The DOI matches its Crossref record; 53 of the 53 references it cites were found in a registry or an index.
Cardiac recovery via extended cell-free delivery of extracellular vesicles secreted by cardiomyocytes derived from induced pluripotent stem cells
Open accessAbstract
The ability of extracellular vesicles (EVs) to regulate a broad range of cellular processes has recently been exploited for the treatment of diseases. For example, EVs secreted by therapeutic cells injected into infarcted hearts can induce recovery through the delivery of cell-specific microRNAs. However, retention of the EVs and the therapeutic effects are short-lived. Here, we show that an engineered hydrogel patch capable of slowly releasing EVs secreted from cardiomyocytes (CMs) derived from induced pluripotent stem cells reduced arrhythmic burden, promoted ejection-fraction recovery, decreased CM apoptosis 24 h after infarction, and reduced infarct size and cell hypertrophy 4 weeks post-infarction when implanted onto infarcted rat hearts. We also show that EVs are enriched with cardiac-specific microRNAs known to modulate CM-specific processes. The extended delivery of EVs secreted from induced-pluripotent-stem-cell-derived CMs into the heart may help us to treat heart injury and to understand heart recovery. A hydrogel patch for the sustained delivery of extracellular vesicles from cardiomyocytes derived from induced pluripotent stem cells improves tissue regeneration in infarcted rat hearts.
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Cites
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Cited by
Hong, Y. J., Jeong, H., Cho, K. W., Lu, N., & Kim, D. (2019) · Advanced Functional Materials · doi:10.1002/adfm.201808247 · Cited by 559
Brennan, M. Á., Layrolle, P., & Mooney, D. J. (2020) · Advanced Functional Materials · doi:10.1002/adfm.201909125 · Cited by 396
Qiao, L., Hu, S., Liu, S., Zhang, H., Ma, H., Huang, K., Li, Z., Su, T., Vandergriff, A., Tang, J., et al. (2019) · Journal of Clinical Investigation · doi:10.1172/jci123135 · Cited by 303
Bejleri, D., Streeter, B. W., Nachlas, A. L. Y., Brown, M. E., Gaetani, R., Christman, K. L., & Davis, M. E. (2018) · Advanced Healthcare Materials · doi:10.1002/adhm.201800672 · Cited by 255
Mardpour, S., Ghanian, M. H., Sadeghi-abandansari, H., Mardpour, S., Nazari, A., Shekari, F., & Baharvand, H. (2019) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.9b10126 · Cited by 211
Metadata
- Authors
- Liu, B., Lee, B. W., Nakanishi, K., Villasante, A., Williamson, R., Metz, J., Kim, J., Kanai, M., Bi, L., Brown, K., Di Paolo, G., Homma, S., Sims, P. A., Topkara, V. K., & Vunjak-Novakovic, G.
- Venue
- Nature Biomedical Engineering
- Published
- 2018-04-23
- Volume
- 2
- Issue
- 5
- Pages
- 293-303
- ISSN
- 2157-846X (ISSN-L)
- OpenAlex
- W2802715752
- Cited by
- 371
- References
- 53
- FWCI
- 12.09
- Type
- journal article
- Language
- en
- Open access
- green
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- Liu, B., Lee, B. W., Nakanishi, K., Villasante, A., Williamson, R., Metz, J., Kim, J., Kanai, M., Bi, L., Brown, K., Di Paolo, G., Homma, S., Sims, P. A., Topkara, V. K., & Vunjak-Novakovic, G. (2018). Cardiac recovery via extended cell-free delivery of extracellular vesicles secreted by cardiomyocytes derived from induced pluripotent stem cells. Nature Biomedical Engineering. https://doi.org/10.1038/s41551-018-0229-7
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