A genetically tractable non-vertebrate system to study complete camera-type eye regeneration
Open accessPublished version of a preprint
Abstract
ABSTRACT Camera-type eyes are complex sensory organs susceptible to irreversible damage. Their repair is difficult to study due to the paucity of camera-type eye regeneration models. Identifying a genetically tractable organism with the ability to fully regenerate complete camera-type eyes would help overcome this difficulty. Here, we introduce the apple snail Pomacea canaliculata , capable of full regeneration of camera-type eyes even after complete resection. We defined anatomical components of P. canaliculata eyes and genes expressed during crucial steps of their regeneration. By exploiting the unique features of this organism, we successfully established the first stable mutant lines in apple snails. Our studies revealed that, akin to humans, pax6 is indispensable for eye development in apple snails, establishing this as a research organism to unravel the mechanisms of camera-type eye regeneration. This work expands our understanding of complex sensory organ regeneration and offers new ways to explore this process.
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- Authors
- Accorsi, A., Pardo, B., Ross, E., Corbin, T. J., McClain, M., Weaver, K., Delventhal, K., Gattamraju, A., Morrison, J. A., McKinney, M. C., McKinney, S. A., & Sánchez Alvarado, A.
- Affiliations
- Stowers Institute for Medical Research (US)
- University of California, Davis (US)
- Corresponding author
- Accorsi, Alice
- ORCID
- Venue
- Nature Communications
- Published
- 2025-08-06
- Volume
- 16
- Issue
- 1
- Pages
- 6698-6698
- ISSN
- 2041-1723 (ISSN-L)
- PMC
- PMC12328594
- OpenAlex
- W4413025412
- Cited by
- 14
- References
- 5
- Citations by year
- 2026: 6 · 2025: 5 · 2024: 3
- FWCI
- 3.31
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Nature Communications (publishedVersion, cc-by-nc-nd)
- bioRxiv (Cold Spring Harbor Laboratory) (acceptedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Howard Hughes Medical Institute
- Stowers Institute for Medical Research
- Society for Developmental Biology
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Planarian Biology and Electrostimulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Retinal Development and Disorders
- Keywords
- Pomacea canaliculata, apple snail, eye development, Pax6, mutant strain, genetic model organisms, eye anatomy
- MeSH terms
- PAX6 Transcription Factor, Animals, Eye, Regeneration, Snails
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