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Cited by 304

The DOI matches its Crossref record; 57 of the 57 references it cites were found in a registry or an index.

Genomic analysis of sewage from 101 countries reveals global landscape of antimicrobial resistance

Open access
Munk, Patrick, Brinch, Christian, Møller, Frederik Duus, Petersen, Thomas N., Hendriksen, Rene S., Seyfarth, Anne Mette, Kjeldgaard, Jette S., Svendsen, Christina Aaby, van Bunnik, Bram, Berglund, Fanny, Global Sewage Surveillance Consortium, Bego, Artan, Power, Pablo, Rees, Catherine, Lambrinidis, Dionisia, Neilson, Elizabeth Heather Jakobsen, Gibb, Karen, Coventry, Kris, Collignon, Peter, Cassar, Susan, Allerberger, Franz, Begum, Anowara, Hossain, Zenat Zebin, Worrell, Carlon, Vandenberg, Olivier, Pieters, Ilse, Victorien, Dougnon Tamègnon, Gutierrez, Angela Daniela Salazar, Soria, Freddy, Grujić, Vesna Rudić, Mazalica, Nataša, Rahube, Teddie O., Tagliati, Carlos Alberto, Rodrigues, Dalia, Oliveira, Guilherme, de Souza, Larissa Camila Ribeiro, Ivanov, Ivan, Juste, Bonkoungou Isidore, Oumar, Traoré, Sopheak, Thet, Vuthy, Yith, Ngandjio, Antoinette, Nzouankeu, Ariane, Olivier, Ziem A. Abah Jacques, Yost, Christopher K., Kumar, Pratik, Brar, Satinder Kaur, Tabo, Djim-Adjim, Adell, Aiko D., Paredes-Osses, Esteban, Martinez, Maria Cristina, Cuadros-Orellana, Sara, Ke, Changwen, Zheng, Huanying, Baisheng, Li, Lau, Lok Ting, Chung, Teresa, Jiao, Xiaoyang, Yu, Yongjie, JiaYong, Zhao, Morales, Johan F. Bernal, Valencia, Maria Fernanda, Donado-Godoy, Pilar, Coulibaly, Kalpy Julien, Hrenovic, Jasna, Jergović, Matijana, Karpíšková, Renáta, Deogratias, Zozo Nyarukweba, Elsborg, Bodil, Hansen, Lisbeth Truelstrup, Jensen, Pernille Erland, Abouelnaga, Mohamed, Salem, Mohamed Fathy, Koolmeister, Marliin, Legesse, Mengistu, Eguale, Tadesse, Heikinheimo, Annamari, Le Guyader, Soizick, Schaeffer, Julien, Villacis, Jose Eduardo, Sanneh, Bakary, Malania, Lile, Nitsche, Andreas, Brinkmann, Annika, Schubert, Sara, Hesse, Sina, Berendonk, Thomas U., Saba, Courage Kosi Setsoafia, Mohammed, Jibril, Feglo, Patrick Kwame, Banu, Regina Ama, Kotzamanidis, Charalampos, Lytras, Efthymios, Lickes, Sergio A., Kocsis, Bela, Solymosi, Norbert, Thorsteinsdottir, Thorunn R., Hatha, Abdulla Mohamed, Ballal, Mamatha, Bangera, Sohan Rodney, Fani, Fereshteh, Alebouyeh, Masoud, Morris, Dearbhaile, O’Connor, Louise, Cormican, Martin, Moran-Gilad, Jacob, Battisti, Antonio, Diaconu, Elena Lavinia, Corno, Gianluca, Di Cesare, Andrea, Alba, Patricia, Hisatsune, Junzo, Yu, Liansheng, Kuroda, Makoto, Sugai, Motoyuki, Kayama, Shizuo, Shakenova, Zeinegul, Kiiyukia, Ciira, Ng’eno, Eric, Raka, Lul, Jamil, Kazi, Fakhraldeen, Saja Adel, Alaati, Tareq, Bērziņš, Aivars, Avsejenko, Jeļena, Kokina, Kristina, Streikisa, Madara, Bartkevics, Vadims, Matar, Ghassan M., Daoud, Ziad, Pereckienė, Asta, Butrimaite-Ambrozeviciene, Ceslova, Penny, Christian, Bastaraud, Alexandra, Rasolofoarison, Tiavina, Collard, Jean-Marc, Samison, Luc Hervé, Andrianarivelo, Mala Rakoto, Banda, Daniel Lawadi, Amin, Arshana, Rajandas, Heraa, Parimannan, Sivachandran, Spiteri, David, Haber, Malcolm Vella, Santchurn, Sunita J., Vujacic, Aleksandar, Djurovic, Dijana, Bouchrif, Brahim, Karraouan, Bouchra, Vubil, Delfino