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Cited by 29Spaceflight effects on biologySpace exploration and regulationSpace Science and Extraterrestrial Life

From the bench to exploration medicine: NASA life sciences translational research for human exploration and habitation missions

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Alwood, Joshua S., Ronca, April E., Mains, Richard C., Shelhamer, Mark J., Smith, Jeffrey D., Goodwin, Thomas J.·2017·npj Microgravity
DOI 10.1038/s41526-016-0002-8PMC PMC5460236
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Abstract

NASA’s Space Biology and Human Research Program entities have recently spearheaded communications both internally and externally to coordinate the agency’s translational research efforts. In this paper, we strongly advocate for translational research at NASA, provide recent examples of NASA sponsored early-stage translational research, and discuss options for a path forward. Our overall objective is to help in stimulating a collaborative research across multiple disciplines and entities that, working together, will more effectively and more rapidly achieve NASA’s goals for human spaceflight.

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  • Candidate antioxidant cocktails have been proposed based on the scientific knowledge of their effects, but their translation to the field, and specifically to astronauts, has not been successful.

    “Even if candidate antioxidant cocktails have been proposed based on the scientific knowledge of their effects, their translation to the field, and specifically to astronauts, has not been successful47,53,54.”

    From Key points for the development of antioxidant cocktails to prevent cellular stress and damage caused by reactive oxygen species (ROS) during manned space missions (2021) · cites this paper as [53]

    The Oxidative stress section (page unavailable) reports oxidative-related issues in astronauts and mitigation of radiation-induced oxidative stress in mice. Searches for antioxidant cocktails and their translation to astronauts found no passage saying that cocktails were proposed or that translation was unsuccessful. (LLM, conf=0.72)

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Authors
Alwood, J. S., Ronca, A. E., Mains, R. C., Shelhamer, M. J., Smith, J. D., & Goodwin, T. J.
Affiliations
  • Ames Research Center (US)
  • National Aeronautics and Space Administration (US)
  • Johnson Space Center (US)
Corresponding author
Alwood, Joshua S.
ORCID
Venue
npj Microgravity
Publisher
Springer Science and Business Media LLC
Published
2017-01-12
Volume
3
Issue
1
Pages
5-5
ISSN
2373-8065 (ISSN-L)
DOI
10.1038/s41526-016-0002-8
PMC
PMC5460236
OpenAlex
W2576410047
Cited by
29
References
54
Citations by year
2026: 1 · 2025: 2 · 2024: 1 · 2023: 4 · 2022: 1 · 2021: 5 · 2020: 3 · 2019: 4 · 2018: 5 · 2017: 2 · 2016: 1
FWCI
2.83
Type
journal article
Language
en
Open access
Licence
Locations
  • npj Microgravity (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
  • National Aeronautics and Space Administration
  • NASA Headquarters
Topics
  • Health Sciences › Medicine › Physiology › Spaceflight effects on biology
  • Physical Sciences › Physics and Astronomy › Astronomy and Astrophysics › Space exploration and regulation
  • Physical Sciences › Physics and Astronomy › Astronomy and Astrophysics › Space Science and Extraterrestrial Life
Keywords
translational research, human spaceflight, space biology, human exploration, research coordination, interdisciplinary collaboration

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