Molecular characterization of colorectal cancer related peritoneal metastatic disease
Open accessAbstract
A significant proportion of colorectal cancer (CRC) patients develop peritoneal metastases (PM) in the course of their disease. PMs are associated with a poor quality of life, significant morbidity and dismal disease outcome. To improve care for this patient group, a better understanding of the molecular characteristics of CRC-PM is required. Here we present a comprehensive molecular characterization of a cohort of 52 patients. This reveals that CRC-PM represent a distinct CRC molecular subtype, CMS4, but can be further divided in three separate categories, each presenting with unique features. We uncover that the CMS4-associated structural protein Moesin plays a key role in peritoneal dissemination. Finally, we define specific evolutionary features of CRC-PM which indicate that polyclonal metastatic seeding underlies these lesions. Together our results suggest that CRC-PM should be perceived as a distinct disease entity.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Trial data are mostly including patients with CRC liver metastasis, excluding or at least under-representing especially peritoneal metastasis as a major unmet research need.
“Further, trial data are mostly including patients with CRC liver metastasis, excluding or at least under-representing especially peritoneal metastasis as a major unmet research need.17”
From Current and emerging concepts for systemic treatment of metastatic colorectal cancer (2025) · cites this paper as [17]
CMS4 is present in the vast majority of peritoneal metastases.
“was shown to be present in the vast majority of peritoneal metastases (24).”
From Clinical Challenges of Consensus Molecular Subtype CMS4 Colon Cancer in the Era of Precision Medicine (2024) · cites this paper as [24]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Sung, H., Ferlay, J., Siegel, R. L., Laversanne, M., Soerjomataram, I., Jemal, A., & Bray, F. (2021) · CA: A Cancer Journal for Clinicians · doi:10.3322/caac.21660 · Cited by 108,699 · see citing works
Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2
Love, M. I., Huber, W., & Anders, S. (2014) · Genome Biology · doi:10.1186/s13059-014-0550-8 · Cited by 95,106 · see citing works
STAR: ultrafast universal RNA-seq aligner
Dobin, A., Davis, C. A., Schlesinger, F., Drenkow, J., Zaleski, C., Jha, S., Batut, P., Chaisson, M., & Gingeras, T. R. (2013) · Bioinformatics · doi:10.1093/bioinformatics/bts635 · Cited by 51,709 · see citing works
RSEM: accurate transcript quantification from RNA-Seq data with or without a reference genome
Li, B., & Dewey, C. N. (2011) · BMC Bioinformatics · doi:10.1186/1471-2105-12-323 · Cited by 22,179 · see citing works
Complex heatmaps reveal patterns and correlations in multidimensional genomic data
Gu, Z., Eils, R., & Schlesner, M. (2016) · Bioinformatics · doi:10.1093/bioinformatics/btw313 · Cited by 10,122 · see citing works
Comprehensive molecular characterization of human colon and rectal cancer
The Cancer Genome Atlas Network (2012) · Nature · doi:10.1038/nature11252 · Cited by 8,499 · see citing works
ConsensusClusterPlus: a class discovery tool with confidence assessments and item tracking