Carlos, Pal, Pushkar, Schmitt, Heike, van Passel, Mark, Jeunen, Gert-Jan, Gemmell, Neil, Chambers, Stephen T., Mendoza, Fania Perez, Huete-Pιrez, Jorge, Vilchez, Samuel, Ahmed, Akeem Olayiwola, Adisa, Ibrahim Raufu, Odetokun, Ismail Ayoade, Fashae, Kayode, Sørgaard, Anne-Marie, Wester, Astrid Louise, Ryrfors, Pia, Holmstad, Rune, Mohsin, Mashkoor, Hasan, Rumina, Shakoor, Sadia, Gustafson, Natalie Weiler, Schill, Claudia Huber, Rojas, Maria Luz Zamudio, Velasquez, Jorge Echevarria, Magtibay, Bonifacio B., Catangcatang, Kris, Sibulo, Ruby, Yauce, Felipe Campos, Wasyl, Dariusz, Manaia, Celia, Rocha, Jaqueline, Martins, Jose, Álvaro, Pedro, Di Yoong Wen, Doris, Shin, Hanseob, Hur, Hor-Gil, Yoon, Sukhwan, Bosevska, Golubinka, Kochubovski, Mihail, Cojocaru, Radu, Burduniuc, Olga, Hong, Pei-Ying, Perry, Meghan Rose, Gassama, Amy, Radosavljevic, Vladimir, Tay, Moon Y. F., Zuniga-Montanez, Rogelio, Wuertz, Stefan, Gavačová, Dagmar, Pastuchová, Katarína, Truska, Peter, Trkov, Marija, Keddy, Karen, Esterhuyse, Kerneels, Song, Min Joon, Quintela-Baluja, Marcos, Lopez, Mariano Gomez, Cerdà-Cuéllar, Marta, Perera, R. R. D. P., Bandara, N. K. B. K. R. G. W., Premasiri, H. I., Pathirage, Sujatha, Charlemagne, Kareem, Rutgersson, Carolin, Norrgren, Leif, Örn, Stefan, Boss, Renate, Van der Heijden, Tanja, Hong, Yu-Ping, Kumburu, Happiness Houka, Mdegela, Robinson Hammerthon, Hounmanou, Yaovi Mahuton Gildas, Chonsin, Kaknokrat, Suthienkul, Orasa, Thamlikitkul, Visanu, de Roda Husman, Ana Maria, Bidjada, Bawimodom, Njanpop-Lafourcade, Berthe-Marie, Nikiema-Pessinaba, Somtinda Christelle, Levent, Belkis, Kurekci, Cemil, Ejobi, Francis, Kalule, John Bosco, Thomsen, Jens, Obaidi, Ouidiane, Jassim, Laila Mohamed, Moore, Andrew, Leonard, Anne, Graham, David W., Bunce, Joshua T., Zhang, Lihong, Gaze, William H., Lefor, Brett, Capone, Drew, Sozzi, Emanuele, Brown, Joe, Meschke, John Scott, Sobsey, Mark D., Davis, Michael, Beck, Nicola Koren, Sukapanpatharam, Pardi, Truong, Phuong, Lilienthal, Ronald, Kang, Sanghoon, Wittum, Thomas E., Rigamonti, Natalia, Baklayan, Patricia, Van, Chinh Dang, Tran, Doan Minh Nguyen, Do Phuc, Nguyen, Kwenda, Geoffrey, Larsson, D. G. Joakim, Koopmans, Marion, Woolhouse, Mark, Aarestrup, Frank M.·2022·Nature Communications
DOI 10.1038/s41467-022-34312-7
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Abstract

Antimicrobial resistance (AMR) is a major threat to global health. Understanding the emergence, evolution, and transmission of individual antibiotic resistance genes (ARGs) is essential to develop sustainable strategies combatting this threat. Here, we use metagenomic sequencing to analyse ARGs in 757 sewage samples from 243 cities in 101 countries, collected from 2016 to 2019. We find regional patterns in resistomes, and these differ between subsets corresponding to drug classes and are partly driven by taxonomic variation. The genetic environments of 49 common ARGs are highly diverse, with most common ARGs carried by multiple distinct genomic contexts globally and sometimes on plasmids. Analysis of flanking sequence revealed ARG-specific patterns of dispersal limitation and global transmission. Our data furthermore suggest certain geographies are more prone to transmission events and should receive additional attention.

