M., Ward, J. M., Lambert, G., & Gonzalez, F. J.
- Affiliations
- National Institutes of Health (US)
- Corresponding author
- Gonzalez, Frank J
- ORCID
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2000-09
- Volume
- 102
- Issue
- 6
- Pages
- 731-744
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2051040521
- Cited by
- 1,819
- References
- 76
- Citations by year
- 2026: 46 · 2025: 63 · 2024: 75 · 2023: 83 · 2022: 89 · 2021: 83 · 2020: 81 · 2019: 77 · 2018: 79 · 2017: 83 · 2016: 69 · 2015: 61 · 2014: 68 · 2013: 69 · 2012: 74
- FWCI
- 27.89
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
- Health Sciences › Medicine › Surgery › Cholesterol and Lipid Metabolism
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
- Keywords
- farnesoid X receptor, bile acid homeostasis, lipid homeostasis, CYP7A1, ileal bile acid binding protein, bile acid transport, fecal bile acid excretion, liver cholesterol, serum lipoproteins, atherosclerosis, knockout mice
- MeSH terms
- Receptor, Farnesoid X-Activated, Animals, Bile Acids and Salts, Biological Transport, Cholesterol 7-alpha-Hydroxylase, Cholesterol, Dietary, DNA-Binding Proteins, Female, Homeostasis, Liver, Male, RNA, Messenger, Transcription Factors, Triglycerides, Gene Expression, Receptors, Cytoplasmic and Nuclear, Mice, Knockout, Mice
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