Wilkerson, M. D., & Hayes, D. N. (2010) · Bioinformatics · doi:10.1093/bioinformatics/btq170 · Cited by 5,645 · see citing works
The consensus molecular subtypes of colorectal cancer
Guinney, J., Dienstmann, R., Wang, X., de Reyniès, A., Schlicker, A., Soneson, C., Marisa, L., Roepman, P., Nyamundanda, G., Angelino, P., et al. (2015) · Nature Medicine · doi:10.1038/nm.3967 · Cited by 5,170 · see citing works
Self-citationDifferential analyses for RNA-seq: transcript-level estimates improve gene-level inferences
Soneson, C., Love, M. I., & Robinson, M. D. (2015) · F1000Research · doi:10.12688/f1000research.7563.1 · Cited by 3,929 · see citing works
A Landscape of Pharmacogenomic Interactions in Cancer
Iorio, F., Knijnenburg, T. A., Vis, D. J., Bignell, G. R., Menden, M. P., Schubert, M., Aben, N., Gonçalves, E., Barthorpe, S., Lightfoot, H., et al. (2016) · Cell · doi:10.1016/j.cell.2016.06.017 · Cited by 2,090 · see citing works
Clinical research methodologies in diagnosis and staging of patients with peritoneal carcinomatosis
Jacquet, P., & Sugarbaker, P. H. (1996) · Cancer treatment and research · doi:10.1007/978-1-4613-1247-5_23 · Cited by 1,716 · see citing works
Elias, D. M., Lefèvre, J. H., Chevalier, J., Brouquet, A., Marchal, F., Classe, J., Ferron, G., Guilloit, J., Méeus, P., Goèré, D., et al. (2008) · Journal of Clinical Oncology · doi:10.1200/jco.2008.19.7160 · Cited by 877 · see citing works
Clinical Sequencing Defines the Genomic Landscape of Metastatic Colorectal Cancer
Yaeger, R., Chatila, W. K., Lipsyc, M. D., Hechtman, J. F., Cercek, A., Sanchez-Vega, F., Jayakumaran, G., Middha, S., Zehir, A., Donoghue, M. T. A., et al. (2018) · Cancer Cell · doi:10.1016/j.ccell.2017.12.004 · Cited by 858 · see citing works
Peritoneal carcinomatosis from colorectal cancer
Jayne, D. G., Fook, S., Loi, C. T., & Seow‐Choen, F. (2002) · British journal of surgery · doi:10.1046/j.1365-2168.2002.02274.x · Cited by 832 · see citing works
Tran, B., Kopetz, S., Tie, J., Gibbs, P., Jiang, Z., Lieu, C. H., Agarwal, A., Maru, D. M., Sieber, O. M., & Desai, J. (2011) · Cancer · doi:10.1002/cncr.26086 · Cited by 798 · see citing works
Tsukita, S., Oishi, K., Sato, N., Sagara, J., Kawai, A., & Tsukita, S. (1994) · The Journal of Cell Biology · doi:10.1083/jcb.126.2.391 · Cited by 779 · see citing works
Franko, J., Shi, Q., Meyers, J. P., Maughan, T., Adams, R., Seymour, M., Saltz, L. B., Punt, C. J. A., Koopman, M., Tournigand, C., et al. (2016) · The Lancet Oncology · doi:10.1016/s1470-2045(16)30500-9 · Cited by 688 · see citing works
Self-citationThe Human and Mouse Enteric Nervous System at Single-Cell Resolution
Drokhlyansky, E., Smillie, C. S., Wittenberghe, N. V., Ericsson, M., Griffin, G. K., Eraslan, G., Dionne, D. A., Cuoco, M. S., Goder-Reiser, M. N., Sharova, T. Y., et al. (2020) · Cell · doi:10.1016/j.cell.2020.08.003 · Cited by 585 · see citing works
Incidence, prevalence and risk factors for peritoneal carcinomatosis from colorectal cancer
Segelman, J., Granath, F. N., Holm, T., et al. (2012) · British journal of surgery · doi:10.1002/bjs.8679 · Cited by 510 · see citing works
Peritoneal Carcinomatosis of Colorectal Origin
Koppe, M. J., Boerman, O. C., Oyen, W. J. G., et al. (2006) · Annals of Surgery · doi:10.1097/01.sla.0000197702.46394.16 · Cited by 509 · see citing works