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Authors
Munk, P., Brinch, C., Møller, F. D., Petersen, T. N., Hendriksen, R. S., Seyfarth, A. M., Kjeldgaard, J. S., Svendsen, C. A., van Bunnik, B., Berglund, F., Global Sewage Surveillance Consortium, Bego, A., Power, P., Rees, C., Lambrinidis, D., Neilson, E. H. J., Gibb, K., Coventry, K., Collignon, P., Cassar, S., Allerberger, F., Begum, A., Hossain, Z. Z., Worrell, C., Vandenberg, O., Pieters, I., Victorien, D. T., Gutierrez, A. D. S., Soria, F., Grujić, V. R., Mazalica, N., Rahube, T. O., Tagliati, C. A., Rodrigues, D., Oliveira, G., de Souza, L. C. R., Ivanov, I., Juste, B. I., Oumar, T., Sopheak, T., Vuthy, Y., Ngandjio, A., Nzouankeu, A., Olivier, Z. A. A. J., Yost, C. K., Kumar, P., Brar, S. K., Tabo, D.-A., Adell, A. D., Paredes-Osses, E., Martinez, M. C., Cuadros-Orellana, S., Ke, C., Zheng, H., Baisheng, L., Lau, L. T., Chung, T., Jiao, X., Yu, Y., JiaYong, Z., Morales, J. F. B., Valencia, M. F., Donado-Godoy, P., Coulibaly, K. J., Hrenovic, J., Jergović, M., Karpíšková, R., Deogratias, Z. N., Elsborg, B., Hansen, L. T., Jensen, P. E., Abouelnaga, M., Salem, M. F., Koolmeister, M., Legesse, M., Eguale, T., Heikinheimo, A., Le Guyader, S., Schaeffer, J., Villacis, J. E., Sanneh, B., Malania, L., Nitsche, A., Brinkmann, A., Schubert, S., Hesse, S., Berendonk, T. U., Saba, C. K. S., Mohammed, J., Feglo, P. K., Banu, R. A., Kotzamanidis, C., Lytras, E., Lickes, S. A., Kocsis, B., Solymosi, N., Thorsteinsdottir, T. R., Hatha, A. M., Ballal, M., Bangera, S. R., Fani, F., Alebouyeh, M., Morris, D., O’Connor, L., Cormican, M., Moran-Gilad, J., Battisti, A., Diaconu, E. L., Corno, G., Di Cesare, A., Alba, P., Hisatsune, J., Yu, L., Kuroda, M., Sugai, M., Kayama, S., Shakenova, Z., Kiiyukia, C., Ng’eno, E., Raka, L., Jamil, K., Fakhraldeen, S. A., Alaati, T., Bērziņš, A., Avsejenko, J., Kokina, K., Streikisa, M., Bartkevics, V., Matar, G. M., Daoud, Z., Pereckienė, A., Butrimaite-Ambrozeviciene, C., Penny, C., Bastaraud, A., Rasolofoarison, T., Collard, J.-M., Samison, L. H., Andrianarivelo, M. R., Banda, D. L., Amin, A., Rajandas, H., Parimannan, S., Spiteri, D., Haber, M. V., Santchurn, S. J., Vujacic, A., Djurovic, D., Bouchrif, B., Karraouan, B., Vubil, D. C., Pal, P., Schmitt, H., van Passel, M., Jeunen, G.-J., Gemmell, N., Chambers, S. T., Mendoza, F. P., Huete-Pιrez, J., Vilchez, S., Ahmed, A. O., Adisa, I. R., Odetokun, I. A., Fashae, K., Sørgaard, A.