The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.
Single-cell analysis of developing and azoospermia human testicles reveals central role of Sertoli cells
Open accessAbstract
Clinical efficacy of treatments against non-obstructive azoospermia (NOA), which affects 1% of men, are currently limited by the incomplete understanding of NOA pathogenesis and normal spermatogenic microenvironment. Here, we profile >80,000 human testicular single-cell transcriptomes from 10 healthy donors spanning the range from infant to adult and 7 NOA patients. We show that Sertoli cells, which form the scaffold in the testicular microenvironment, are severely damaged in NOA patients and identify the roadmap of Sertoli cell maturation. Notably, Sertoli cells of patients with congenital causes (Klinefelter syndrome and Y chromosome microdeletions) are mature, but exhibit abnormal immune responses, while the cells in idiopathic NOA (iNOA) are physiologically immature. Furthermore, we find that inhibition of Wnt signaling promotes the maturation of Sertoli cells from iNOA patients, allowing these cells to regain their ability to support germ cell survival. We provide a novel perspective on the development of diagnostic methods and therapeutic targets for NOA.
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Cites
Single-cell reconstruction of the early maternal–fetal interface in humans
Vento-Tormo, R., Efremova, M., Botting, R. A., Turco, M. Y., Vento-Tormo, M., Meyer, K. B., Park, J.-E., Stephenson, E., Polański, K., Goncalves, A., et al. (2018) · Nature · doi:10.1038/s41586-018-0698-6 · Cited by 2,358
X-inactivation profile reveals extensive variability in X-linked gene expression in females
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A single-cell resolution map of mouse hematopoietic stem and progenitor cell differentiation
Nestorowa, S., Hamey, F. K., Pijuan Sala, B., Diamanti, E., Shepherd, M., Laurenti, E., Wilson, N. K., Kent, D. G., & Göttgens, B. (2016) · Blood · doi:10.1182/blood-2016-05-716480 · Cited by 768
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Single-cell RNA-seq uncovers dynamic processes and critical regulators in mouse spermatogenesis
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The Neonatal and Adult Human Testis Defined at the Single-Cell Level
Sohni, A., Tan, K., Song, H.-W., Burow, D., de Rooij, D. G., Laurent, L., Hsieh, T.-C., Rabah, R., Hammoud, S. S., Vicini, E., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.01.045 · Cited by 339
The Dynamic Transcriptional Cell Atlas of Testis Development during Human Puberty
Guo, J., Nie, X., Giebler, M., Mlcochova, H., Wang, Y., Grow, E. J., Kim, R., Tharmalingam, M., Matilionyte, G., Lindskog, C., et al. (2020) · Cell Stem Cell · doi:10.1016/j.stem.2019.12.005 · Cited by 315
Metadata
- Authors
- Zhao, L., Yao, C., Xing, X., Jing, T., Li, P., Zhu, Z., Yang, C., Zhai, J., Tian, R., Chen, H., Luo, J., Liu, N., Deng, Z., Lin, X., Li, N., Fang, J., Sun, J., Wang, C., Zhou, Z., & Li, Z.
- Venue
- Nature Communications
- Published
- 2020-11-10
- Volume
- 11
- Issue
- 1
- Pages
- 5683-5683
- ISSN
- 2041-1723 (ISSN-L)
- OpenAlex
- W3102016493
- Cited by
- 298
- References
- 30
- FWCI
- 20.98
- Type
- journal article
- Language
- en
- Open access
- gold
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- Zhao, L., Yao, C., Xing, X., Jing, T., Li, P., Zhu, Z., Yang, C., Zhai, J., Tian, R., Chen, H., Luo, J., Liu, N., Deng, Z., Lin, X., Li, N., Fang, J., Sun, J., Wang, C., Zhou, Z., & Li, Z. (2020). Single-cell analysis of developing and azoospermia human testicles reveals central role of Sertoli cells. Nature Communications. https://doi.org/10.1038/s41467-020-19414-4
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