Metastatic pattern in colorectal cancer is strongly influenced by histological subtype
Hugen, N., van de Velde, C. J. �., de Wilt, J. H. W., & Nagtegaal, I. D. (2014) · Annals of Oncology · doi:10.1093/annonc/mdt591 · Cited by 504 · see citing works
Scheinin, I., Sie, D., Bengtsson, H. L., van de Wiel, M. A., Olshen, A. B., van Thuijl, H. F., Essen, H. F. H. V., Eijk, P. P., Rustenburg, F., Meijer, G. A., et al. (2014) · Genome Research · doi:10.1101/gr.175141.114 · Cited by 491 · see citing works
Self-citationReproducible RNA-seq analysis using recount2
Collado‐Torres, L., Nellore, A., Kammers, K., Ellis, S., Taub, M. A., Hansen, K. D., Jaffe, A. E., Langmead, B., & Leek, J. T. (2017) · Nature Biotechnology · doi:10.1038/nbt.3838 · Cited by 439 · see citing works
BRAF mutation is a powerful prognostic factor in advanced and recurrent colorectal cancer
Yokota, T., Ura, T., Shibata, N., Takahari, D., Shitara, K., Nomura, M., Kondo, C., Mizota, A., Utsunomiya, S., Muro, K., et al. (2011) · British Journal of Cancer · doi:10.1038/bjc.2011.19 · Cited by 399 · see citing works
Koh, J., Yan, T. D., Glenn, D. W., et al. (2008) · Annals of Surgical Oncology · doi:10.1245/s10434-008-0234-2 · Cited by 369 · see citing works
Lemmens, V. E. P. P., Klaver, Y. L. B., Verwaal, V. J., et al. (2010) · International Journal of Cancer · doi:10.1002/ijc.25596 · Cited by 355 · see citing works
Takeuchi, K., Sato, N., Kasahara, H., Funayama, N., Nagafuchi, A., Yonemura, S., Tsukita, S., & Tsukita, S. (1994) · The Journal of Cell Biology · doi:10.1083/jcb.125.6.1371 · Cited by 348 · see citing works
Sato, N., Funayama, N., Nagafuchi, A., et al. (1992) · Journal of Cell Science · doi:10.1242/jcs.103.1.131 · Cited by 339 · see citing works
Melo, F. D. S. E., Çolak, S., Buikhuisen, J. Y., Köster, J., Cameron, K., de Jong, J. H., Tuynman, J. B., Prasetyanti, P. R., Fessler, E., van den Bergh, S., et al. (2011) · Cell stem cell · doi:10.1016/j.stem.2011.10.008 · Cited by 333 · see citing works
Self-citationImmunological Functions of the Omentum
Meza‐Perez, S., & Randall, T. D. (2017) · Trends in Immunology · doi:10.1016/j.it.2017.03.002 · Cited by 327 · see citing works
Single-cell multiomics sequencing and analyses of human colorectal cancer
Bian, S., Hou, Y., Zhou, X., Li, X.-L., Yong, J., Wang, Y., Wang, W.-D., Yan, J., Hu, B.-Q., Guo, H.-S., et al. (2018) · Science · doi:10.1126/science.aao3791 · Cited by 326 · see citing works
ERM proteins in cancer progression
Clucas, J., & Valderrama, F. (2014) · Journal of Cell Science · doi:10.1242/jcs.133108 · Cited by 261 · see citing works
Deep learning–based cell composition analysis from tissue expression profiles
Menden, K., Marouf, M., Oller, S., Dalmia, A., Magruder, D. S., Kloiber, K., Heutink, P., & Bonn, S. (2020) · Science Advances · doi:10.1126/sciadv.aba2619 · Cited by 258 · see citing works
Pitroda, S. P., Khodarev, N. N., Huang, L., Uppal, A., Wightman, S. C., Ganai, S., Joseph, N. E., Pitt, J. J., Brown, M., Forde, M., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-04278-6 · Cited by 253 · see citing works