-M., Wester, A. L., Ryrfors, P., Holmstad, R., Mohsin, M., Hasan, R., Shakoor, S., Gustafson, N. W., Schill, C. H., Rojas, M. L. Z., Velasquez, J. E., Magtibay, B. B., Catangcatang, K., Sibulo, R., Yauce, F. C., Wasyl, D., Manaia, C., Rocha, J., Martins, J., Álvaro, P., Di Yoong Wen, D., Shin, H., Hur, H.-G., Yoon, S., Bosevska, G., Kochubovski, M., Cojocaru, R., Burduniuc, O., Hong, P.-Y., Perry, M. R., Gassama, A., Radosavljevic, V., Tay, M. Y. F., Zuniga-Montanez, R., Wuertz, S., Gavačová, D., Pastuchová, K., Truska, P., Trkov, M., Keddy, K., Esterhuyse, K., Song, M. J., Quintela-Baluja, M., Lopez, M. G., Cerdà-Cuéllar, M., Perera, R. R. D. P., Bandara, N. K. B. K. R. G. W., Premasiri, H. I., Pathirage, S., Charlemagne, K., Rutgersson, C., Norrgren, L., Örn, S., Boss, R., Van der Heijden, T., Hong, Y.-P., Kumburu, H. H., Mdegela, R. H., Hounmanou, Y. M. G., Chonsin, K., Suthienkul, O., Thamlikitkul, V., de Roda Husman, A. M., Bidjada, B., Njanpop-Lafourcade, B.-M., Nikiema-Pessinaba, S. C., Levent, B., Kurekci, C., Ejobi, F., Kalule, J. B., Thomsen, J., Obaidi, O., Jassim, L. M., Moore, A., Leonard, A., Graham, D. W., Bunce, J. T., Zhang, L., Gaze, W. H., Lefor, B., Capone, D., Sozzi, E., Brown, J., Meschke, J. S., Sobsey, M. D., Davis, M., Beck, N. K., Sukapanpatharam, P., Truong, P., Lilienthal, R., Kang, S., Wittum, T. E., Rigamonti, N., Baklayan, P., Van, C. D., Tran, D. M. N., Do Phuc, N., Kwenda, G., Larsson, D. G. J., Koopmans, M., Woolhouse, M., & Aarestrup, F. M.
Venue
Nature Communications
Publisher
Springer Science and Business Media LLC
Published
2022-12-01
Volume
13
Issue
1
Pages
7251-7251
ISSN
2041-1723 (ISSN-L)
DOI
10.1038/s41467-022-34312-7
OpenAlex
W4310708706
Cited by
304
References
57
FWCI
11.60
Type
journal article
Language
en
Open access
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Munk, P., Brinch, C., Møller, F. D., Petersen, T. N., Hendriksen, R. S., Seyfarth, A. M., Kjeldgaard, J. S., Svendsen, C. A., van Bunnik, B., Berglund, F., Global Sewage Surveillance Consortium, Bego, A., Power, P., Rees, C., Lambrinidis, D., Neilson, E. H. J., Gibb, K., Coventry, K., Collignon, P., . . . Aarestrup, F. M. (2022). Genomic analysis of sewage from 101 countries reveals global landscape of antimicrobial resistance. Nature Communications. https://doi.org/10.1038/s41467-022-34312-7

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