The DOI matches its Crossref record; 233 of the 233 references it cites were found in a registry or an index.
Practical classification of triple-negative breast cancer: intratumoral heterogeneity, mechanisms of drug resistance, and novel therapies
Open accessAbstract
Triple-negative breast cancer (TNBC) is not a unique disease, encompassing multiple entities with marked histopathological, transcriptomic and genomic heterogeneity. Despite several efforts, transcriptomic and genomic classifications have remained merely theoretic and most of the patients are being treated with chemotherapy. Driver alterations in potentially targetable genes, including PIK3CA and AKT, have been identified across TNBC subtypes, prompting the implementation of biomarker-driven therapeutic approaches. However, biomarker-based treatments as well as immune checkpoint inhibitor-based immunotherapy have provided contrasting and limited results so far. Accordingly, a better characterization of the genomic and immune contexture underpinning TNBC, as well as the translation of the lessons learnt in the metastatic disease to the early setting would improve patients’ outcomes. The application of multi-omics technologies, biocomputational algorithms, assays for minimal residual disease monitoring and novel clinical trial designs are strongly warranted to pave the way toward personalized anticancer treatment for patients with TNBC.
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1 retracted
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Cited by
Bartlett, T. E., Jia, P., Chandna, S., & Roy, S. (2021) · Scientific Reports · doi:10.1038/s41598-021-03161-7 · Cited by 6
Metadata
- Authors
- Marra, A., Trapani, D., Viale, G., Criscitiello, C., & Curigliano, G.
- Venue
- npj Breast Cancer
- Published
- 2020-10-16
- Volume
- 6
- Issue
- 1
- Pages
- 54-54
- ISSN
- 2374-4677 (ISSN-L)
- OpenAlex
- W3093593152
- Cited by
- 317
- References
- 233
- FWCI
- 13.09
- Type
- journal article
- Language
- en
- Open access
- gold
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- Marra, A., Trapani, D., Viale, G., Criscitiello, C., & Curigliano, G. (2020). Practical classification of triple-negative breast cancer: intratumoral heterogeneity, mechanisms of drug resistance, and novel therapies. npj Breast Cancer. https://doi.org/10.1038/s41523-020-00197-2
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
