The DOI matches its Crossref record; 96 of the 96 references it cites were found in a registry or an index.
A unified connectomic target for deep brain stimulation in obsessive-compulsive disorder
Open accessAbstract
Multiple surgical targets for treating obsessive-compulsive disorder with deep brain stimulation (DBS) have been proposed. However, different targets may modulate the same neural network responsible for clinical improvement. We analyzed data from four cohorts of patients ( N = 50) that underwent DBS to the anterior limb of the internal capsule (ALIC), the nucleus accumbens or the subthalamic nucleus (STN). The same fiber bundle was associated with optimal clinical response in cohorts targeting either structure. This bundle connected frontal regions to the STN. When informing the tract target based on the first cohort, clinical improvements in the second could be significantly predicted, and vice versa. To further confirm results, clinical improvements in eight patients from a third center and six patients from a fourth center were significantly predicted based on their stimulation overlap with this tract. Our results show that connectivity-derived models may inform clinical improvements across DBS targets, surgeons and centers. The identified tract target is openly available in atlas form.
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Self-citationA Randomized Trial of Deep-Brain Stimulation for Parkinson's Disease
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Opportunities of connectomic neuromodulation
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Self-citationRevisiting the global workspace orchestrating the hierarchical organization of the human brain
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Gadot, R., Najera, R., Hirani, S., Anand, A., Storch, E., Goodman, W. K., Shofty, B., & Sheth, S. A. (2022) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp-2021-328738 · Cited by 148
Prefrontal connectomics: From anatomy to human imaging
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Metadata
- Authors
- Li, N., Baldermann, J. C., Kibleur, A., Treu, S., Akram, H., Elias, G. J. B., Boutet, A., Lozano, A. M., Al-Fatly, B., Strange, B., Barcia, J. A., Zrinzo, L., Joyce, E., Chabardes, S., Visser-Vandewalle, V., Polosan, M., Kuhn, J., Kühn, A. A., & Horn, A.
- Venue
- Nature Communications
- Published
- 2020-07-03
- Volume
- 11
- Issue
- 1
- Pages
- 3364-3364
- ISSN
- 2041-1723 (ISSN-L)
- OpenAlex
- W3040235203
- Cited by
- 316
- References
- 96
- FWCI
- 19.20
- Type
- journal article
- Language
- en
- Open access
- gold
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- Li, N., Baldermann, J. C., Kibleur, A., Treu, S., Akram, H., Elias, G. J. B., Boutet, A., Lozano, A. M., Al-Fatly, B., Strange, B., Barcia, J. A., Zrinzo, L., Joyce, E., Chabardes, S., Visser-Vandewalle, V., Polosan, M., Kuhn, J., Kühn, A. A., & Horn, A. (2020). A unified connectomic target for deep brain stimulation in obsessive-compulsive disorder. Nature Communications. https://doi.org/10.1038/s41467-020-16734-3
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
