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Cited by 44Bacteriophages and microbial interactionsEvolution and Genetic DynamicsPlant and Fungal Interactions Research

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Highly host-linked viromes in the built environment possess habitat-dependent diversity and functions for potential virus-host coevolution

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Du, Shicong, Tong, Xinzhao, Lai, Alvin C. K., Chan, Chak K., Mason, Christopher E., Lee, Patrick K. H.·2023·Nature Communications
DOI 10.1038/s41467-023-38400-0PMC PMC10169181

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Abstract

Viruses in built environments (BEs) raise public health concerns, yet they are generally less studied than bacteria. To better understand viral dynamics in BEs, this study assesses viromes from 11 habitats across four types of BEs with low to high occupancy. The diversity, composition, metabolic functions, and lifestyles of the viromes are found to be habitat dependent. Caudoviricetes species are ubiquitous on surface habitats in the BEs, and some of them are distinct from those present in other environments. Antimicrobial resistance genes are identified in viruses inhabiting surfaces frequently touched by occupants and in viruses inhabiting occupants’ skin. Diverse CRISPR/Cas immunity systems and anti-CRISPR proteins are found in bacterial hosts and viruses, respectively, consistent with the strongly coupled virus–host links. Evidence of viruses potentially aiding host adaptation in a specific-habitat manner is identified through a unique gene insertion. This work illustrates that virus–host interactions occur frequently in BEs and that viruses are integral members of BE microbiomes.

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Metadata

Authors
Du, S., Tong, X., Lai, A. C. K., Chan, C. K., Mason, C. E., & Lee, P. K. H.
Affiliations
  • City University of Hong Kong (HK)
  • Weill Cornell Medicine (US)
Corresponding author
Lee, Patrick K. H.
ORCID
Venue
Nature Communications
Publisher
Springer Science and Business Media LLC
Published
2023-05-09
Volume
14
Issue
1
Pages
2676-2676
ISSN
2041-1723 (ISSN-L)
DOI
10.1038/s41467-023-38400-0
PMC
PMC10169181
OpenAlex
W4376132774
Cited by
44
References
2
Citations by year
2026: 12 · 2025: 15 · 2024: 16 · 2023: 1
FWCI
7.11
Type
journal article
Language
en
Open access
Licence
Locations
  • Nature Communications (publishedVersion, cc-by)
  • Research Square (acceptedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • CityU Scholars (submittedVersion, cc-by)
  • RePEc: Research Papers in Economics (submittedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • Rare & Special e-Zone (The Hong Kong University of Science and Technology) (submittedVersion)
Funders
  • Impact Fund
  • National Institutes of Health
  • National Institute on Drug Abuse (U01DA053941)
  • National Institute of Allergy and Infectious Diseases (R01AI151059)
Topics
  • Life Sciences › Immunology and Microbiology › Virology › Bacteriophages and microbial interactions
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Evolution and Genetic Dynamics
  • Life Sciences › Immunology and Microbiology › Virology › Plant and Fungal Interactions Research
Keywords
host-virus coevolution, host-virus interaction, Caudoviricetes, antimicrobial resistance genes, CRISPR-Cas, anti-CRISPR proteins, built environment microbiome
MeSH terms
Built Environment, Virome, Alkanesulfonic Acids, Microbiota

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