Lenz, H.-J., Ou, F.-S., Venook, A. P., Hochster, H. S., Niedzwiecki, D., Goldberg, R. M., Mayer, R. J., Bertagnolli, M. M., Blanke, C. D., Zemla, T., et al. (2019) · Journal of Clinical Oncology · doi:10.1200/jco.18.02258 · Cited by 246 · see citing works
Ongoing chromosomal instability and karyotype evolution in human colorectal cancer organoids
Bolhaqueiro, A. C. F., Ponsioen, B., Bakker, B., Klaasen, S. J., Küçükköse, E., van Jaarsveld, R. H., Vivié, J., Verlaan-Klink, I., Hami, N., Spierings, D. C. J., et al. (2019) · Nature Genetics · doi:10.1038/s41588-019-0399-6 · Cited by 240 · see citing works
Self-citationChe, L., Liu, J., Huo, J.-P., Luo, R., Xu, R.-M., He, C., Li, Y.-Q., Zhou, A., Huang, P., Chen, Y., et al. (2021) · Cell Discovery · doi:10.1038/s41421-021-00312-y · Cited by 232 · see citing works
Stintzing, S., Wirapati, P., Lenz, H., Neureiter, D., von Weikersthal, L. F., Decker, T. W., Kiani, A., Kaiser, F., Al‐Batran, S., Heintges, T., et al. (2019) · Annals of Oncology · doi:10.1093/annonc/mdz387 · Cited by 196 · see citing works
Metachronous peritoneal carcinomatosis after curative treatment of colorectal cancer
van Gestel, Y. R. B. M., Thomassen, I., Lemmens, V. E. P. P., et al. (2013) · European Journal of Surgical Oncology · doi:10.1016/j.ejso.2013.10.001 · Cited by 180 · see citing works
Song, N., Pogue–Geile, K. L., Gavin, P. G., Yothers, G., Kim, S. R., Johnson, N. L., Lipchik, C., Allegra, C. J., Petrelli, N. J., O’Connell, M. J., et al. (2016) · JAMA Oncology · doi:10.1001/jamaoncol.2016.2314 · Cited by 172 · see citing works
Schirripa, M., Bergamo, F., Cremolini, C., Casagrande, M., Lonardi, S., Aprile, G., Yang, D., Marmorino, F., Pasquini, G., Sensi, E., et al. (2015) · British Journal of Cancer · doi:10.1038/bjc.2015.142 · Cited by 171 · see citing works
ERM proteins in epithelial cell organization and functions
Fiévet, B., Louvard, D., & Arpin, M. (2006) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2006.06.013 · Cited by 159 · see citing works
Thomassen, I., van Gestel, Y. R. B. M., Lemmens, V. E. P. P., & de Hingh, I. H. J. T. (2013) · Diseases of the Colon & Rectum · doi:10.1097/dcr.0b013e3182a62d9d · Cited by 144 · see citing works
Mooi, J. K., Wirapati, P., Asher, R., Lee, C. K., Savas, P. S., Price, T. J., Townsend, A. R., Hardingham, J. E., Buchanan, D. D., Williams, D., et al. (2018) · Annals of Oncology · doi:10.1093/annonc/mdy410 · Cited by 144 · see citing works
Genome‐wide identification of miR‐200 targets reveals a regulatory network controlling cell invasion
Bracken, C. P., Li, X., Wright, J. A., Lawrence, D., Pillman, K. A., Salmanidis, M., Anderson, M. A., Dredge, B. K., Gregory, P. A., Tsykin, A., et al. (2014) · The EMBO Journal · doi:10.15252/embj.201488641 · Cited by 134 · see citing works
MiR-200 can repress breast cancer metastasis through ZEB1-independent but moesin-dependent pathways
Li, X., Roslan, S., Johnstone, C. N., Wright, J. A., Bracken, C. P., Anderson, M. A., Bert, A. G., Selth, L. A., Anderson, R. L., Goodall, G. J., et al. (2013) · Oncogene · doi:10.1038/onc.2013.370 · Cited by 125 · see citing works
Lymph node metastases develop through a wider evolutionary bottleneck than distant metastases
Reiter, J. G., Hung, W., Lee, I., Nagpal, S. V., Giunta, P., Degner, S., Liu, G., Wassenaar, E. C. E., Jeck, W. R., Taylor, M. S., et al. (2020) · Nature Genetics · doi:10.1038/s41588-020-0633-2 · Cited by 122 · see citing works
