Smc5/6 functions with Sgs1-Top3-Rmi1 to complete chromosome replication at natural pause sites
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Smc5/6 is essential for genome structural integrity by yet unknown mechanisms. Here we find that Smc5/6 co-localizes with the DNA crossed-strand processing complex Sgs1-Top3-Rmi1 (STR) at genomic regions known as natural pausing sites (NPSs) where it facilitates Top3 retention. Individual depletions of STR subunits and Smc5/6 cause similar accumulation of joint molecules (JMs) composed of reversed forks, double Holliday Junctions and hemicatenanes, indicative of Smc5/6 regulating Sgs1 and Top3 DNA processing activities. We isolate an intra-allelic suppressor of smc6-56 proficient in Top3 retention but affected in pathways that act complementarily with Sgs1 and Top3 to resolve JMs arising at replication termination. Upon replication stress, the smc6-56 suppressor requires STR and Mus81-Mms4 functions for recovery, but not Srs2 and Mph1 helicases that prevent maturation of recombination intermediates. Thus, Smc5/6 functions jointly with Top3 and STR to mediate replication completion and influences the function of other DNA crossed-strand processing enzymes at NPSs.
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The model of the Siz2 and Mms21 SUMO ligase complex suggests that both E3s could act jointly to modify DNA associated substrates perhaps through the DNA binding SAP domain of Siz2 or involving the Mms21 (Nse2) containing Smc5-6 complex.
“Our model of the Siz2 and Mms21 SUMO ligase complex (fig. S21A) suggests that both E3s could act jointly to modify DNA associated substrates perhaps through the DNA binding SAP domain of Siz2 (53) or involving the Mms21 (Nse2) containing Smc5–6 complex which modulates DNA recombination, replication and repair (54,55).”
From Computed structures of core eukaryotic protein complexes (2021) · cites this paper as [55]
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Allelic Analysis of smc-6 Reveals Domain-Specific Roles in DNA Repair in Caenorhabditis elegans
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The Multifunctional SMC5/6 Complex in Genome Stability, Antiviral Restriction, and Human Disease
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- Authors
- Agashe, S., Joseph, C. R., Reyes, T. A. C., Menolfi, D., Giannattasio, M., Waizenegger, A., Szakal, B., & Branzei, D.
- Affiliations
- IFOM (IT)
- University of Milan (IT)
- Corresponding author
- Branzei, Dana
- ORCID
- Venue
- Nature Communications
- Published
- 2021-04-08
- Volume
- 12
- Issue
- 1
- Pages
- 2111-2111
- ISSN
- 2041-1723 (ISSN-L)
- PMC
- PMC8032827
- OpenAlex
- W3150177260
- Cited by
- 25
- References
- 70
- Citations by year
- 2026: 6 · 2025: 1 · 2024: 6 · 2023: 6 · 2022: 4 · 2021: 2
- FWCI
- 1.41
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Nature Communications (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Archivio Istituzionale della Ricerca (Universita Degli Studi Di Milano) (submittedVersion, other-oa)
- Universitätsbibliographie, Universität Duisburg-Essen (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Associazione Italiana per la Ricerca sul Cancro (23710, 682190, IG 23710, 18976)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
- Keywords
- joint molecules, Holliday junction, replication termination, replication stress, Mus81-Mms4, Srs2
- MeSH terms
- DNA Repair, DNA Replication, DNA-Binding Proteins, Endonucleases, Saccharomyces cerevisiae, Genome, Fungal, Cell Cycle Proteins, Saccharomyces cerevisiae Proteins, Flap Endonucleases, RecQ Helicases
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