The DOI matches its Crossref record; 46 of the 46 references it cites were found in a registry or an index.
Long-lasting renewable antibacterial porous polymeric coatings enable titanium biomaterials to prevent and treat peri-implant infection
Open accessAbstract
Peri-implant infection is one of the biggest threats to the success of dental implant. Existing coatings on titanium surfaces exhibit rapid decrease in antibacterial efficacy, which is difficult to promisingly prevent peri-implant infection. Herein, we report an N-halamine polymeric coating on titanium surface that simultaneously has long-lasting renewable antibacterial efficacy with good stability and biocompatibility. Our coating is powerfully biocidal against both main pathogenic bacteria of peri-implant infection and complex bacteria from peri-implantitis patients. More importantly, its antibacterial efficacy can persist for a long term (e.g., 12~16 weeks) in vitro, in animal model, and even in human oral cavity, which generally covers the whole formation process of osseointegrated interface. Furthermore, after consumption, it can regain its antibacterial ability by facile rechlorination, highlighting a valuable concept of renewable antibacterial coating in dental implant. These findings indicate an appealing application prospect for prevention and treatment of peri-implant infection.
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Cites
Kinane, D. F., Stathopoulou, P. G., & Papapanou, P. N. (2017) · Nature Reviews Disease Primers · doi:10.1038/nrdp.2017.38 · Cited by 2,724
Implant infections: adhesion, biofilm formation and immune evasion
Arciola, C. R., Campoccia, D., & Montanaro, L. (2018) · Nature Reviews Microbiology · doi:10.1038/s41579-018-0019-y · Cited by 2,241
Osseointegration and its experimental background
Branemark, P.-I. (1983) · The Journal of Prosthetic Dentistry · doi:10.1016/s0022-3913(83)80101-2 · Cited by 2,084
Arciola, C. R., Campoccia, D., Speziale, P., Montanaro, L., & Costerton, J. W. (2012) · Biomaterials · doi:10.1016/j.biomaterials.2012.05.031 · Cited by 1,047
Comparative biology of chronic and aggressive periodontitis vs. peri-implantitis
Heitz-Mayfield, L. J. A., & Lang, N. P. (2010) · Periodontology 2000 · doi:10.1111/j.1600-0757.2010.00348.x · Cited by 538
Management of peri‐implant mucositis and peri‐implantitis
Figuero, E., Graziani, F., Sanz, I., Herrera, D., & Sanz, M. (2014) · Periodontology 2000 · doi:10.1111/prd.12049 · Cited by 407
Chemical Insights into Antibacterial N-Halamines
Dong, A., Wang, Y.-J., Gao, Y., Gao, T., & Gao, G. (2017) · Chemical Reviews · doi:10.1021/acs.chemrev.6b00687 · Cited by 374
Mei, S., Wang, H., Wang, W., Tong, L., Pan, H., Ruan, C., Ma, Q., Liu, M., Yang, H., Zhang, L., et al. (2014) · Biomaterials · doi:10.1016/j.biomaterials.2014.02.005 · Cited by 368
Balancing osteoblast functions and bacterial adhesion on functionalized titanium surfaces
Neoh, K. G., Hu, X., Zheng, D., & Kang, E. T. (2012) · Biomaterials · doi:10.1016/j.biomaterials.2012.01.018 · Cited by 330
Wang, G., Jin, W., Qasim, A. M., Gao, A., Peng, X., Li, W., Feng, H., & Chu, P. K. (2017) · Biomaterials · doi:10.1016/j.biomaterials.2017.01.028 · Cited by 305
Metadata
- Authors
- Wu, S., Xu, J., Zou, L., Luo, S., Yao, R., Zheng, B., Liang, G., Wu, D., & Li, Y.
- Venue
- Nature Communications
- Published
- 2021-06-03
- Volume
- 12
- Issue
- 1
- Pages
- 3303-3303
- ISSN
- 2041-1723 (ISSN-L)
- OpenAlex
- W3164162397
- Cited by
- 280
- References
- 46
- FWCI
- 16.28
- Type
- journal article
- Language
- en
- Open access
- gold
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- Wu, S., Xu, J., Zou, L., Luo, S., Yao, R., Zheng, B., Liang, G., Wu, D., & Li, Y. (2021). Long-lasting renewable antibacterial porous polymeric coatings enable titanium biomaterials to prevent and treat peri-implant infection. Nature Communications. https://doi.org/10.1038/s41467-021-23069-0
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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