Self-citationTumor Heterogeneity Predicts Metastatic Potential in Colorectal Cancer
Joung, J., Oh, B. Y., Hong, H. K., Alkhalidi, H., Al-Alem, F., Lee, H., Bae, J. S., Kim, J.-H., Cha, H., Alotaibi, M., et al. (2017) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-17-0306 · Cited by 108 · see citing works
A Systematic Analysis of Oncogenic Gene Fusions in Primary Colon Cancer
Kloosterman, W. P., van den Braak, R. R. J. C., Pieterse, M., van Roosmalen, M. J., Sieuwerts, A. M., Stangl, C., Brunekreef, R., Lalmahomed, Z. S., Ooft, S., van Galen, A., et al. (2017) · Cancer Research · doi:10.1158/0008-5472.can-16-3563 · Cited by 94 · see citing works
Self-citationZhu, X., Morales, F. C., Agarwal, N. K., et al. (2012) · Cancer Research · doi:10.1158/0008-5472.can-12-1040 · Cited by 89 · see citing works
Ubink, I., van Eden, W. J., Snæbjörnsson, P., Kok, N. F. M., van Kuik, J., van Grevenstein, W. M. U., Laclé, M. M., Sanders, J., Fijneman, R. J. A., Elias, S. G., et al. (2018) · British journal of surgery · doi:10.1002/bjs.10788 · Cited by 80 · see citing works
Self-citationChromosomal copy number heterogeneity predicts survival rates across cancers
van Dijk, E., van den Bosch, T., Lenos, K., Makrini, K. E., Nijman, L. E., Essen, H. F. H. V., Lansu, N. R., Boekhout, M., Hageman, J. H., Fitzgerald, R. C., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-23384-6 · Cited by 76 · see citing works
Self-citationZhong, X., Zheng, L., Shen, J., Zhang, D., Xiong, M., Zhang, Y., He, X., Tanyi, J. L., Yang, F., Montone, K. T., et al. (2016) · Molecular and Cellular Biology · doi:10.1128/mcb.00079-16 · Cited by 72 · see citing works
Understanding molecular mechanisms in peritoneal dissemination of colorectal cancer
de Cuba, E. M. V., Kwakman, R., van Egmond, M., Bosch, L. J. W., Bonjer, H. J., Meijer, G. A., & Velde, E. A. T. (2012) · Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin · doi:10.1007/s00428-012-1287-y · Cited by 66 · see citing works
Fessler, E., Jansen, M., Melo, F. D. S. E., Zhao, L., Prasetyanti, P. R., Rodermond, H. M., Kandimalla, R., Linnekamp, J. F., Franitza, M., van Hooff, S. R., et al. (2016) · Oncogene · doi:10.1038/onc.2016.134 · Cited by 54 · see citing works
Self-citationLevin-Sparenberg, E., Bylsma, L. C., Lowe, K. A., Sangaré, L. R., Fryzek, J. P., & Alexander, D. D. (2020) · Gastroenterology Research · doi:10.14740/gr1167 · Cited by 53 · see citing works
Risk factors for appendiceal and colorectal peritoneal metastases
Enblad, M., Graf, W., & Birgisson, H. (2018) · European Journal of Surgical Oncology · doi:10.1016/j.ejso.2018.02.245 · Cited by 49 · see citing works
Bakkers, C., Lurvink, R. J., Rijken, A., et al. (2021) · Annals of Surgical Oncology · doi:10.1245/s10434-021-10190-z · Cited by 47 · see citing works
A mouse model for peritoneal metastases of colorectal origin recapitulates patient heterogeneity
Bastiaenen, V. P., Klaver, C. E. L., van der Heijden, M., Nijman, L. E., Lecca, M. C., Tanis, P. J., Lenos, K., & Vermeulen, L. (2020) · Laboratory Investigation · doi:10.1038/s41374-020-0448-x · Cited by 43 · see citing works
