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Cited by 94Sodium Intake and HealthBlood Pressure and Hypertension StudiesElectrolyte and hormonal disorders

Tissue sodium excess is not hypertonic and reflects extracellular volume expansion

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Rossitto, Giacomo, Mary, Sheon, Chen, Jun Yu, Boder, Philipp, Chew, Khai Syuen, Neves, Karla B., Alves, Rheure L., Montezano, Augusto C. +5 more·2020·Nature Communications
DOI 10.1038/s41467-020-17820-2PMC PMC7445299
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Abstract

Abstract Our understanding of Na+ homeostasis has recently been reshaped by the notion of skin as a depot for Na+ accumulation in multiple cardiovascular diseases and risk factors. The proposed water-independent nature of tissue Na+ could induce local pathogenic changes, but lacks firm demonstration. Here, we show that tissue Na+ excess upon high Na+ intake is a systemic, rather than skin-specific, phenomenon reflecting architectural changes, i.e. a shift in the extracellular-to-intracellular compartments, due to a reduction of the intracellular or accumulation of water-paralleled Na+ in the extracellular space. We also demonstrate that this accumulation is unlikely to justify the observed development of experimental hypertension if it were water-independent. Finally, we show that this isotonic skin Na+ excess, reflecting subclinical oedema, occurs in hypertensive patients and in association with aging. The implications of our findings, questioning previous assumptions but also reinforcing the importance of tissue Na+ excess, are both mechanistic and clinical.

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  • Altered lymphatic function contributes to subclinical edema that can compromise organ function in conditions including heart failure with preserved ejection fraction and diseases associated with excess tissue sodium storage.

    “Recent studies suggest that altered lymphatic function contributes to subclinical edema that can compromise organ function under conditions that include heart failure with preserved ejection fraction (132) and diseases associated with excess tissue sodium storage (133).”

    From Transport and Immune Functions of the Lymphatic System. (2025) · cites this paper as [133]

    The Discussion (page unavailable) links lymphatic network plasticity to fluid homeostasis and identifies subclinical oedema as a potential influence on organ function. The paper also reports that excess tissue sodium reflects subclinical oedema, but it does not establish that altered lymphatic function causes that oedema. The heart-failure-with-preserved-ejection-fraction example is attached to a different citation, not this source. (LLM, conf=0.83)

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References 47 · Cited by 94

Research works printed but not linked: 36

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Authors
Rossitto, G., Mary, S., Chen, J. Y., Boder, P., Chew, K. S., Neves, K. B., Alves, R. L., Montezano, A. C., Welsh, P., Petrie, M. C., Graham, D., Touyz, R. M., & Delles, C.
Affiliations
University of Glasgow (GB)
Corresponding author
Rossitto, Giacomo
ORCID
Venue
Nature Communications
Publisher
Springer Science and Business Media LLC
Published
2020-08-24
Volume
11
Issue
1
Pages
4222-4222
ISSN
2041-1723 (ISSN-L)
DOI
10.1038/s41467-020-17820-2
PMC
PMC7445299
OpenAlex
W3080577993
Cited by
94
References
47
Citations by year
2026: 7 · 2025: 15 · 2024: 10 · 2023: 20 · 2022: 20 · 2021: 17 · 2020: 4
FWCI
9.64
Type
journal article
Language
en
Open access
Licence
Locations
  • Nature Communications (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • ENLIGHTEN (Jurnal Bimbingan dan Konseling Islam) (acceptedVersion, cc-by-sa)
  • Strathprints: The University of Strathclyde institutional repository (University of Strathclyde) (submittedVersion)
  • RePEc: Research Papers in Economics (submittedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • Padua Research Archive (University of Padova) (submittedVersion, cc-by)
Funders
  • British Heart Foundation (RE/18/6/34217, RE/13/5/30177, CH/4/29762)
  • Academy of Medical Sciences (NIF004\1010)
  • University of Glasgow
Topics
  • Health Sciences › Nursing › Nutrition and Dietetics › Sodium Intake and Health
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Electrolyte and hormonal disorders
Keywords
extracellular volume expansion, sodium homeostasis, hypertonicity, experimental hypertension, aging, high sodium intake, extracellular space
MeSH terms
Aging, Animals, Edema, Female, Homeostasis, Humans, Hypertension, Liver, Lung, Male, Myocardium, Organ Specificity, Osmolar Concentration, Potassium, Rats, Inbred WKY, Skin, Sodium, Transcription Factors, Water-Electrolyte Balance

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