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Components of the ribosome biogenesis pathway underlie establishment of telomere length set point in Arabidopsis

Abdulkina, Liliia R., Kobayashi, Callie, Lovell, John T., Chastukhina, Inna B., Aklilu, Behailu B., Agabekian, Inna A., Suescún, Ana V., Valeeva, Lia R., Nyamsuren, Chuluuntsetseg, Aglyamova, Galina V., Sharipova, Margarita R., Shippen, Dorothy E., Juenger, Thomas E., Shakirov, Eugene V.·2019·Nature Communications
DOI 10.1038/s41467-019-13448-zPMC PMC6889149
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Abstract

Telomeres cap the physical ends of eukaryotic chromosomes to ensure complete DNA replication and genome stability. Heritable natural variation in telomere length exists in yeast, mice, plants and humans at birth; however, major effect loci underlying such polymorphism remain elusive. Here, we employ quantitative trait locus (QTL) mapping and transgenic manipulations to identify genes controlling telomere length set point in a multi-parent Arabidopsis thaliana mapping population. We detect several QTL explaining 63.7% of the total telomere length variation in the Arabidopsis MAGIC population. Loss-of-function mutants of the NOP2A candidate gene located inside the largest effect QTL and of two other ribosomal genes RPL5A and RPL5B establish a shorter telomere length set point than wild type. These findings indicate that evolutionarily conserved components of ribosome biogenesis and cell proliferation pathways promote telomere elongation.

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  • Private allelic contributions in multi-parent populations offer a powerful opportunity to define high-confidence candidates as genes with parent-specific sequences that match parent-specific allelic contributions to phenotypic trait variation.

    “Such ‘private’ allelic contributions in multi-parent populations offer a powerful opportunity to define high-confidence candidates as genes with parent-specific sequences that match parent-specific allelic contributions to phenotypic trait variation (Abdulkina et al., 2019).”

    From GENESPACE tracks regions of interest and gene copy number variation across multiple genomes (2022) · cites this paper as Abdulkina et al., 2019

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Metadata

Authors
Abdulkina, L. R., Kobayashi, C., Lovell, J. T., Chastukhina, I. B., Aklilu, B. B., Agabekian, I. A., Suescún, A. V., Valeeva, L. R., Nyamsuren, C., Aglyamova, G. V., Sharipova, M. R., Shippen, D. E., Juenger, T. E., & Shakirov, E. V.
ORCID
Venue
Nature Communications
Publisher
Springer Science and Business Media LLC
Published
2019-12-02
Volume
10
Issue
1
ISSN
2041-1723
DOI
10.1038/s41467-019-13448-z
PMC
PMC6889149
Cited by
27
References
3
Language
en
Licence
Funders
  • Russian Foundation for Basic Research (18-34-00629)
  • U.S. Department of Health & Human Services | National Institutes of Health (R01 GM065383, R01 GM127402, R03 AG052891)
  • National Science Foundation (IOS-0922457)

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