Self-citationKhan, M., Loree, J. M., Advani, S., Ning, J., Li, W., Pereira, A. A. L., Lam, M. S., Raghav, K. P. S., Morris, V. K., Broaddus, R. R., et al. (2018) · Clinical Colorectal Cancer · doi:10.1016/j.clcc.2018.07.005 · Cited by 40 · see citing works
Complex Behavior of ALDH1A1 and IGFBP1 in Liver Metastasis from a Colorectal Cancer
Kim, J. C., Ha, Y. J., Tak, K. H., Roh, S. A., Kim, C. W., Kim, T. W., Kim, S., Kim, S., Cho, D., & Kim, S. (2016) · PLoS ONE · doi:10.1371/journal.pone.0155160 · Cited by 32 · see citing works
KRAS Status in Patients With Colorectal Cancer Peritoneal Carcinomatosis and Its Impact on Outcome
Gillern, S. M., Chua, T. C., Stojadinovic, A., & Esquivel, J. (2010) · American Journal of Clinical Oncology · doi:10.1097/coc.0b013e3181b4b160 · Cited by 26 · see citing works
Sluiter, N. R., Rovers, K. P. B., Salhi, Y., et al. (2018) · Annals of Surgical Oncology · doi:10.1245/s10434-018-6539-x · Cited by 26 · see citing works
Self-citationMetastatic Profile of Colorectal Cancer: Interplay Between Primary Tumor Location and KRAS Status
Yong, Z. Z., Ching, G. T. H., & Ching, M. T. C. (2019) · Journal of Surgical Research · doi:10.1016/j.jss.2018.11.025 · Cited by 20 · see citing works
Hallam, S., Stockton, J., Bryer, C., Whalley, C., Pestinger, V., Youssef, H., & Beggs, A. D. (2020) · Scientific Reports · doi:10.1038/s41598-020-75844-6 · Cited by 14 · see citing works
Self-citationPreoperative chemotherapy for esophageal carcinoma with intramural metastasis
Hokamura, N., Kato, H., Tachimori, Y., Watanabe, H., Yamaguchi, H., & Nakanishi, Y. (2000) · Journal of Surgical Oncology · doi:10.1002/1096-9098(200010)75:2 · Cited by 13 · see citing works
Sharma, N., Saifo, M., Tamaskar, I., et al. (2010) · PubMed · doi:10.3978/j.issn.2078-6891.2010.022 · Cited by 12 · see citing works
Garland‐Kledzik, M., Uppal, A., Naeini, Y. B., et al. (2020) · Journal of Gastrointestinal Surgery · doi:10.1007/s11605-020-04886-y · Cited by 9 · see citing works
Flagged first, then by citations
Research works printed but not linked: 1
- [59]Lenos, K. J. et al. Molecular characterization of colorectal cancer related peritoneal metastatic disease. GitHub, 10.5281/zenodo.6779129 (2022). PMC9352687 35927254 · DOI
Cited by
Sorted by citations
Mouillet-Richard, S., Cazelles, A., Sroussi, M., Gallois, C., Taieb, J., & Laurent-Puig, P. (2024) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-23-3964 · Cited by 43 · see citing works
Current and emerging concepts for systemic treatment of metastatic colorectal cancer
Steup, C., Kennel, K. B., Neurath, M. F., Fichtner-Feigl, S., & Greten, F. R. (2025) · Gut · doi:10.1136/gutjnl-2025-335412 · Cited by 39 · see citing works
- Authors
- Lenos, K. J., Bach, S., Ferreira Moreno, L., ten Hoorn, S., Sluiter, N. R., Bootsma, S., Vieira Braga, F. A., Nijman, L. E., van den Bosch, T., Miedema, D. M., van Dijk, E., Ylstra, B., Kulicke, R., Davis, F. P., Stransky, N., Smolen, G. A., Coebergh van den Braak, R. R. J., IJzermans, J. N. M., Martens, J. W. M., Hallam, S., Beggs, A. D., Kops, G. J. P. L., Lansu, N., Bastiaenen, V. P., Klaver, C. E. L., Lecca, M. C., El Makrini, K., Elbers, C. C., Dings, M. P. G., van Noesel, C. J. M., Kranenburg, O., Medema, J. P., Koster, J., Koens, L., Punt, C. J. A., Tanis, P. J., de Hingh, I. H., Bijlsma, M. F., Tuynman, J. B., & Vermeulen, L.
