Structure of the mature Rous sarcoma virus lattice reveals a role for IP6 in the formation of the capsid hexamer

Obr, Martin; Ricana, Clifton L.; Nikulin, Nadia; Feathers, Jon-Philip R.; Klanschnig, Marco; Thader, Andreas; Johnson, Marc C.; Vogt, Volker M.; Schur, Florian K. M.; Dick, Robert A.

doi:10.1038/s41467-021-23506-0

Structure of the mature Rous sarcoma virus lattice reveals a role for IP6 in the formation of the capsid hexamer

Inositol hexakisphosphate (IP6) is an assembly cofactor for HIV-1. We report here that IP6 is also used for assembly of Rous sarcoma virus (RSV), a retrovirus from a different genus. IP6 is ~100-fold more potent at promoting RSV mature capsid protein (CA) assembly than observed for HIV-1 and remo…