- Affiliations
- Amsterdam UMC Location University of Amsterdam (NL)
- Cancer Center Amsterdam (NL)
- Celsius Therapeutics (United States) (US)
- Erasmus MC (NL)
- University of Birmingham (GB)
- University Medical Center Utrecht (NL)
- Utrecht University (NL)
- Corresponding author
- Lenos, Kristiaan J.
- Vermeulen, Louis
- ORCID
- Lenos, Kristiaan J.
- Bach, Sander
- Sluiter, Nina R.
- Bootsma, Sanne
- Nijman, Lisanne E.
- van den Bosch, Tom
- van Dijk, Erik
- Ylstra, Bauke
- Kulicke, Ruth
- Davis, Fred P.
- Stransky, Nicolas
- Smolen, Gromoslaw A.
- Coebergh van den Braak, Robert R. J.
- IJzermans, Jan N. M.
- Martens, John W. M.
- Hallam, Sally
- Beggs, Andrew D.
- Kops, Geert J. P. L.
- Bastiaenen, Vivian P.
- Klaver, Charlotte E. L.
- Elbers, Clara C.
- Dings, Mark P. G.
- Kranenburg, Onno
- Medema, Jan Paul
- Koster, Jan
- Koens, Lianne
- Punt, Cornelis J. A.
- Tanis, Pieter J.
- Bijlsma, Maarten F.
- Tuynman, Jurriaan B.
- Vermeulen, Louis
- Venue
- Nature Communications
- Published
- 2022-08-04
- Volume
- 13
- Issue
- 1
- Pages
- 4443-4443
- ISSN
- 2041-1723 (ISSN-L)
- PMC
- PMC9352687
- OpenAlex
- W4289836879
- Cited by
- 125
- References
- 68
- Citations by year
- 2026: 24 · 2025: 36 · 2024: 39 · 2023: 21 · 2022: 3
- FWCI
- 25.79
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Nature Communications (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Research Publications (Maastricht University) (publishedVersion, cc-by)
- University of Birmingham Research Portal (University of Birmingham) (publishedVersion, cc-by)
- EUR Research Repository (Erasmus University Rotterdam) (publishedVersion, cc-by)
- KNAW Research Portal (The Royal Netherlands Academy of Arts and Sciences) (publishedVersion, other-oa)
- Data Archiving and Networked Services (DANS) (submittedVersion, other-oa)
- EUR Research Repository (Erasmus University Rotterdam) (submittedVersion, cc-by)
- RePEc: Research Papers in Economics (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Utrecht University Repository (Utrecht University) (submittedVersion, other-oa)
- Pure Amsterdam UMC (submittedVersion, cc-by)
- Amsterdam UMC (VU Amsterdam) - Institutional Repository (submittedVersion, other-oa)
- Research Publications (Maastricht University) (submittedVersion, other-oa)
- Funders
- KWF Kankerbestrijding (13435, 10529)
- ZonMw (Vidi 016.156.308)
- This work is supported by the Academic Medical Center (Amsterdam), The New York Stem Cell Foundation, L.V. is a New York Stem Cell Foundation – Robertson Investigator.
- Topics
- Health Sciences › Medicine › Surgery › Intraperitoneal and Appendiceal Malignancies
- Health Sciences › Medicine › Oncology › Colorectal Cancer Treatments and Studies
- Health Sciences › Medicine › Pathology and Forensic Medicine › Genetic factors in colorectal cancer
- Keywords
- colorectal cancer, peritoneal carcinomatosis, molecular subtypes, CMS4, moesin, tumor evolution, molecular characterization
- MeSH terms
- Humans, Peritoneal Neoplasms, Peritoneum, Quality of Life, Colorectal Neoplasms, Neoplasms, Second Primary
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
